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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | 高危患者目标血压与心血管病预后显示文摘指南推荐血压目标值应〈140/90 mmHg(1mmHg=0.133kPa)以减少心血管事件的发生。但与其他心血管病预后(如冠状动脉事件)相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件(如冠状动脉事件)风险在收缩压低时亦增高,风险-收缩压关系呈J形曲线,而脑卒中与血压不是J形曲线关系。 | B?hm M Schumacher H Teo KK Lonn EM Mahfoud F Mann JF Mancia G Redon J Schmieder RE Sliwa K Weber MA Williams BYusuf S 曲浥晨 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 14 |
| 3 | Sonographic appearance of anal cushions of hemorrhoids显示文摘AIM To evaluate the diagnostic value of different sonographic methods in hemorrhoids.METHODSForty-two healthy volunteers and sixty-two patients with gradesⅠ-Ⅳhemorrhoids received two different sonographic examinations from January 2013 to January2016 at the First and Second Hospitals of Xinjiang Medical University in a prospective way.We analyzed the ultrasonographic findings of these participants and evaluated the outcomes.Resected gradesⅢandⅣhemorrhoid tissues were pathologically examined.The concordance of ultrasonographic results with pathologyresults was assessed with the Cohen’s kappa coefficient.RESULTS All healthy volunteers and all patients had no particular complications related to sonography.There were no statistically significant differences between the participants regarding age(P=0.5919),gender(P=0.4183),and persistent symptoms(P>0.8692).All healthy control participants had nospecial findings.However,30 patients with hemorrhoids showed blood signals around the dentate line on ultrasonography.When gradesⅠandⅡhemorrhoids were analyzed,there were no significant differences between transrectal ultrasound(TRUS),transperianal ultrasound(TPUS),and transvaginal ultrasound(TVUS)(P>0.05).GradesⅢandⅣhemorrhoids revealed blood flow with different directions which could be observed as a'mosaic pattern'.In patients with gradesⅢandⅣhemorrhoids,the number of patients with'mosaic pattern'as revealed by TRUS,TPUS and TVUS was 22,12,and 4,respectively.Patients with gradesⅢandⅣdisease presented with a pathologically abnormal cushion which usually appeared as a'mosaic pattern'in TPUS and an arteriovenous fistula in pathology.Subepithelial vessels of resected gradesⅢandⅣhemorrhoid tissues were manifested by obvious structural impairment and retrograde and ruptured changes of internal elastic lamina.Some parts of the Trietz’s muscle showed hypertrophy and distortion.Arteriovenous fistulas and venous dilatation were obvious in the anal cushion of hemorhoidal tissues.After pathological results with arteriovenous fistulas were taken as the standard reference,we evaluated the compatibility between the two methods according to the Cohen’s kappa coefficiency calculation.The compatibility(Cohein kappa co-efficiency value)between'mosaic pattern'in the TPUS and arteriovenous fistula in pathology was very good(?=0.8939).When compared between different groups,TRUS presented the advantage that the mosaic pattern could be confirmed in more patients,especially for group A.There was a statistical difference when comparing group A with group B or C(P<0.05 for both).There were obvious statistical differences between group A and group B with regard to the vessel diameter and blood flow velocity measured by TRUS(P<0.05).CONCLUSION Patients with gradesⅢandⅣhemorrhoids present with a pathologically abnormal cushion which usually appears as a'mosaic pattern'in sonography,which is in accord with an arteriovenous fistula in pathology.There are clearly different hemorrhoid structures shown by sonography.'Mosaic pattern'may be a parameter for surgical indication of gradesⅢandⅣhemorrhoids. | Adilijiang Aimaiti Ma Mu Ti Jiang A Ba Bai Ke Re Irshat Ibrahim Hui Chen Maimaitituerxun Tuerdi Mayinuer | 2017 | World Journal of Gastroenterology2017，23，20： | 11 |
| 4 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 5 | Polymorphism in the upstream regulatory region of human papilloma virus type 16 from the cervical cancer biopsies in Xinjiang Uygur women显示文摘To investigate the mutations in the upstream regulatory region (URR) of human papillomavirus type 16 (HPV-16) from the cervical cancer biopsies in Xinjiang Uygur women and its relationship to the high incidence of cervical cancer in the southern Xinjiang, the tissue DNA was extracted from the cervical cancer biopsies, and the URR segment of HPV-16 DNA was amplified, sequenced and analyzed. Thereafter, the polymorphism of URR in HPV-16 was then analyzed. It was demonstrated that the positive rate detected for the presence of URR in HPV-16 was 89.47% (17/19). Compared with the previously published sequence in URR of prototype HPV-16, some mutations were detected in the sequence of URR. The mutations in 17 URR fragments of HPV-16 could be divided into 11 patterns (XJU-1 to XJU-11) at nucleic acid level, in which each of XJU-1 and XJU-4 accounted for 23.53% (4/17), and other patterns of mutation accounted for 5.88% (1/17) . In comparison with the URR of prototype HPV-16, the DNA identity of these patterns was 98.50%-99.68% . In these 17 URR fragments, two point mutations occurred at position 7192 (G to T) and position 7520 (G to A) and they appeared to be constant in Xinjiang area. These two mutations were ubiquitous in the Asia-American type and conferred strong infection activity and carcinogenicity of this virus. In addition, the mutations at position 7729 (A to C), position 7843 (A to G) and position 7792 (C to T) could enhance its transcription activity considerably. It is concluded that some mutations occur in URR gene of HPV-16 in the cervical cancer biopsies taken from Uygur women in Xinjiang area, suggesting that certain relationship exists among the mutations in URR of HPV-16, the phylogeny of HPV-16 and the high incidence of cervical cancer in southern part of Xinjiang area. | MENG YU ZHENG HAI MA YAN PIN WANG XI DAN RE FU CHUN ZHANG | 2006 | Journal of Microbiology and Immunology2006，4，3： | 4 |
| 6 | Aberrant unclear factor-K appaB/Rel expression and the pathogenesis of breast cancer 显示文摘 | Sovak MA Bellas RE Kim DW | 1997 | Clin Invest1997，100，12： | 1 |
| 7 | An obesity-associated gut microbiome with increased capacity for energy harvest 显示文摘 | Turnbaugh PJ Ley RE Mahowald MA | 2006 | Nature2006，444，： | 1 |
| 8 | DeoxyArbutin:a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency显示文摘 | Boissy RE Visscher M DeLong MA | 2005 | Exp Dermatol2005，14，8： | 1 |
| 9 | Immunomodulation of vascular endothelium显示文摘 | Martin ML Contort RE Hordy MA | 1990 | Jsurg Res1990，48，： | 1 |
| 10 | Atraumatic osteonecrosis of the talus 显示文摘 | Delanois RE Mont MA Yoon TR | 1998 | J Bone Joint Surg Am1998，80，4： | 1 |
| 11 | Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4显示文摘 | Wendt MA Mercurio AM | 2002 | Cancer Res2002，62，24： | 1 |
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| 13 | Advances in Gastrointesti nal Intervention:The Treatment of Gastroduodenal and Colorectal Obstructions with Metallic Stents显示文摘 | Mauro MA Koehler RE Baron TH | 2000 | Radiology2000，215，3： | 1 |
| 14 | The potential use of laser cap-ture microdissection to selectively obtain distinct populations of cells for proteomic analysis-preliminary findings显示文摘 | Banks RE Dunn MJ Forbe MA | 1999 | From genome to pro-teome1999，20，1： | 1 |
| 15 | Successful use of anti-CD20(rituximab)in severe,life-threatening childhood immune thrombocytopenic purpura显示文摘 | Bengtson KL Skinner MA Ware RE | 2003 | J Pediatr2003，143，5： | 1 |
| 16 | Molecular and cellular mechanisms of lymphangiogenesis 显示文摘 | J AI Rawi MA Mansel RE Jiang WG | 2005 | Euro J Surg Oncol2005，31，2： | 1 |
| 17 | Vascular endothelial growth factor promotes carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4显示文摘 | Bachelder RE Wendt MA Mercurio Am | 2002 | Cancer Res2002，62，24： | 1 |
| 18 | The Management of lower gastrointestinal hemorrhage 显示文摘 | Hoedema RE Luchtefeld MA | 2005 | Dis Colon Rectum2005，48，11： | 1 |
| 19 | Treatment of severe complicated Kawasaki desease with oral prednisolone and aspirin显示文摘 | Dale Re Saleem MA Daw S | 2000 | J Peiatr2000，137，： | 1 |
| 20 | Disparities in ova- dan cancer care quality and survival according to race and socioeconomic status显示文摘 | Bristow RE PoweU MA AI-Hammadi N | 2013 | d Natl Cancer lnst2013，105，11： | 1 |
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