|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer显示文摘 | Florian R. Greten Lars Eckmann Tim F. Greten Jin Mo Park Zhi-Wei Li Laurence J. Egan Martin F. Kagnoff Michael Karin | 2004 | Cell2004，，3： | 4 |
| 3 | Characterization of Hepatitis C Virus Resistance from a Multiple-Dose Clinical Trial of the Novel NS5A Inhibitor GS-5885显示文摘 | Kelly A. Wong Angela Worth Ross Martin Evguenia Svarovskaia Diana M. Brainard Eric Lawitz Michael D. Miller Hongmei Mo | 2013 | Antimicrobial Agents and Chemotherapy2013，，12： | 2 |
| 4 | Lancet显示文摘 | Adam IJ Mohamdee MO Martin IG Role of circumferential margin involvement in the local recurrence of rectal cancer | 1994 | 334:701~7071994，334，： | 1 |
| 5 | Role of circumferential margin involvement in the local recurrence of rectal cancer显示文摘 | Adam IJ Mohamdee MO Martin IG | 1994 | Lancet1994，344，8924： | 1 |
| 6 | Impaired heart rate response to graded exercise CRI 显示文摘 | Michale SL Peter MO Martin GL | 1996 | Culation1996，93，3： | 1 |
| 7 | Gene expression and protein localization of TLR-1, -2, -4 and -6 in amniochorion membranes of pregnancies complicated by histologic chorioamnionitis显示文摘 | Natália P. Mo?o Laura F. Martin Ana Carolina Pereira Jossimara Polettini José C. Pera?oli Kunie I.R. Coelho Márcia G. da Silva | 2013 | European Journal of Obstetrics and Gynecology2013，，： | 1 |
| 8 | Acute fetalasphyxia and permanent brain injury:a retrospective analysis of cur-rent indicators显示文摘 | Korst LM Phelan JP Wang YM Martin GI Ahn MO | 1999 | J Matern Fetal Med1999，8，3： | 1 |
| 9 | The holy grail of science policy:exploring and combining bibliometric tools in search of scientific excellence显示文摘 | THED N VANLEEUWEN MARTIN S VISSER HENK F MOED TON J NEDERHOF ANTHONY F J VANRAAN | 2003 | Scientometrics2003，，2： | 1 |
| 10 | Role of circumferential margin involvement in the local recurrence of rectal cancer显示文摘 | Adam I J Mohamdee MO Martin IG | 1994 | Lancet1994，344，： | 1 |
| 11 | Role of circumferential margin involvement in the local recurrence of rectal cancer显示文摘 | Adam IJ Mohamdee MO Martin IG | | The Lancet0，，： | 1 |
| 12 | Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance显示文摘 | Powdrill M H Tchesnokov E P Kozak R A Russell R S Martin R Svarovskaia E S Mo H Kouyos R D Gtte M | 2011 | Proc Natl Acad Sci U S A2011，108，20： | 1 |
| 13 | Role of circumferential margin involvement in the local recurrence of rectal cancer显示文摘 | Adam I J Mohamdee MO Martin IG | 1994 | Lancet1994，344，8924： | 1 |
| 14 | Predictors of mortality in HIV-associated hospitalizations in Portugal: a hierarchical survival model显示文摘 | Dias SS Andreozzi V Martins MO | 2009 | BMC Health Serv Res2009，9，： | 1 |
| 15 | Role of circumferential margin involvement in the local recurrence of rectal cancer 显示文摘 | Adam IJ Mohamdee MO Martin IG | 1994 | Lancet1994，344，8924： | 1 |
| 16 | Role of circumferential margin involvement in the local recurrence of rectal cancer 显示文摘 | Mohamdee MO Martin IG | 1994 | Lancet1994，344，： | 1 |
| 17 | Activity of Pemetrexed (ALIMTA?, Multitargeted Antifolate, LY231514) in Metastatic Breast Cancer Patients Previously Treated with an Anthracycline and a Taxane: An Interim Analysis显示文摘 | Marc Spielmann Miguel Martin Mo?se Namer Andreas duBois Clemens Unger David J. Dodwell | 2001 | Clinical Breast Cancer2001，，1： | 1 |
| 18 | Role of circumferentialmargin involvement in the local recurrence of rectal cancer 显示文摘 | Adam IJ Mohamdee MO Martin IG | 1994 | Lancet1994，344，8924： | 1 |
| 19 | Impaired heart rate response to graded exercise 显示文摘 | Michael SL Peter MO Martin GL | 1996 | Circulation1996，93，： | 1 |
| 20 | Electrical and rheological percolation in poly(vinylidene fluoride)/multi-walled carbon nanotube nanocomposites显示文摘 | Johnny N Martins Taís S Bassani Guilherme MO Barra | 2011 | Polymer International2011，60，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员