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| 1 | Long noncoding RNAs:a missing link in osteoporosis显示文摘Osteoporosis is a systemic disease that results in loss of bone density and increased fracture risk,particularly in the vertebrae and the hip.This condition and associated morbidity and mortality increase with population ageing.Long noncoding(lnc)RNAs are transcripts longer than 200 nucleotides that are not translated into proteins,but play important regulatory roles in transcriptional and post-transcriptional regulation.Their contribution to disease onset and development is increasingly recognized.Herein,we present an integrative revision on the studies that implicate lncRNAs in osteoporosis and that support their potential use as therapeutic tools.Firstly,current evidence on lncRNAs involvement in cellular and molecular mechanisms linked to osteoporosis and its major complication,fragility fractures,is reviewed.We analyze evidence of their roles in osteogenesis,osteoclastogenesis,and bone fracture healing events from human and animal model studies.Secondly,the potential of lncRNAs alterations at genetic and transcriptomic level are discussed as osteoporosis risk factors and as new circulating biomarkers for diagnosis.Finally,we conclude debating the possibilities,persisting difficulties,and future prospects of using lncRNAs in the treatment of osteoporosis. | Andreia Machado Silva Sara Reis Moura JoseHenrique Teixeira Mario Adolfo Barbosa Susana Gomes Santos Maria Ines Almeida | 2019 | Bone Research2019，7，1： | 13 |
| 2 | Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver显示文摘AIM To evaluate the effects of chronic exposure to ethanol in the liver and the expression of inflammatory genesin zebrafish.METHODS Zebrafish(n = 104),wild type,adult,male and female,were divided into two groups:Control and ethanol(0.05 v/v).The ethanol was directly added into water;tanks water were changed every two days and the ethanol replaced.The animals were fed twice a day with fish food until satiety.After two and four weeks of trial,livers were dissected,histological analysis(hematoxilineosin and Oil Red staining) and gene expression assessment of adiponectin,adiponectin receptor 2(adipor2),sirtuin-1(sirt-1),tumor necrosis factor-alpha(tnf-a),interleukin-1b(il-1b) and interleukin-10(il-10) were performed.Ultrastructural evaluations were conducted at fourth week.RESULTS Exposing zebrafish to 0.5% ethanol developed intense liver steatosis after four weeks,as demonstrated by oil red staining.In ethanol-treated animals,the main ultrastructural changes were related to cytoplasmic lipid particles and droplets,increased number of rough endoplasmic reticulum cisterns and glycogen particles.Between two and four weeks,hepatic mR NA expression of il-1b,sirt-1 and adipor2 were upregulated,indicating that ethanol triggered signaling molecules which are key elements in both hepatic inflammatory and protective responses.Adiponectin was not detected in the liver of animals exposed and not exposed to ethanol,and il-10 did not show significant difference.CONCLUSION Data suggest that inflammatory signaling and ultrastructural alterations play a significant role during hepatic steatosis in zebrafish chronically exposed to ethanol. | Ana Claudia Reis Schneider Cleandra Gregório Carolina Uribe-Cruz Ranieli Guizzo Tais Malysz Maria Cristina Faccioni-Heuser Larisse Longo Themis Reverbel da Silveira | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 3 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 4 | Advances in enhanced biological phosphorus removal: From micro to macro scale显示文摘 | Adrian Oehmen Paulo C. Lemos Gilda Carvalho Zhiguo Yuan Jürg Keller Linda L. Blackall Maria A.M. Reis | 2007 | Water Research2007，，11： | 3 |
| 5 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulh?es Aranha Lílian Terezinha Costa Cecília Vilani Lídia ágata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Fer | 2009 | Fuel Processing Technology2009，，9： | 1 |
| 6 | Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil显示文摘 | Marcos Tucunduva de Faria Michael S. Calderwood Daniel A. Athanazio Alan J.A. McBride Rudy A. Hartskeerl Martha Maria Pereira Albert I. Ko Mitermayer G. Reis | 2008 | Acta Tropica2008，，1： | 1 |
| 7 | Performance of radar absorbing materials by waveguide measurements for X-and Ku-band frequencies显示文摘 | Magali Silveira Pinho Maria Luisa Gregori Regina Celia Reis Nunes | 2002 | European Polymer Journal2002，38，： | 1 |
| 8 | Serological screening and toxoplasmosis exposure factors among pregnant women in the Democratic Republic of Sao Tome and Principe显示文摘 | Chien-Ching Hung Chia-Kwung Fan Kua-Eyre Su Fung-Chang Sung Hung-Yi Chiou Vilfrido Gil Maria da Conceicao dos Reis Ferreira Jose Manuel de Carvalho Claudina Cruz Yu-Kuan Lin Lian-Fen Tseng Ke-Yun Sao Wen-Cheun Chang Hung-Shue Lan Shing-Hsien Chou | 2006 | Transactions of the Royal Society of Tropical Medicine and Hygiene2006，，2： | 1 |
| 9 | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submitted to aerobic dynamic feeding 显示文摘 | Paulo C Lemos Luisa S Serafim Maria A M Reis | 2006 | Journal of Biotechnology2006，122，： | 1 |
| 10 | Expression of Heparanase Isoforms in Intervertebral Discs Classified According to Pfirrmann Grading System for Disc Degeneration显示文摘 | Luciano Miller Reis Rodrigues Lilian Zerbinatti de Oliveira Maria Aparecida da Silva Pinhal | 2013 | Spine2013，，13： | 1 |
| 11 | Degradation characteristics of hydroxyapatite coatings on orthopaedic TiAlV in simulated physiological media investigated by electrochemical impedance spectroscopy显示文摘 | Ricardo M Soutoa Maria M Lazb Rui L Reis | 2003 | Biomaterials2003，24，23： | 1 |
| 12 | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submitted to aerobic dynamic feeding显示文摘 | Paulo C. Lemos Luísa S. Serafim Maria A.M. Reis | 2005 | Journal of Biotechnology2005，，2： | 1 |
| 13 | Synthesis of polyhydroxyalkanoates from different short-chain fatty acids by mixed cultures submilted to aerobic dynamic feeding显示文摘 | Lemos P C Serafim S Maria A M Reis | 2006 | Journal of Bioteehnology2006，122，2： | 1 |
| 14 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 15 | MicroRNA history: Discovery, recent applications, and next frontiers显示文摘 | Maria I. Almeida Rui M. Reis George A. Calin | 2011 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2011，，1： | 1 |
| 16 | MYC-microRNA-9-metastasis connection in breast cancer显示文摘 | Maria Ines Almeida Rui M Reis George A Calin | 2010 | Cell Research2010，20，6： | 1 |
| 17 | Denitrifying phosphorus removal: Linking the process performance with the microbial community structure显示文摘 | Gilda Carvalho Paulo C. Lemos Adrian Oehmen Maria A.M. Reis | 2007 | Water Research2007，，19： | 1 |
| 18 | ID7 Isolated from Bauhinia variegata Stem Inhibits Tumor Progression and Metastatic Mechanisms of Triple Negative Breast Cancer in Vivo显示文摘Background:The breast cancer has been the most common form of cancer among women.The triple negative subtype represents 20%of all breast cancer cases in the world and is standing out by affecting young women and being aggressive.The main cause of death of patients with cancer is due to metastasis,which can reach the liver and lungs.Objective:The activities of ID7 fraction of the stems of Bauhinia variegata L.on breast cancer,lung metastasis and liver inflammatory process were evaluated.Method:ID7 was characterized by mass-spectrometry.The viability of murine mammary cells(4T1)treated with ID7 was assessed by MTT,trypan blue and fluorescence assay and viability of BT-20,MDA-MB-231 and MCF-7 human breast cancer tumor lines by MTS.The cell migration,invasion using matrigel and adhesion were performed.The expression of cell death proteins was quanitified by western blot and the gelatinases by zimogram.The ID7 activity of the tumor(4T1)and metastatic progession in vivo was evaluated.Results:ID7 reduced the 4T1 and MDA-MB-231viability and increased the late apoptosis,inhibited the 4T1 migration and invasion,increased the 4T1 adhesion and decreased the secreted active gelatinases.ID7 also increased the expression of PARP,caspase-7 and caspase-8,RIP and TNF-R1.In vivo,the ID7 decreased the volume and weight of the tumors and decreased lung metastasis and inflammation in the liver.The characterization showed mainly the presence of oleic acid,myricetin,quercetin and kaempferol in ID7.Conclusion:Thus,it was found that ID7 fraction exhibits selective antitumor and on the mechanisms of breast cancer metastasis activity,preventing lung metastasis and inflammation in the liver.It is suggested that fatty acids and flavonoids are correlated with such activities. | Kamilla Monteiro dos Santos Izabela Natalia Faria Gomes Renato JoséSilva Oliveira Fernanda E.Pinto Bruno Oliveira Fabrício P.Batista Rafael Cesar Russo Chagas Hélio B.Santos Ralph G.Thomé Wanderson Romao Rui Manuel Reis Maria Luiza Vilela Oliva Rosy Iara Maciel de Azambuja Ribeiro | 2019 | Journal of Pharmacy and Pharmacology2019，7，7： | 1 |
| 19 | Microbial population response to changes of the operating conditions in a dynamic nutrient-removal sequencing batch reactor显示文摘 | Filomena Freitas Margarida Temudo Maria A. M. Reis | 2005 | Bioprocess and Biosystems Engineering2005，，3： | 1 |
| 20 | Non-isothermal sinter-crystallization of jagged Li 2 O–Al 2 O 3 –SiO 2 glass and simulation using a modified form of the Clusters model显示文摘 | Viviane O. Soares Raphael C.V.M. Reis Edgar D. Zanotto Maria J. Pascual Alicia Durán | 2012 | Journal of Non-Crystalline Solids2012，，23： | 1 |
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