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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | On the utility of gambling: extending the approach of meginniss 显示文摘 | Ng C T Luce R D Marley A A J | 2008 | Aequationes Mathematicae2008，76，： | 1 |
| 3 | Persulfate oxidation for in situ remediation of TCE (Ⅰ) Activated by ferrous ion with and without a persulfate-thiosulfate redox couple 显示文摘 | Liang C Bruell C J Marley M C | 2004 | Chemosphere2004，55，： | 1 |
| 4 | Utility of gambling I : entropy modified linear weighted utility 显示文摘 | Luce R D Ng C T Marley A A J | 2005 | Economic Theory2005，36，： | 1 |
| 5 | Utility of gambling II : risk, paradoxes, and data显示文摘 | Luce R D NgC T Marley A A J | 2008 | Economic Theory2008，36，： | 1 |
| 6 | Thermallyactivated persulfate oxidation of trichloroethylene(TCE)and 1,1,1-trichloroethane(TCA)in aqueous systems andsoil slurries显示文摘 | Liang C J Bruell C J Marley M C Sperry K L | 2003 | Soil and Sediment Contamination2003，12，3： | 1 |
| 7 | Persulfate oxidation for in situ remediation of TCE (Ⅱ) Activated by chelated ferrous ion显示文摘 | Liang C Bruell C J Marley M C | 2004 | Chemosphere2004，55，： | 1 |
| 8 | Thermally activated persulfate oxidation of trichloroethylene (TCE) and 1,1,1-trichloroethane (TCA) in aqueous system and soil slurries显示文摘 | LIANG C J BRUELL C J MARLEY M C | 2003 | Soil and Sediment Contamination2003，12，2： | 1 |
| 9 | In-depth review of atmospheric mercury: Sources, transformations, and potential sinks 显示文摘 | Gaffney J S Marley N A | 2014 | Energy and Emis- sion Control Technologies2014，2，： | 1 |
| 10 | Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells显示文摘 | Marley S Lewis J Schneider H | 2004 | Br J Haematol2004，125，4： | 1 |
| 11 | Thermally activated persulfate oxidation of Ttrichloroethylene(TCE) andl 1, 1, l-trichloroethane(TCA) in aqueous systems and soil slurries显示文摘 | Liang C J Bruel C J Marley M C | 2003 | Soil Sediment Contain2003，12，2： | 1 |
| 12 | Effect of root-knot nematodes on cajanol accumulation in the vascular tissues of pigeonpea after stem inoculation with Fusarium udum显示文摘 | MARLEY P S HILLOCKS R J | 1994 | Phytopathology1994，43，： | 1 |
| 13 | Risk-based inspection principles and their application to corroded pipelines显示文摘 | Bjomoy O H Marley M J Jephson N J | 2001 | Pipes and Pipelines International2001，46，5： | 1 |
| 14 | Targeting primary human leukaemia cells with RNA interference: Bcr-Abl targeting: inhibits myeloid progenitor self-renewal in chronic myeloid leukaemia cells 显示文摘 | WITHEY JM MARLEY SB KAEDA J | 2005 | BrJ Haematol2005，129，： | 1 |
| 15 | Laboratory studies of a low - damage corn - shelling Machine 显示文摘 | Mid F Al -Jalil Stephen J Marley MofazzalH Chowdhury | 1980 | TRANSACTION of the ASAE1980，9，3： | 1 |
| 16 | The application of in situ airsparging as an innovative soils and ground water remediation tech-nology显示文摘 | Marley M C Hazebrouck D J | 1992 | Ground Water Monitoring Rev1992，12，2： | 1 |
| 17 | The impact of combustion emission on air quality and climate from coal to biofuels and beyond显示文摘 | CAFFNEY J S MARLEY N A | | 0，，01： | 1 |
| 18 | The impact of hiogenic carbon sources on aerosol absorption in Mexico City显示文摘 | Marley N A Gaffney J S Tackett M | 2009 | Atmospheric Chemistry and Physics2009，9，5： | 1 |
| 19 | Bermard grofman:a general concept of majority rule显示文摘 | MARLEY A A J | 2002 | Mathematical Social Science2002，，43： | 1 |
| 20 | A comparison of the management of potentially malignant oral mucosal lesions by oral medicine practitioners and oral & maxillofacial surgeons in the UK显示文摘 | Marley J J Linden G J Cowan C G | 1998 | J Oral Pathol Med1998，27，10： | 1 |
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