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| 1 | Enzymatic vitrectomy for diabetic retinopathy and diabetic macular edema显示文摘The aim of this paper is to determine the role of enzymatic vitrectomy performed by intravitreal injection of autologous plasmin enzyme(APE)in the management of diabetic retinopathy and diabetic macular edema(DME).Diabetic patients with proliferative diabetic retinopathy or DME and evident posterior hyaloid adherence to the retinal surface were included.All cases were treated with an initial intravitreal injection of APE and reevaluated one month later,measuring changes in best-corrected visual acuity(BCVA),macular thickness and the status of the posterior hyaloid.A second APE injection was performed in cases with no evident posterior vitreous detachment(PVD)after the initial treatment.Sixty-three eyes were included in the present review.A complete PVD appeared in 38%of cases(24 eyes)after one injection of plasmin and the total increased to 51%(32 eyes)after the second injection,separated at least by one month.The central macular thickness improved in all cases(100%)and BCVA in89%.Finally,in 50%of eyes with proliferative diabetic retinopathy,a high reduction of new vessels regression was observed.Enzymatic vitrectomy could be considered a good therapeutic alternative in diabetic retinopathy and macular edema. | Manuel Diaz-Llopis Patricia Udaondo Jose Maria Millán J Fernando Arevalo | 2013 | World Journal of Diabetes2013，4，6： | 6 |
| 2 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 3 | Analysis and biological properties of amino acid derivates formed by Maillard reaction in foods显示文摘 | José Manuel Silván Jürgen van de Lagemaat Agustín Olano Maria Dolores del Castillo | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，，5： | 2 |
| 4 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 5 | Histology and ultrastructure of the hepatopancreas of the tigerfish, Hydrocynus forskahlii 显示文摘 | GEYER H J MARIA M N SWANEPOEL J H | 1996 | J Morph1996，，： | 1 |
| 6 | Newinsights on glyphosate mode of action in nodularmetabolism:role of shikimate accumulation 显示文摘 | De Maria N Becerril J M Garcia-Plazaola J I | 2006 | Journalof Agricultural and Food Chemistry2006，54，7： | 1 |
| 7 | Age of male circumcision and risk of prevalent HIV infection in rural Uganda 显示文摘 | Kelly R Kiwanuka N Maria J W | 1999 | AIDS1999，13，3： | 1 |
| 8 | New insights on glyphosate mode of action in nodular metabolism: Role of shikimate accumula- tion 显示文摘 | De Maria N Becerril J M Garcla-Plazaola J I | 2006 | Journal of Agricultural and Food Chem- istry2006，54，： | 1 |
| 9 | Size fractionation of non-volatile dissolved organic compounds and metal species in German white wines by combining on-line tangential-flow multistage ultra-filtration, a home-built carbon anal- yser, and inductively coupled plasma mass spectrometry 显示文摘 | Maria M C P BURBA N JAKUBOWSKI J A | 2003 | Anal Bioanal Chem2003，，376： | 1 |
| 10 | The rele-vance of different open innovation strategies for R&D per-formers显示文摘 | LIUIS S MARIA J N ANDRES BARGE-GIL | 2010 | Cuadernosde Economiay Direcciondela Empre-sa2010，13，45： | 1 |
| 11 | Gelcasting of sintered reaction bonded silicon nitride for improved mechanival properties 显示文摘 | Maria J P Kiggans J O Tiegs T N | 1995 | Ceramic Engineer Science Proceeding1995，，： | 1 |
| 12 | Stress relaxation behavior of organically modified montmorillonite filled natural rubber/nitrile rubber nanocomposites显示文摘 | Maria H J Lyczko N Nzihou A | 2014 | Applied Clay Science2014，87，： | 1 |
| 13 | Gelcasting of sintered reaction bonded silicon nitride for improved mechanical properties 显示文摘 | MARIA J P KIGGANS J O TIEGS T N | 1995 | Ceram Eng Sci Proc1995，16，5： | 1 |
| 14 | Histology and Ultrastructure of the Hepatopancreas of the Tigerfish, Hydrocynus yorskahlii 显示文摘 | Geyer H J Maria M N Swanepoel J H | 1996 | Journal of Morphology1996，227，： | 1 |
| 15 | Synthesis and evaluation of new ethyl 2,3 dihydrc-3-oxoisothiazolo pyridine-2 alkanoate derivatives as potential herbicides显示文摘 | MARIA J G JOSE M Z JAVIER N | 1997 | Pesticide Science1997，49，2： | 1 |
| 16 | Application of RFID technologies in the temperature mapping of the pineapple supply chain 显示文摘 | Amador C Emond J P Maria C N N | 2009 | Sensing and Instrumentation for Food Quality and Safety2009，3，1： | 1 |
| 17 | Numerical and experimental study of natural convection in tilted parallelepiped cavities for large Rayleigh numbers显示文摘 | Bairi A Laraqi N Garcia de Maria J M | 2007 | Experimental Thermal And Fluid Science2007，31，： | 1 |
| 18 | Application of real-time PCR on the development of molecular markers and to evaluate critical aspects for olive oil authentication显示文摘 | Maria J Giménez Fernando Pistón Antonio Mart-ín | 2010 | Food Chemistry2010，118，： | 1 |
| 19 | DDT化合物和PCB在富营养和贫营养湖中的季节性变化及其与藻类生物量之关系显示文摘1996~1997期间,在一个富营养湖(湖E)和一个贫营养湖(湖O)中进行了富营养化和有机污染物(PCB,DDTs及γ-HCH)的交互作用研究,两湖的地貌形态和水化学相似。集水区的土壤样品表明两湖暴露于相似的大气条件下。与湖O相比湖E没有观测到生物稀释。湖E的沉积物(1.5倍)、表面沉积物(1.4倍)和河鲈(Perca fluviatilis)(2.4倍)的有机碳和脂质物质中的PCB水平较高,并且微粒的沉降流较大,沉积物捕集器和沉淀物表面PCB的水平也较高。湖E中PCB的大部分转运主要是靠浮游植物。DDD/DDE比值较高似乎与p,p’-DDT的高负载相关而非厌氧的原因。所记录的湖O深层沉积岩心的高DDD/DDE比值和sDDT的高水平以及在此期间沉积最多,大概是由于从集水区流入的前体DDT最高的缘故。 | Maria Sderstrm Kerstin Nylund Ulf Jrnberg Gran Lithner Gran Rosén Henrik Kylin 邵平 樊恩源 | 2000 | AMBIO-人类环境杂志2000，29，4： | 1 |
| 20 | An electronically tunable microstrip bandpass filter using thin-film barium-strontium-titanate (BST) varactors显示文摘 | GHOSH J N D MARIA J P KINGON A I | 2005 | IEEE Trans Microwave Theory Tech2005，53，9： | 1 |
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