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| 1 | Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B显示文摘AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed.Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection criteria.Range of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 fibrosis.In total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow up.Predictors of CVS included lower baseline DNA level(P=0.001),hepatitis B virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting.Resistance and rebound rates are very low.This is similar to data from controlled and uncontrolled trials around the world. | Farzan Fahrtash-Bahin Viraj C Kariyawasam Timothy Gray Karen Byth Jacob George Mark W Douglas | 2013 | World Journal of Gastroenterology2013，19，5： | 5 |
| 2 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 3 | Radiation-Induced lung injury显示文摘 | Mark V Hendrick W Sheils C | 1999 | Clini Pul Med1999，6，5： | 2 |
| 4 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 5 | Growth of sculptured polymer submicronwire assemblies by vapor deposition显示文摘 | Scan Pursel Mark W Horn Melik C Demirel | 2005 | Polymer2005，46，： | 1 |
| 6 | The effect of allochthonous salt on the petroleum systems of northern Green Canyon and Ewing Bank (offshore Louisiana),northern Gulf of Mexico显示文摘 | Paul W Mark G R | 1998 | AAPG Bulletin1998，82，5： | 1 |
| 7 | Tillage effects on soil hydraulic properties in space and time:State of the science显示文摘 | Mark W S Timothy R G James C A | 2008 | Soil and Tillage Research2008，99，1： | 1 |
| 8 | Land plants and DNA barcodes:short-term and long-term goals显示文摘 | Mark W C Nicolas S Mike W | | 0，，9： | 1 |
| 9 | Mixed orthogonal frequen-cy coded SAW RFID tags 显示文摘 | Gallagher Mark W Malocha Donald C | 2013 | IEEE Trans on Ultrasonics Ferro-electrics and Frequency Control2013，60，3： | 1 |
| 10 | An Evaluation of Haptic Feedback Modeling during Industrial Design Practice显示文摘 | Mark E David W David C | 2005 | Design Studies2005，26，5： | 1 |
| 11 | Basin evolution in western Newfoundland:New insights from hydrocarbon exploration显示文摘 | Mark C John W Lan K | 2001 | AAPG2001，85，3： | 1 |
| 12 | The use of vacuum assisted closure therapy for lower-extremity wounds with exposed bone 显示文摘 | DeFranzo A J Argenta L C Marks M W | 2001 | Plast Reeonstr Surg2001，108，10： | 1 |
| 13 | Opportunities and challenges in targeting HIV entry显示文摘 | MARK J B THEODORE C P ROBERT W D | 2002 | Curr Opin Pharmacol2002，2，： | 1 |
| 14 | Pathogenesis of pain in chronic pancreatitis : ongoing enigma 显示文摘 | Bornman P C Marks I N Girdwood A W | 2003 | World J Surg2003，27，11： | 1 |
| 15 | Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes显示文摘 | Shimareet Kumar Lazlo Krenacs Jeffrey Medeiros Kojo S.J Elenitoba-Johnson Timothy C Greiner Lynne Sorbara Douglas W Kingma Mark Raffeld Elaine S Jaffe | 1998 | Human Pathology1998，，4： | 1 |
| 16 | General fuel cell hybrid synergies and hybrid system testing status 显示文摘 | Wolfgang W Pedro N Mark C Williams | 2006 | Journal of Power Sources2006，159，1： | 1 |
| 17 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
| 18 | The importance of the lumpectomy surgical margin status in long term results of breast conservation显示文摘 | Melanie C Kent W Mark J | 1995 | Cancer1995，76，2： | 1 |
| 19 | Circulation and mixing of water masses of tatar strait and the northwestern boundary region of the Japan Sea显示文摘 | STEPHEN C R MARK J W GENNADY I Y | 1999 | Journal of Oceanography1999，55，： | 1 |
| 20 | Access recirculation in temporary hemodialysis catheters as measured by the saline dilution technique显示文摘 | Mark A I Peter J C John J W | 2000 | Am J Kid Dis2000，36，6： | 1 |
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