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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Accuracy of Orbscan pachymetry measurements and DHG ultrasound pachymetry in primary laser in situ keratomileusis and LASIK enhancement procedures显示文摘 | Nader G Iskander Ellen Anderson Penno N.Timothy Peters Howard V Gimbel Maria Ferensowicz | 2001 | Journal of Cataract & Refractive Surgery2001，，5： | 2 |
| 3 | Characterization and remediation of soils contaminated with uranium显示文摘 | MARIA G LUCIAN V P IGOR C | 2009 | Journal of Hazardous Materi- als2009，163，： | 1 |
| 4 | Screening analysis of beer ageing using near infrared spectroscopy and the successive projections algorithm for variable selection显示文摘 | MAHDI G V SEYED S M MARIA L R M | 2012 | Talanta2012，89，1： | 1 |
| 5 | Capillary electrophoresis of free fatty acids by indirect uhraviolet 显示文摘 | Maria V B Aaron E D Maria J L G | 2011 | Journal of Agriculture and Food Chemistry2011，59，10： | 1 |
| 6 | Mandarin peel wastespretreatment with steam explosion for bioethanol production显示文摘 | MARIA B A LIDIA G V FAYINY P G C | 2010 | Bioresource Technology2010，101，10： | 1 |
| 7 | Environment,tourism and land use planning-Riachinho Basin,Brazil显示文摘 | Maria G P Leila N M V Alexandre U | 2001 | Environmental Management and Health2001，12，1： | 1 |
| 8 | Capillary e- lectrophoresis of free fatty acids by Indirect ultraviolet detection: application to the classification of vegetable oils according to their botanical origin显示文摘 | Maria V B Aar6n E D Jests L G M | 2011 | Food Chem- istry2011，59，10： | 1 |
| 9 | Characterization of acetic acid bacteria in“traditional balsamic vinegar”显示文摘 | MARIA G CINZIA C LUCIANA D V | 2006 | International Journal of Food Microbiology2006，106，2： | 1 |
| 10 | Sequence structure of 12 novel Y chromosome microsatellites and PCR amplification strategies显示文摘 | Annabel G N Mike E Maria V L | 2001 | Forensic Sci Int2001，122，： | 1 |
| 11 | Growth and hatching dates of juvenile pacific sardine Sardinops caeruleus in the Gulf of California显示文摘 | CASIMIRO Q V MANUEL OTILIO N M MARIA GEORGINA G M | 2000 | Fisheries Research2000，48，2： | 1 |
| 12 | Microcystin-LR,-RR,-YR and-LA in water samples and fishes from a shallow lake inArgentina显示文摘 | Maria V A Lucas N G Nicolas G | 2010 | Harmful Algae2010，9，： | 1 |
| 13 | Zirconium carbide thin films deposited by pulsed laser ablation显示文摘 | ALESSIO L D SANTAGATA A TEGHIL R ZACCAGNINO M ZACCARDO I MAROTTA V FERRO D MARIA G D | 2000 | Appl Surf Sci2000，168，14： | 1 |
| 14 | Response surface methodology in the development of a stacking - sensitive capillary electrophoresis method for the analysis of tricyclic antidepressantsin human serum显示文摘 | Teresa G D Maria Isabel A V Nielene M D | 2005 | Eleetrophoresis2005，26，： | 1 |
| 15 | Congenital and acquired anomalies of the portal venous systerm显示文摘 | Carmen G Maria V Pilar M | 2002 | Radiographics2002，22，1： | 1 |
| 16 | Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid显示文摘 | Ulises G R Humberto B Maria Jose H V | 2012 | Antimicrob Chemother2012，67，7： | 1 |
| 17 | Direct numerical simulation of particle wall transfer and deposition in upward turbulent pipe flow显示文摘 | CRISTIAN M ANDREA G MARIA V S | 2003 | International Journal of MultiphaseFlow2003，29，： | 1 |
| 18 | Growth, feed efficiency and condition of common Octopus fed two formulated moist diets显示文摘 | Jesus C V Maria D H Felipe A G | 2008 | Aquaculture2008，275，： | 1 |
| 19 | Prevalence of Shigella enterotoxins 1 and 2 among Shigella strains isolated from patients with traveler's diarrhea显示文摘 | Martha V Joaquim G Maria TJ | 1999 | J Clin Microbiol1999，37，11： | 1 |
| 20 | 查看详情显示文摘 | Aline R B Emilene M B Celine L Maria G R V Sergio L C F Bernhard W | | 0，，： | 1 |
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