|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 2 | A study of liquid metal atomization us- ing close-coupled nozzles, part 2: atomization behavior显示文摘 | Mates S P Settles G S | 2005 | At- omization and Sprays2005，15，1： | 1 |
| 3 | A study of liquid metal atomization using close-coupled nozzles, part 1: Gas dynamic behavior 显示文摘 | MATES S P SETTLES G S | 2005 | Atomization and Sprays2005，15，： | 1 |
| 4 | A study of liquid metal atomization using close-coupled nozzles, part 2: Atomization behavior 显示文摘 | MATES S P SETTLES G S | 2005 | Atomization and Sprays2005，15，： | 1 |
| 5 | Aromic-scale friction of a tungsten tip on a graphite surface 显示文摘 | C M Mate G M McClelland R Erlandsson and S Chiang | 1942 | Physic Rev Lett1942，59，17： | 1 |
| 6 | Lumped model for aerial blast wave propagation and structure interaction显示文摘 | Mate Saraiva J G | 1991 | Computational Mechanics1991，，： | 1 |
| 7 | Decentralizedcontrol for parallel operation of distributed generation invertersusing resistive output impedance 显示文摘 | GUERRERO J M MATES J VICUNA L G D | 2007 | IEEE Transactions onIndustrial Electronics2007，54，2： | 1 |
| 8 | Features of Krukenberg-type tumors--clinical study and review显示文摘 | Mates I N C Iosif G Banceanu | | 0，，： | 1 |
| 9 | Low-dose aspirin and prevention of cranial ischemic complications in giant cell arteritis 显示文摘 | NESHER G BERKUN Y MATES M | 2004 | Arthritis Rheum2004，50，4： | 1 |
| 10 | A first insight into the genetic diversity of Mycobacterium tuberculosisisolates in Dar es Salaam,Tanzaia,assessed by Spoligotyping显示文摘 | Eldholm V Matee M Mfinange S G | 2006 | BMC Microbiol2006，6，： | 1 |
| 11 | Atomic-scale friction of a tungsten tip on a graphite surface显示文摘 | Mate C M McClelland G M Erlandsson R | 1987 | Physical Re- view Letters1987，59，17： | 1 |
| 12 | Glutathione and its relationship with intracel-lular redox status,oxidative stressand cell proliferation/death 显示文摘 | Mates J M Pe R G Mez Z C | 2002 | The International Journal of Biochemistry & Cell Biology2002，34，： | 1 |
| 13 | A study of liquid metal atomization using close-coupled nozzles, Part 1: Gas dynamic behavior 显示文摘 | MATES S P SETTLES G S | 2005 | Atomization and Sprays2005，15，1： | 1 |
| 14 | Atomic-scale friction of a tungsten tip on a graphite surface显示文摘 | Mate C M Mcclelland G M Erlandsson R Chiang S | 1987 | Physical Review Letters1987，59，17： | 1 |
| 15 | Atomicscale friction of a tungsten tip on a graphite surface显示文摘 | Mcclelland G M Erlandsson R | 1987 | Physical Review Letters1987，59，17： | 1 |
| 16 | Atomic scale friction between the muscovite mica cleavage plane and a tungsten tip显示文摘 | Hadziioannou G Mate C M | 1988 | Journal of Chemical Physics1988，89，8： | 1 |
| 17 | Thyroid fine-needle aspiration samples inadequate for reverse transcriptase- polymerase chain reaction analysis显示文摘 | Samija I Mate g a N Lukac J | 2008 | Cancer Cy- topathology2008，114，3： | 1 |
| 18 | Atomic-scale Friction of a Tungsten Tip on a Graphite Sur-face显示文摘 | MATE G M MCCLELLAND G M EHLANDSSON R | 1987 | Physical Review Letters1987，59，： | 1 |
| 19 | A Study of Liquid Metal Atomization Using Close-Coupled Nozzles,Part 1:Gas Dynamic Behavior显示文摘 | Mates S P Settles G S | | 0，，01： | 1 |
| 20 | A Study of Liquid Metal Atomization Using Close-Coupled Nozzles,Part 2:Atomization Behavior显示文摘 | Mates S P Settles G S | | 0，，01： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员