|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 5 |
| 3 | A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2008 Update显示文摘 | Emmet B. Keeffe Douglas T. Dieterich Steven-Huy B. Han Ira M. Jacobson Paul Martin Eugene R. Schiff Hillel Tobias | 2008 | Clinical Gastroenterology and Hepatology2008，，12： | 5 |
| 4 | A comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma显示文摘AIM:To compare the clinical outcome and pathologic features of non-alcoholic steatohepatitis(NASH) patients with hepatocellular carcinoma(HCC) and hepatitic C virus(HCV) patients with HCC(another group in which HCC is commonly seen) undergoing liver transplantation.METHODS:Patients transplanted for HCV and NASH at our institution from January 2000 to April 2011 were analyzed.All explanted liver histology and pre-transplant liver biopsies were examined by two specialist liver histopathologists.Patient demographics,disease free survival,explant liver characteristics and HCC features(tumour number,cumulative tumour size,vascular invasion and differentiation) were compared between HCV and NASH liver transplant recipients.RESULTS:A total of 102 patients with NASH and 283 patients with HCV were transplanted.The incidence of HCC in NASH transplant recipients was 16.7%(17/102).The incidence of HCC in HCV transplant recipients was 22.6%(64/283).Patients with NASH-HCC were statistically older than HCV-HCC patients(P < 0.001).A significantly higher proportion of HCV-HCC patients had vascular invasion(23.4% vs 6.4%,P = 0.002) and poorly differentiated HCC(4.7% vs 0%,P < 0.001) compared to the NASH-HCC group.A trend of poorer recurrence free survival at 5 years was seen in HCV-HCC patients compared to NASH-HCC who underwent a Liver transplantation(P = 0.11).CONCLUSION:Patients transplanted for NASH-HCC appear to have less aggressive tumour features compared to those with HCV-HCC,which likely in part accounts for their improved recurrence free survival. | Roberto Hernandez-Alejandro Kris P Croome Martin Drage Nathalie Sela Jeremy Parfitt Natasha Chandok Paul Marotta Cheryl Dale William Wall Douglas Quan | 2012 | World Journal of Gastroenterology2012，18，31： | 5 |
| 5 | A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: An Update显示文摘 | Emmet B. Keeffe Douglas T. Dieterich Steven–Huy B. Han Ira M. Jacobson Paul Martin Eugene R. Schiff Hillel Tobias Teresa L. Wright | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 2 |
| 6 | A Predictive Model for Lymph Node Yield in Colon Cancer Resection Specimens显示文摘 | Garrett M. Nash David Row Alexander Weiss Jinru Shia Jose G. Guillem Philip B. Paty Mithat Gonen Martin R. Weiser Larissa K. Temple Garrett Fitzmaurice W. Douglas Wong | 2011 | Annals of Surgery2011，，2： | 2 |
| 7 | Sphincter Preservation in Low Rectal Cancer is Facilitated by Preoperative Chemoradiation and Intersphincteric Dissection显示文摘 | Martin R. Weiser Hak-Mien Quah Jinru Shia José G. Guillem Philip B. Paty Larissa K. Temple Karyn A. Goodman Bruce D. Minsky W Douglas Wong | 2009 | Annals of Surgery2009，，2： | 2 |
| 8 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Catherine S.M. Diefenbach Zharna Shah Alexia Iasonos Richard R. Barakat Douglas A. Levine Carol Aghajanian Paul Sabbatini Martee L. Hensley Jason Konner William Tew David Spriggs Martin Fleisher Howard Thaler Jakob Dupont | 2006 | Gynecologic Oncology2006，，： | 2 |
| 9 | Large-diameter biliary orifice balloon dilation to aid in endoscopic bile duct stone removal: a multicenter series显示文摘 | Siriboon Attasaranya Young Koog Cheon Harsha Vittal Douglas A. Howell Donald E. Wakelin John T. Cunningham Niraj Ajmere Ronald W. Ste Marie Kanishka Bhattacharya Kapil Gupta Martin L. Freeman Stuart Sherman Lee McHenry James L. Watkins Evan L. Fogel Suzet | 2008 | Gastrointestinal Endoscopy2008，，7： | 2 |
| 10 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 2 |
| 11 | Statistical Methods for AssessingAgreement between Two Methods of Clinical Measurement 显示文摘 | Martin Bland J Douglas G Altman | 2010 | In-ternational Journal of Nursing Studies2010，47，8： | 1 |
| 12 | The 50-Year History, Controversy, and Clinical Implications of Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy显示文摘 | Barry J. Maron Martin S. Maron E. Douglas Wigle Eugene Braunwald | 2009 | Journal of the American College of Cardiology2009，，3： | 1 |
| 13 | Squamous-Cell Carcinoma of the Rectum: A Rare but Curable Tumor显示文摘 | Caio S. R. Nahas M.D. Jinru Shia M.D. Romane Joseph M.D. Deborah Schrag M.D. Bruce D. Minsky M.D. Martin R. Weiser M.D. Jose G. Guillem M.D. Phillip B. Paty M.D. David S. Klimstra M.D. Laura H. Tang M.D. W. Douglas Wong M.D. Larissa K. Temple M.D | 2007 | Diseases of the Colon & Rectum2007，，9： | 1 |
| 14 | ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death显示文摘 | Douglas P. Zipes A. John Camm Martin Borggrefe Alfred E. Buxton Bernard Chaitman Martin Fromer Gabriel Gregoratos George Klein Arthur J. Moss Robert J. Myerburg Silvia G. Priori Miguel A. Quinones Dan M. Roden Michael J. Silka Cynthia Tracy Sidney C. Smit | 2006 | Journal of the American College of Cardiology2006，，5： | 1 |
| 15 | Compliance with CPAP therapy in patients with the sleep apnoea/hypopnoea syndrome显示文摘 | ENGLEMAN H M MARTIN S E DOUGLAS NJ | 1994 | Thorax1994，49，： | 1 |
| 16 | A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2008 Update显示文摘 | Emmet B. Keeffe Douglas T. Dieterich Steven-Huy B. Han Ira M. Jacobson Paul Martin Eugene R. Schiff Hillel Tobias | 2008 | Clinical Gastroenterology and Hepatology2008，，12： | 1 |
| 17 | The Appendix May Protect Against Clostridium difficile Recurrence显示文摘 | Gene Y. Im Rani J. Modayil Cheng T. Lin Steven J. Geier Douglas S. Katz Martin Feuerman James H. Grendell | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 1 |
| 18 | The Appendix May Protect Against Clostridium difficile Recurrence显示文摘 | Gene Y. Im Rani J. Modayil Cheng T. Lin Steven J. Geier Douglas S. Katz Martin Feuerman James H. Grendell | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 1 |
| 19 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 20 | An update on econometric studies of energy demand behavior显示文摘 | DOUGLAS R BOHI MARTIN B ZIMMERMAN | 1984 | Annual Review of Energy1984，9，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员