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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Langerhans cells utilize CDla and langerin to efficiently present nonpeptide antigens to T cells显示文摘 | Robert E H Peter A S Maria T | 2004 | J Clin Invest2004，113，5： | 1 |
| 3 | Case-control study on infant mortality in southern Brazil 显示文摘 | Karina G M Maria T A O Costa J S D | 2006 | Revista de saude publica2006，40，2： | 1 |
| 4 | One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in Brazilian patients with peptic ulcer显示文摘AIM: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer.METHODS: One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment.RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P>0.05). By per protocol analysis, the eradication rates were 80% and 83%,respectively, in patients treated for 1 or 2 wk (P>0.05). Nine patients (8.2%) reported minor side effects. CONCLUSION: One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for treatment of H pylori infection, andappears to be comparable to the 2-wk regimen in terms of efficacy. | Maria Aparecida Mesquita S(o|^)nia Letícia Silva Lorena Jazon Romilson Souza Almeida Ciro Garcia Montes Fábio Guerrazzi Luciana T Campos José Murilo Rubiota Zeitune | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 5 | AFLP molecular markers for resistance to melamp sora larici-populina in poplar显示文摘 | NARIJKE S | 1996 | Environmental and social issues in Poplar and Willow cultivation and utilization1996，1，： | 1 |
| 6 | Urokinase plasminogen activator, uPA receptor and its inhibitor in vernal keratoconjunctivitis显示文摘 | ANDREA L PAOLA B MARIA T S | 2005 | Invest Ophthalm Vis Sci2005，46，： | 1 |
| 7 | Isolation and some properties of collagen from the backbone of baltic cod (Gadus morhua) 显示文摘 | ELZBIETA Z MARIA S MAGDALENA T | 2010 | Food Hydrocolloids2010，24，4： | 1 |
| 8 | MCM41 functionalized with ethylenediaminetriacetic acid for ion-exchange chromatography 显示文摘 | Maria C B Corrado S Anna M T | 2011 | Journal of Materials Chemistry2011，21，： | 1 |
| 9 | A genetic algorithm for solving a capacitated P - median problem 显示文摘 | ELON S C MARIA T A S ALEX A F | 2003 | Numeric Algorithm2003，35，4： | 1 |
| 10 | The ADH3 * 2 and CYP2E1 Calleles increase the risk of alcoholism in Mexican American men显示文摘 | Konishi T Maria Calvillo M Leng A S | 2003 | Experimental and Molecular Pathology2003，74，： | 1 |
| 11 | Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephacon显示文摘 | Uincent T Maria S Brian GC | 1999 | Dev Biol1999，208，23： | 1 |
| 12 | Aerobic Denitrifying Bacteria that Produce Low Levels of Nitrous Oxide显示文摘 | Naoki T Maria A B Catalan S | 2003 | Applied and Environemntal Microbiology2003，69，6： | 1 |
| 13 | Microwave reduction of a nickeliferous laterite ore 显示文摘 | MICHAIL S MARIA T RON H | 2012 | Minerals Engineering2012，34，： | 1 |
| 14 | Endogenous salicylic acid potentiates cadmium-induced oxidative stress in Arabidopsis thalia显示文摘 | Myriam S Z Maria D G Maria L T | 2007 | Plant Science2007，173，2： | 1 |
| 15 | Transmission of Schistosoma japonicum by humans and domestic animals in the Yangtze River valley, Anhui province, China 显示文摘 | Wang T P Maria Vang Johansen Zhang S Q | 2005 | Acta Tropica2005，96，： | 1 |
| 16 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 17 | Formation and properties of a synthetic bone composite: Hydroxyapatite-collagen显示文摘 | Roger I M Maria K | 1995 | Journal of Biomedical Materials Research1995，29，： | 1 |
| 18 | AFLP molecular markers for resistance to melamp sora larici-populina in poplar显示文摘 | Maria T C Narijke S | 1996 | Environmental and social issues in Poplar and Willow cultivation and utilization1996，，1： | 1 |
| 19 | Acetylcholinesterase-based biosensors for quantification of carbofuran,carbaryl,methylparaoxon,and dichlorvosin 5% acetonitrile显示文摘 | GABRIELA V R MONTSERRAT C MARIA T R S | 2008 | Anal Bioanal Chem2008，392，： | 1 |
| 20 | In vitro biocompatibility evalua-tion of surface-modified titanium alloys显示文摘 | Cristina T Maria M Maria S | 2010 | Biomed Mate Res2010，4，： | 1 |
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