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| 1 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Polybrominated diphenyl ether (PBDE) flame retardants显示文摘 | Frank Rahman Katherine H Langford Mark D Scrimshaw John N Lester | 2001 | Science of the Total Environment2001，，1： | 1 |
| 4 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 5 | Dual-curable unsaturated polyester inorganic/organic hybrid films显示文摘 | Ahmet N Teng G H Mark D S | 2006 | Journal of Applied Polymer Science2006，99，1： | 1 |
| 6 | Structure-property relationship of all-cellulose composites 显示文摘 | BENO J C ROGER H N MARK P S | 2009 | Comp Sci Tech2009，69，： | 1 |
| 7 | Analysis of Immobilized Cell Bioreactors for Desulfurization of Flue Gases and Sulfate/sulfate-laden Wastewater显示文摘 | Punjai T Selvaraj Mark H Little Eric N Kaufman | 1997 | Biodegradation1997，8，： | 1 |
| 8 | Lead(Pb+2)promotes apoptosis in newborn rat cerebellar neurons:path-ologic implications显示文摘 | OBERTO A MARKS N EVANS H L | 1996 | J Pharmacol Exp Ther1996，279，1： | 1 |
| 9 | Strategies for design and construc- tion of high - reflectance asphalt pavements 显示文摘 | Tran N Powell B Marks H | 2009 | Transportation Re- search Record: Journal of the Transportation Research Board2009，2098，1： | 1 |
| 10 | Lead (Pb2+ ) promotes apoptosis in newborn rat cerebellar neurons: pathological implications显示文摘 | Oberto A Marks N Evans H | 1996 | J PharmacolExpTher1996，279，： | 1 |
| 11 | Nuclear localization of NPR1 is required for activation of PR gene expression显示文摘 | Mark K K Fan W H Dong X N | 2000 | Plant cell2000，12，： | 1 |
| 12 | Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance显示文摘 | Scott H James Mark N Prichard | 2014 | Current Opinion in Virology2014，，： | 1 |
| 13 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 14 | Translocator protein (TSPO 18 kDa) is expressed by neural stem and neuronal precursor cells显示文摘 | Varga B Markó K Hádinger N | 2009 | Neurosci Lett2009，462，3： | 1 |
| 15 | inhibition of norepinephrine-induced eardiac hypertrophy in s10013 transgenic mice显示文摘 | TSOPORIS J N MARKS A KAHN H J | 1998 | J Clin Invest1998，102，8： | 1 |
| 16 | Trace element geo- chemistry of magnetite and pyrite in Fe oxide (q-/- Cu-Au) mineralised systems: Insights into the geochemistry of ore- forming fluids 显示文摘 | Carew M J Mark G Oliver N H S | 2006 | Geochimica Et Cosmochimica Acta2006，70，18： | 1 |
| 17 | Does Progressive Pancreatic Insufficiency Limit Pain in Calcific Pancreatitis with Duct Stricture or Continued Alcohol Insult?显示文摘 | A H Girdwood I N Marks P C Bornman R E Kottler M Cohen | 1981 | Journal of Clinical Gastroenterology1981，，： | 1 |
| 18 | Electroluminescence in conjugated polymers 显示文摘 | FRIEND R H GYMER R W HOLMES A B BURROUGHES J H MARKS R N TALIANI C BRADLEY D D C DOS SANTOS D A BREDAS J L LOGDLUND M SALANECK W R | 1999 | Nature1999，397，： | 1 |
| 19 | Polybrominated diphenyl ether (PBDE) flame retardants显示文摘 | ltahman Frank Langford Katherine H Scrimshaw Mark D Lester John N | 2001 | The Science of the Total Environment2001，275，： | 1 |
| 20 | The impact of a cap- tive insurance company' s formation on a film' s value after the carnation case显示文摘 | MARK C JOHN H WALLANCE N | 1987 | Journal of Business Research1987，15，4： | 1 |
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