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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Inhibition of Desuvovibrio gigas hydrogenase with copper salts and other metalions显示文摘 | VICTOR M F MARIA L R PRESENTACION R | 1989 | European Journal of Biochemistry1989，185，2： | 1 |
| 3 | Processof Lemongrass Essential oil: Physicochemical Characteriza-tion and Assessment Quality of the Distillate and the ResidueProducts 显示文摘 | LAURA P T GLAUCIA M F P MARIA R W | 2011 | Industrial & Engineering Chemistry Research2011，50，13： | 1 |
| 4 | 限饲和再投喂对不同日龄鸡消化酶促反应的影响显示文摘试验旨在评价限饲和再投喂对两个不同日龄(7和35d)鸡酶活性和胃肠道器官重量的影响,在每种日龄下,鸡被限饲70%(30%自由采食)7d,然后自由采食3d。对照组自由采食10d。对胰腺中糜蛋白酶、胰蛋白酶、淀粉酶、脂肪酶活性和小肠中蔗糖酶、麦芽糖酶的活性进行分析,并且测量了腺胃、肌胃、小肠和大肠的重量。在14d,与对照组相比,限饲组的胰蛋白酶、淀粉酶活性均降低,但在42d,与对照组相比,限饲组蔗糖酶活性降低,表明限饲对酶活性的影响与日龄有关。限饲可以降低完成期(42d)各器官的重量。日龄35~42d的鸡,在再投喂后,器官重量增加,并且达到与对照组一致。在起始期(14d),腺胃和肌胃受限饲的影响很小,在完成期,肌胃也是受影响最小的器官,而小肠时受影响最严重。限饲的所有影响在恢复饲喂3d后被逆转,表明这种改变时快速且可逆的,并且限饲和再投喂与年龄有关。 | Cristiane R A Duarte Maria L M Vicentini P Pinheiro D F | 2014 | 饲料博览2014，0，10： | 1 |
| 5 | MR dacryocystography:comparison with dacryocystography and CT dacryocystography显示文摘 | Manfrè L de Maria M Todaro E Mangiameli A Ponte F Lagalla R | | 0，，06： | 1 |
| 6 | Nile Tilapia ( Oreochromis niloticus), Liver Morphology, CYP1A Activity and Thyroid Hormones After Endosulfan Dietary Exposure 显示文摘 | ANA M C ANTONIO F F MARIA A R | 2007 | Pesticide Biochemistry and Physiology2007，89，3： | 1 |
| 7 | Study of Some Physical Properties of Biodegradable Films Based on Blends of Gelatin and Poly( vinyl alcohol) using a Response-surface Methodology显示文摘 | Carvalho R A Maria T M C Moraes I C F | 2009 | Materials Science and Engineering C2009，29，： | 1 |
| 8 | Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells显示文摘 | Mereedes G B Maria F R Monica G M | 2006 | Virology2006，349，： | 1 |
| 9 | A reagent less fluorescent sol-gel biosensor for uric acid detection in biological fluids显示文摘 | David M P Maria L F Mateo C R | 2003 | Analytical Biochemistry2003，2，322： | 1 |
| 10 | 查看详情显示文摘 | Aline R B Emilene M B Celine L Maria G R V Sergio L C F Bernhard W | | 0，，： | 1 |
| 11 | Arabidopsis and tobacco plants ectopically expressing the soybean antiquitin-like ALDH7 gene display enhanced tolerance to drought,salinity,and oxidative stress显示文摘 | Simone M R Maxuel O A Ana P S G Fabio M D Maria C B P Elizabeth P B F | | 0，，： | 1 |
| 12 | Determination of polybrominated diphenyl ethers in water and soil samples by cloud point extraction-ultrasound-assisted back-extraction-gas chromatography-mass spectrometry显示文摘 | FONTANA A R MARIA F SILVA M F | 2009 | Journal of Chromatography A2009，1216，20： | 1 |
| 13 | Thermal protection of β-carotene in re- assembled casein micelles during different processing technologies applied in food industry 显示文摘 | Maria S Carolina G F Ana M R | 2013 | Food Chemistry2013，138，： | 1 |
| 14 | Identification and characterization of potentially algal-lytic marine bacteria strongly associated with the toxic dinoflagellate显示文摘 | ANA M A MARIA S F SANDRA R O | 2005 | Journal of Eukaryotic Microbiology2005，52，3： | 1 |
| 15 | Study of some physical proper- ties of biodegradable films based on blends of gelatin and poly( vinyl alcohol) using a response - surface methodology 显示文摘 | Carvalho R A Maria T M C Moraes I C F | 2009 | Materials Science and Engineering C2009，29，： | 1 |
| 16 | Extender and cryoprotectants for cooling and freezing of piracanjuba(Brycon orbignyanus) semen,an endangered Brazilian teleost fish显示文摘 | MARIA A N VIVERIOS A T M FREITAS R T F | 2006 | Aquaculture2006，26，14： | 1 |
| 17 | Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells显示文摘 | Mercedes G B Maria F R Monica G M | 2006 | Virology2006，349，： | 1 |
| 18 | Incorporation of public hospitals: a ''Silver Bullet' against overeapaeity, manageri',d bottle- necks and resouree constraints Case studies from Austria and Estonia 显示文摘 | Attain H F Reinhard R H Maria M H et d | 2007 | Health Pulicy2007，81，： | 1 |
| 19 | Classification and determination of total protein in milk powder using near infrared reflectance spectrometry and the successive projections algorithm for variable selection显示文摘 | MARIA R C I MARIA F V M KESSIO M G L | 2011 | Vibrational Spectroscopy2011，57，2： | 1 |
| 20 | Sulphur retention during co-combustion of coal and sewage sludge显示文摘 | BELEN F M MARIA D R JORGE X | 2004 | Fuel2004，83，10： | 1 |
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