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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | 气象卫星云图的多分辨小波分解及人工神经网络降水估计研究显示文摘采用多分辨小波分析对卫星图象进行预处理 ,在保留其特征信息的同时 ,减小了数据量 ,改善了神经网络训练过程的收敛性能 ,提高了处理速度。采用这一方法根据 GOES- 8的红外亮温图象和气象雷达资料对巴西圣保罗州中部的降水量估计进行了试验 ,取得了良好的效果。 | 李伟钢 Maria C V Ramirez Nelson J Ferreira 石立华 Leonardo D de A Sá | 2000 | 南京气象学院学报2000，23，2： | 13 |
| 3 | A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes显示文摘AIM:To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes.METHODS:Silybin-phospholipid complex containing vitamin E(Realsil) was daily administered by gavage(one pouch diluted in 3 mL of water and containing 15 mg vitamin E and 47 mg silybin complexed with phospholipids) to rats fed a choline-deprived(CD) or a high fat diet [20% fat,containing 71% total calories as fat,11% as carbohydrate,and 18% as protein,high fat diet(HFD)] for 30 d and 60 d,respectively.The control group was fed a normal semi-purified diet containing adequate levels of choline(35% total calories as fat,47% as carbohydrate,and 18% as protein).Circulating and hepatic redox active and nitrogen regulating molecules(thioredoxin,glutathione,glutathione peroxidase),NO metabolites(nitrosothiols,nitrotyrosine),lipid peroxides [malondialdehyde-thiobarbituric(MDA-TBA)],and pro-inflammatory keratins(K-18) were measured on days 0,7,14,30,and 60.Mitochondrial respiratory chain proteins and the extent of hepatic fatty infiltration were evaluated.RESULTS:Both diet regimens produced liver steatosis(50% and 25% of liver slices with CD and HFD,respectively) with no signs of necro-inflammation:fat infiltration ranged from large droplets at day 14 to disseminated and confluent vacuoles resulting in microvesicular steatosis at day 30(CD) and day 60(HFD).In plasma,thioredoxin and nitrosothiols were not significantly changed,while MDA-TBA,nitrotyrosine(from 6 ± 1 nmol/L to 14 ± 3 nmol/L day 30 CD,P < 0.001,and 12 ± 2 nmol/L day 60 HFD,P < 0.001),and K-18(from 198 ± 20 to 289 ± 21 U/L day 30 CD,P < 0.001,and 242 ± 23 U/L day 60 HFD,P < 0.001) levels increased significantly with ongoing steatosis.In the liver,glutathione was decreased(from 34.0 ± 1.3 to 25.3 ± 1.2 nmol/mg prot day 30 CD,P < 0.001,and 22.4 ± 2.4 nmol/mg prot day 60 HFD,P < 0.001),while thioredoxin and glutathione peroxidase were initially increased and then decreased.Nitrosothiols were constantly increased.MDA-TBA levels were five-fold increased from 9.1 ± 1.2 nmol/g to 75.6 ± 5.4 nmol/g on day 30,P < 0.001(CD) and doubled with HFD on day 60.Realsil administration significantly lowered the extent of fat infiltration,maintained liver glutathione levels during the first half period,and halved its decrease during the second half.Also,Realsil modulated thioredoxin changes and the production of NO derivatives and significantly lowered MDA-TBA levels both in liver(from 73.6 ± 5.4 to 57.2 ± 6.3 nmol/g day 30 CD,P < 0.01 and from 27.3 ± 2.1 nmol/g to 20.5 ± 2.2 nmol/g day 60 HFD,P < 0.01) and in plasma.Changes in mitochondrial respiratory complexes were also attenuated by Realsil in HFD rats with a major protective effect on Complex Ⅱ subunit CII-30.CONCLUSION:Realsil administration effectively contrasts hepatocyte fat deposition,NO derivatives formation,and mitochondrial alterations,allowing the liver to maintain a better glutathione and thioredoxin antioxidant activity. | Ignazio Grattagliano Catia V Diogo Maria Mastrodonato Ornella de Bari Michele Persichella David QH Wang Adriana Liquori Domenico Ferri Maria Rosaria Carratù Paulo J Oliveira Piero Portincasa | 2013 | World Journal of Gastroenterology2013，19，20： | 6 |
| 4 | Pharmacological properties of Anagallis arvensis L. (“scarlet pimpernel”) and Anagallis foemina Mill. (“blue pimpernel”) traditionally used as wound healing remedies in Navarra (Spain)显示文摘 | Víctor López Anna K. J?ger Silvia Akerreta Rita Yolanda Cavero Maria Isabel Calvo | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 5 | Escherichia coli AspP activity is enhanced by macromolecular crowding and by both glucose-1, 6-bisphosphate and nucleotide-sugars 显示文摘 | Maria T M Z Alejandro M V Francisco J M | 2007 | FEBS Lett2007，581，5： | 1 |
| 6 | Capillary electrophoresis of free fatty acids by indirect uhraviolet 显示文摘 | Maria V B Aaron E D Maria J L G | 2011 | Journal of Agriculture and Food Chemistry2011，59，10： | 1 |
| 7 | Biological Response Modifier Activity of an Exopolysaccharide from Paenibacillus jamilae CP-7显示文摘 | Alfonso R B Maria J V Encarnacion M | 2001 | Clinical and Diagnostic Laboratory Immunology2001，8，4： | 1 |
| 8 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 9 | An ant colony optimization algorithm for DNA sequencing by hybridization显示文摘 | MATEU Y V MARIA J B | 2008 | Computers and Operations Research2008，35，11： | 1 |
| 10 | Effect of type of anodic arrangements on efficiency of electrochemical chloride removal from concrete显示文摘 | Miguel A C Maria J S Guillem v | 2006 | ACI Mater J2006，103，4： | 1 |
| 11 | The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish显示文摘 | Stefan H O Maria V F Chris J H | 2011 | Dis Mod Meehan2011，4，6： | 1 |
| 12 | Fog water collection in a rural park in the Canary Islands(Spain)显示文摘 | MARIA V MARZOL J | 2002 | Atmospheric Research2002，64，： | 1 |
| 13 | Species association increases biofilm resistance to chemical and mechanical treatments 显示文摘 | Manuel S Lucia C S Maria J V | 2009 | Water Research2009，，43： | 1 |
| 14 | Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts 显示文摘 | Di Mambro Valeria M Fonseca Maria J V | 2005 | Journal of Pharmaceutical and Biomedical Analysis2005，37，2： | 1 |
| 15 | LDH-A inhibition,a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer (HLRCC)显示文摘 | HAN X VLADIMIR A V MARIA J M | | 0，，03： | 1 |
| 16 | Effect of type of anodic arrangements on efficiency of electrochemical chloride removal from concrete显示文摘 | Miguel A C Maria J S Guillem V | 2006 | ACI Materials Journal2006，103，4： | 1 |
| 17 | FPGA implementation of an OFDM-based WLAN receiver 显示文摘 | MARIA J C JAVIER V VICENC A JOSE M R | 2012 | Microprocessors and Microsystems2012，36，3： | 1 |
| 18 | Spatiotemporal evolution of soil pH and zinc after the aznalcollar mine spill显示文摘 | KARL V MARIA J P RAFAELA O | 2006 | Journal of Environmental Quality2006，35，1： | 1 |
| 19 | Hair analysis forΔ^9-THC,Δ^9-THC-COOH,CBN and CBD,by GC/MS-EI Comparison with GC/MS-NCI forΔ^9-THC-COOH显示文摘 | Maria J Paula V Estela G | 2002 | Forensic Science International2002，128，： | 1 |
| 20 | Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chromatography with electrochemical detection (HPLC-ECD) 显示文摘 | MARIA J G URSULA V CHRISTOPH H | 2007 | Pharmaceutical and Biomedical Analysis2007，43，： | 1 |
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