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| 1 | Biomaterials for spinal cord repair显示文摘Spinal cord injury (SCi) results in permanent loss of function leading to often devastating personal, economic and social problems. A contributing factor to the permanence of SCi is that damaged axons do not regenerate, which prevents the re-establishment of axonal circuits involved in function. Many groups are working to develop treatments that address the lack of axon regeneration after SCi. The emergence of biomaterials for regeneration and increased collaboration between engineers, basic and translational scientists, and clinicians hold promise for the development of effective therapies for SCi. A plethora of biomaterials is available and has been tested in various models of SCi. Considering the clinical relevance of contusion injuries, we primarily focus on polymers that meet the specific criteria for addressing this type of injury. Biomaterials may provide structural support and/or serve as a delivery vehicle for factors to arrest growth inhibition and promote axonal growth. Designing materials to address the specific needs of the damaged central nervous system is crucial and possible with current technology. Here, we review the most prominent materials, their optimal characteristics, and their potential roles in repairing and regenerating damaged axons following SCi. | Agnes E. Haggerty Martin oudega | 2013 | Neuroscience Bulletin2013，29，4： | 9 |
| 2 | Manipulation of SlMXl for enhanced carotenoids accumulation and drought resistance in tomato显示文摘Plants are the ultimate source of nutrients in the human diet. To ensure adequate availability of high quality food for an increasing world population, traits including improved tolerance of stresses and nutrient levels need to be selected in crops, both individually and in combination. Here we report the identification of Sl MX1 encoding a MIXTA-like MYB transcription factor in tomato that simultaneously modulates drought resistance and metabolic processes through regulating key structural and regulatory genes of the corresponding pathways. Over-expression of Sl MX1 results in substantially increased drought tolerance and improved fruit quality, while knocking down Sl MX1 resulted in the opposite phenotypes. Our study indicates an effective way with multiple beneficial traits by genetic engineering of a single regulatory gene and can be a novel approach to breeding crops. | Mohamed Ewas Yanqiang Gao Shouchuang Wang Xianqing Liu Hongyan Zhang Elsayed M. E. Nishawy Farhan Aii Raheel Shahzad Khurram Ziaf Hizar Subthain Cathie Martin Jie Luo | 2016 | Science Bulletin2016，61，18： | 9 |
| 3 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 5 |
| 4 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma显示文摘 | Andrew D. Rhim Paul E. Oberstein Dafydd H. Thomas Emily T. Mirek Carmine F. Palermo Stephen A. Sastra Erin N. Dekleva Tyler Saunders Claudia P. Becerra Ian W. Tattersall C. Benedikt Westphalen Jan Kitajewski Maite G. Fernandez-Barrena Martin E. Fernandez- | 2014 | Cancer Cell2014，，： | 5 |
| 5 | Energy and Water Optimization in Biofuel Plants显示文摘In this paper we address the topic of energy and water optimization in the production of bioethanol from corn and switchgrass. We show that in order for these manufacturing processes to be attractive,there is a need to go beyond traditional heat integration and water recycling techniques. Thus,we propose a strategy based on mathe-matical programming techniques to model and optimize the structure of the processes,and perform heat integration including the use of multi-effect distillation columns and integrated water networks to show that the energy effi-ciency and water consumption in bioethanol plants can be significantly improved. Specifically,under some circum-stances energy can even be produced and the water consumption can be reduced below the values required for the production of gasoline. | Ignacio E. Grossmann Mariano Martin | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 5 |
| 6 | 陶瓷球头和金属球头配伍聚乙烯臼杯的20年长期对比磨损研究显示文摘背景关节承载面是假体磨损过程中的重要假体相关因素。目前已知聚乙烯磨损是全髋关节置换术后髋臼和股骨假体组件无菌性松动的主要原因。方法本项前瞻性研究中,共随机挑选了80例同时期患者共93个髋关节接受了非骨水泥髋关节置换术,使用钛涂层的RM臼杯和CLS股骨柄。80例髋关节使用陶瓷球头,13例使用钴铬钼合金球头,所有股骨头直径均为32 mm。所有患者平均年龄为52岁,研究平均随访时间为19.3年。所有患者均获得随访。结果随访时使用EBRA系统对髋臼假体组件的磨损、倾斜和前倾角进行影像学评估。其中55例髋关节进行了磨损率的确认。翻修病例的平均磨损率为0.191 mm年/,而未翻修病例的平均磨损率为0.105 mm年/(P=0.041)。钴铬钼合金组平均磨损率为0.190 mm年/,陶瓷组平均磨损率为0.107 mm年/(P=0.025)。钴铬钼合金组的翻修率(13例中6例)明显高于陶瓷组(80例中11例)。股骨球头磨损率与其材料(P=0.025)、股骨柄周围骨溶解(P=0.003)、臼杯骨溶解(P=0.011)、臼杯翻修(P=0.041)以及臼杯倾斜(P=0.012)呈正性相关。结论本长期研究表明,在20年的时间里,陶瓷股骨头与钴铬钼合金股骨头相比造成的线性磨损更少,从而显著减少骨溶解的发生以及任一假体部件的翻修。 | Martin Ihle Sabine Mai Werner E. Siebert 张卓(译) 陈文(校) | 2010 | 中华关节外科杂志(电子版)2010，4，3： | 4 |
| 7 | Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration显示文摘 | Daniel F. Martin Maureen G. Maguire Stuart L. Fine Gui-shuang Ying Glenn J. Jaffe Juan E. Grunwald Cynthia Toth Maryann Redford Frederick L. Ferris | 2012 | Ophthalmology2012，，7： | 3 |
| 8 | Cardiometabolic Aspects of the Polycystic Ovary Syndrome显示文摘 | Harpal S. Randeva Bee K. Tan Martin O. Weickert Konstantinos Lois John E. Nestler Naveed Sattar Hendrik Lehnert | 2012 | Endocrine Reviews2012，，5： | 3 |
| 9 | Global Income Divergence, Trade, and Industrialization: The Geography of Growth Take-Offs显示文摘 | Richard E. Baldwin Philippe Martin Gianmarco I. P. Ottaviano | 2001 | Journal of Economic Growth2001，，1： | 3 |
| 10 | CYFRA 21-1 as a Prognostic and Predictive Marker in Advanced Non–Small-Cell Lung Cancer in a Prospective Trial: CALGB 150304显示文摘 | Martin J. Edelman Lydia Hodgson Paula Y. Rosenblatt Robert H. Christenson Everett E. Vokes Xiaofei Wang Robert Kratzke | 2012 | Journal of Thoracic Oncology2012，，4： | 3 |
| 11 | Developing Predictive Models of Health Literacy显示文摘 | Laurie T. Martin Teague Ruder José J. Escarce Bonnie Ghosh-Dastidar Daniel Sherman Marc Elliott Chloe E. Bird Allen Fremont Charles Gasper Arthur Culbert Nicole Lurie | 2009 | Journal of General Internal Medicine2009，，11： | 3 |
| 12 | Quality Improvement Guidelines for the Treatment of Lower Extremity Deep Vein Thrombosis with Use of Endovascular Thrombus Removal显示文摘 | Suresh Vedantham Patricia E. Thorpe John F. Cardella Clement J. Grassi Nilesh H. Patel Hector Ferral Lawrence V. Hofmann Bertrand M. Janne d’Othée Vittorio P. Antonaci Elias N. Brountzos Daniel B. Brown Louis G. Martin Alan H. Matsumoto Steven G. Meranze | 2006 | Journal of Vascular and Interventional Radiology2006，，3： | 3 |
| 13 | HEAT-SHOCK PROTEINS, MOLECULAR CHAPERONES, AND THE STRESS RESPONSE: Evolutionary and Ecological Physiology显示文摘 | Martin E. Feder Gretchen E. Hofmann | 1999 | Annual Review of Physiology1999，，： | 3 |
| 14 | Results of Ankle Fractures with Involvement of the Posterior Tibial Margin显示文摘 | Johan F. Langenhuijsen Martin J. Heetveld Jan M. Ultee E. Philip Steller Rudi M. J. M. Butzelaar | 2002 | The Journal of Trauma: Injury, Infection, and Critical Care2002，，1： | 3 |
| 15 | Volumetric parameterization and trivariate B-spline fitting using harmonic functions显示文摘 | T. Martin E. Cohen R.M. Kirby | 2008 | Computer Aided Geometric Design2008，，6： | 2 |
| 16 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 17 | TETRASPANIN PROTEINS MEDIATE CELLULAR PENETRATION, INVASION, AND FUSION EVENTS AND DEFINE A NOVEL TYPE OF MEMBRANE MICRODOMAIN显示文摘 | Martin E. Hemler | 2003 | Annual Review of Cell and Developmental Biology2003，，： | 2 |
| 18 | Pinoresinol–lariciresinol reductase gene expression and secoisolariciresinol diglucoside accumulation in developing flax ( Linum usitatissimum ) seeds显示文摘 | C. Hano I. Martin O. Fliniaux B. Legrand L. Gutierrez R. R. J. Arroo F. Mesnard F. Lamblin E. Lainé | 2006 | Planta2006，，6： | 2 |
| 19 | 18F-fluorodeoxyglucose positron emission tomography in management of pancreatic cystic tumors显示文摘 | Yaojun Zhang Adam E. Frampton Jack L. Martin Charis Kyriakides Jan Jin Bong Nagy A. Habib Panagiotis Vlavianos Long R. Jiao | 2012 | Nuclear Medicine and Biology2012，，7： | 2 |
| 20 | Global Income Divergence, Trade, and Industrialization: The Geography of Growth Take-Offs显示文摘 | Richard E. Baldwin Philippe Martin Gianmarco I. P. Ottaviano | | Journal of Economic Growth0，，： | 2 |
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