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| 1 | Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review显示文摘Neuroendocrine carcinoma (NEC) of the extrahepatic bile duct is rare, and only 22 cases have been reported. Only two of these were large-cell NEC (LCNEC); the vast majority were small-cell NEC. Here, we report a third case of LCNEC of the extrahepatic bile duct. A 76-year-old male presented to a local hospital with painless jaundice. Imaging studies revealed a tumor at the hepatic hilum. The patient underwent right hepatic lobectomy, bile duct resection, and cholecystectomy. The resection specimen showed a 5.0-cm invasive neoplasm involving the hilar bile ducts and surrounding soft tissue. Histologically, the tumor consisted of nests of medium to large cells with little intervening stroma. The tumor invaded a large portal vein branch. All four excised lymph nodes were positive for metastasis, and metastatic deposits were also present in the gallbladder wall. The tumor was diffusely positive for synaptophysin and focally positive for chromogranin A. Approximately 70%-80% of the tumor cells were positive for Ki-67, indicating strong proliferative activity. A diagnosis of LCNEC was made. A few bile ducts within and adjacent to the invasive tumor showed dysplasia of the intestinal phenotype and were focally positive for synaptophysin and chromogranin A, suggesting that the dysplastic intestinal-type epithelium played a precursor role in this case. A postoperative computer tomography scan revealed rapid enlargement of the abdominal and retroperitoneal lymph nodes. The patient died 21 d after the operation. NEC of the bile duct is an aggressive neoplasm, and its biological characteristics remain to be better defined. | Eizaburo Sasatomi Michael A Nalesnik J Wallis Marsh | 2013 | World Journal of Gastroenterology2013，19，28： | 4 |
| 2 | Impurity induced disordering in InGaAs/InGaAlAs quantum wells using implanted fluorine and boron显示文摘 | Bryce A C Marsh J H Gwilliam R | 1991 | IEEE Proceeding-J1991，38，2： | 2 |
| 3 | Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya显示文摘 | Wendy P O'Meara Phillip Bejon Tabitha W Mwangi Emelda A Okiro Norbert Peshu Robert W Snow Charles RJC Newton Kevin Marsh | 2008 | The Lancet2008，，9649： | 2 |
| 4 | Effects of grading leniency and low workload on students' evaluations of teaching: popular myth, bias, validity, or innocent by standers显示文摘 | Roche L A | 2002 | Journal of Educational Psychology2002，92，1： | 1 |
| 5 | Hepatic resection and transplantation for peripheral cholangiocarcinoma显示文摘 | Casavilla F A Marsh J W Iwatsnki S | 1997 | J Am Col Surg1997，185，5： | 1 |
| 6 | Chemical Vapor Deposition of CooPer from Cu + 1 Pre-cursors in the Presence of WaterVapor显示文摘 | GELATOS A V MARSH R KOTTKE M | 1993 | Applied Physics Letters1993，63，20： | 1 |
| 7 | Response of Friction Damped Braced Frmms 显示文摘 | Pall A S and Marsh C | 1982 | Journal of the Structural Division ASCE1982，108，6： | 1 |
| 8 | Relationships between flow, self-concept, psychological skills, and performance 显示文摘 | JACKSON S A THOMAS P R MARSH H W | 2001 | Journal of Aoolied Soort Psvcholow2001，13，2： | 1 |
| 9 | Ionic liquids and their interaction with cellulose显示文摘 | Pinkert A Marsh K N Pang S | 2009 | Chem Rev2009，109，12： | 1 |
| 10 | Effect of a low glycemic index compared with a conventional healthy diet on polycystic ovary syndrome显示文摘 | Marsh K A Steinbeck K S Atkinson F S | 2010 | Am J Clin Nutr2010，92，1： | 1 |
| 11 | Synthesis of hydroxylated and methoxylated polybrominated diphenyl ethers natural products and potential polybrominated diphenyl ether metabolites显示文摘 | Marsh G Stenutz R Bergman A | 2003 | European Journal of Organic Chemistry2003，，： | 1 |
| 12 | Neuropsychiatric symptoms in Parkinson's disease显示文摘 | Aarsland D Marsh L Schrag A | 2009 | Mov Disord2009，24，15： | 1 |
| 13 | Impact of the fibrinolytic enzyme system on prognosis and survival associated with non- small cell lung carcinoma显示文摘 | Pavey S J Hawson G A Marsh N A | 2001 | Blood Coagul Fibrinolysis2001，12，1： | 1 |
| 14 | Effect of hot water treatments on chilling injury and heat damage in satsuma mandarins: Antioxidant enzymes and vacuolar ATPase, and pyrophosphatase显示文摘 | GHASEMNEZHAD M MARSH K SHILTON R BABALAR M WOOLF A | 2008 | Postharvest Biology and Technology2008，48，： | 1 |
| 15 | Room temperature ionic liquids and their mixtures-a review显示文摘 | Marsh K N Boxall J A Lichtenthaler R | 2004 | Fluid Phase Equilibria2004，219，： | 1 |
| 16 | Purification and charactcrization of clavaminate synthase from streptomyces clavuligetus:an unusual oxidative enzyme in natural product biosynthesis显示文摘 | Marsh E N Townsend C A | 1990 | Biochemistry1990，29，： | 1 |
| 17 | Aggressive school troublemakers and victims: a longitudinal model examining the pivotal role of self-concept 显示文摘 | Marsh HW Parada R H Yeung A S | 2001 | Journal of Educational Psychology2001，93，2： | 1 |
| 18 | New directions in the study of policy networks显示文摘 | R A W RHODES MARSH D | 1992 | European Journal of Political Research1992，21，1： | 1 |
| 19 | Hormones and growth in poutry显示文摘 | SCANES C G HARVEY S MARSH J A | 1984 | Poul Sci1984，63，： | 1 |
| 20 | Room temperature ionic liquids and their mixtures--a review显示文摘 | MARSH K N BOXALL J A LICHTENTHALER R | 2004 | Fluid Phase Equilibria2004，219，： | 1 |
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