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| 1 | Thromboembolic disease in patients with rheumatoid arthritis undergoing joint arthroplasty: Update on prophylaxes显示文摘The risk of venous thromboembolism(VTE) in rheumatoid arthritis(RA) and the higher incidence of RA patients undergoing major orthopedic surgery is well recognized. The objective of the present study is to describe the incidence of VTE and discuss the correct prophylaxis in RA patients undergoing knee or hip replacement. A systematic review of studies on thromboprophylaxis in RA patients undergoing major orthopedic surgery was performed. Detailed information was extracted to calculate the rate of VTE in RA orthopedic patients and analyze the thromboprophylaxis performed and bleeding complications. Eight articles were eligible for full review. No difference in the overall rate of VTE was observed between RA patients and controls. No significant differences were found in RA patients in terms of bleeding complications. The data on the optimal prophylaxis to be used in RA patients were insufficient to recommend any of the several options available. In the absence of dedicated guidelines for the care of RA patients undergoing orthopedic surgery,management must be individualized to obtain favorablepatient outcome, weighing up all the factors that might put the patient at risk for higher bleeding and thrombotic events. | Antonella Mameli Francesco Marongiu | 2014 | World Journal of Orthopedics2014，5，5： | 4 |
| 2 | Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection显示文摘AIM To address to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. METHODS The ability of the liver to regenerate is remarkable on both clinical and biological grounds. Basic mechanisms underlying this process have been intensively investigated. However, it is still debated to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. We addressed this issue using a genetically tagged system. We were able to follow the fate of single transplanted hepatocytes during the regenerative response elicited by 2/3 partial surgical hepatectomy(PH) in rats. Clusters of transplanted cells were 3D reconstructed and their size distribution was evaluated over time after PH. RESULTS Liver size and liver DNA content were largely recovered 10 d post-PH, as expected(e.g., total DNA/liver/100 gb.w. was 6.37 ± 0.21 before PH and returned to 6.10 ± 0.36 10 d after PH). Data indicated that about 2/3 of the original residual hepatocytes entered S-phase in response to PH. Analysis of cluster size distribution at 24, 48, 96 h and 10 d after PH revealed that about half of the remnant hepatocytes completed at least 2 cell cycles. Average size of hepatocytes increased at 24 h(248.50 μm2 ± 7.82 μm2, P = 0.0015), but returned to control values throughout the regenerative process(up to 10 d post-PH, 197.9 μm2 ± 6.44 μm2, P = 0.11). A sizeable fraction of the remnant hepatocyte population does not participate actively in tissue mass restoration. CONCLUSION Hyperplasia stands as the major mechanism contributing to liver mass restoration after PH, with hypertrophy playing a transient role in the process. | Fabio Marongiu Michela Marongiu Antonella Contini Monica Serra Erika Cadoni Riccardo Murgia Ezio Laconi | 2017 | World Journal of Gastroenterology2017，23，10： | 3 |
| 3 | Inhibition of blood coagulation activation and oral anticoagulants in patients with mechanical heart valve prostheses显示文摘 | Barcellona D Mameli G Marongiu F | 1996 | Thromb Res1996，81，3： | 2 |
| 4 | Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies显示文摘Preclinical and clinical studies indicate that synthetic psychoactive substances,in addition to having abuse potential,may elicit toxic effects of varying severity at the peripheral and central levels.Nowadays,toxicity induced by synthetic psychoactive substances poses a serious harm for health,since recreational use of these substances is on the rise among young and adult people.The present review summarizes recent findings on the peripheral and central toxicity elicited by “old” and “new” synthetic psychoactive substances in humans and experimental animals,focusing on amphetamine derivatives,hallucinogen and dissociative drugs and synthetic cannabinoids. | Giulia Costa Maria Antonietta De Luca Gessica Piras Jacopo Marongiu Liana Fattore Nicola Simola | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 5 | Coagulation in chronic atrial fibrillation显示文摘 | Meloni L Barcellona D Marongiu F | 1997 | Circulation1997，96，3： | 1 |
| 6 | Anti-HIV-1 integrase drugs:how far from the shelf显示文摘 | Pani A Marongiu ME | 2002 | Curr Pharm Des2002，6，： | 1 |
| 7 | Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin 显示文摘 | Gardenghi S Marongiu MF Ramos P | 2007 | Blood2007，109，11： | 1 |
| 8 | Supercritcal Carbon Dioxide Extraction and Characterization of Laurus nobilis Essential Oil显示文摘 | Caredda A Marongiu B Porcedda S | 2002 | J Agric Food Chem2002，50，6： | 1 |
| 9 | Coagulation in chronic atrial fibrillation 显示文摘 | Meloni L Barcellona D Marongiu F | 1997 | Circulation1997，96，3： | 1 |
| 10 | Thermal degradation of poly ( vinyl chloride ) 显示文摘 | MARONGIU A FARAVELLI T BOZZANO G | 2003 | Journal of Analytical and Applied Pyrolysis2003，70，2： | 1 |
| 11 | Placental stem cell correc- tion of murine intermediate maple syrup urine disease 显示文摘 | Skvorak KJ Dorko K Marongiu F | 2013 | Hepatol- ogy2013，57，3： | 1 |
| 12 | Production of hepatocyte like cells from human amnion显示文摘 | Miki T Marongiu F Ellis EC | 2009 | Methods Mol Bio12009，481，： | 1 |
| 13 | Supercritical CO2 extract of Cinnamomum zeylanicum:ehemical characterization and anti- tyrusinase activity 显示文摘 | MARONGIU B PIRAS A PORCEDDA S | 2007 | Journal of Agricultural and Food Chemistry2007，55，10： | 1 |
| 14 | Supercriticalcarbon dioxide extraction and characterization of Laurus nobilis essen-tial oil显示文摘 | CAREDDA A MARONGIU B PORCEDDA S | 2002 | Journal of Agricultural and Food Chemistry2002，50，6： | 1 |
| 15 | Supercritical Carbon Dioxide Extraction and Characterization of Laurus nobilis Essential Oil 显示文摘 | Caredda A Marongiu B Porcedda S | 2002 | J Agric Food Chem2002，50，6： | 1 |
| 16 | Differentiation of single cell derived human mesenchymal stem cells into cells with a neuronal phenotype:RNA and microRNA expression profile显示文摘 | Crobu F Latini V Marongiu MF | 2012 | Mol Biol Rep2012，39，4： | 1 |
| 17 | Supercritical Carbon Dioxide Extraction and Characterization of Laurus nobilis Essential Oil显示文摘 | Caredda A Marongiu B Porcedda S | 2002 | J Agric Food Chem2002，50，6： | 1 |
| 18 | Supercritical carbon dioxide extraction and characterization of Laurus nobilis essential oil显示文摘 | Caredda A Marongiu B Porcedda S | 2002 | J Agri Food Chem2002，50，： | 1 |
| 19 | Second- order sliding-mode control of DC drives 显示文摘 | Damiano A Gatto G L Marongiu I | 2004 | IEEE Trans- actions on Industrial Electronics2004，51，2： | 1 |
| 20 | Thermal degradation of poly(vinyl chloride)显示文摘 | Marongiu A Faravelli T Bozzano G | 2003 | J Anal Appl Pyrolysis2003，70，： | 1 |
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