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| 1 | Efficacy and safety of vildagliptin in clinical practice-results of the PROVIL-study显示文摘AIM:To investigate efficacy and safety of vildagliptin compared to other oral antidiabetics in clinical practice in Germany.METHODS:In this prospective,open,observational study,patients with type 2 diabetes mellitus(T2DM) previously on oral monotherapy were selected by their treating physician to receive either vildagliptin addon to metformin(cohort 1),vildagliptin+metformin single-pill combination(SPC)(cohort 2)or another dual combination therapy with oral antidiabetic drugs(OADs)(cohort 3).According to routine clinical practice,interim examinations occurred every 3 mo:at baseline,after approximately 3 mo and after approximately 6 mo.Parameters documented in the study included demographic and diagnostic data,history of T2DM,data on diabetes control,vital signs,relevant prior and concomitant medication and disease history.Efficacy was assessed by changes in HbA1c and fasting plasma glucose(FPG)3 mo and 6 mo after initiation of dual combination therapy.Safety was assessed by adverseevent reporting and measurement of specific laboratory values(serum creatinine,total bilirubin,alanine aminotransferase,aspartate aminotransferase,creatine kinase).RESULTS:Between October 2009 and January 2011,a total of 3881 patients were enrolled in this study.Since 47 patients were withdrawn due to protocol violations,3834 patients were included in the statistical analysis.There were no relevant differences between the three cohorts concerning age,body weight and body mass index.Average diabetes duration was approximately 6 years and mean HbA1c was between 7.6%and 7.9% at baseline.Antidiabetic treatment was recorded in 3648 patients.Patients were treated with vildagliptin add-on to metformin(n=603),vildagliptin+metformin(SPC)(n =2198),and other oral OADs including combinations of metformin with sulfonylurea(n=370),with glitazones(n =123),other dipeptidyl peptidase-4 inhibitors(n=99).After 6 mo of treatment,the absolute decrease in HbA1c(mean±SE)was significantly more pronounced in patients receiving vildagliptin add-on to metformin(-0.9% ±0.04%)and vildagliptin+metformin(SPC)(-0.9%± 0.03%)than in patients receiving other OADs(-0.6% ±0.04%;P<0.0001).In addition,significant cohort differences were observed for the improvement in FPG after 6 mo treatment(vildagliptin add-on to metformin:-291 mg/L±18.3 mg/L;vildagliptin+metformin(SPC):-305 mg/L±9.6 mg/L;other antidiabetic drugs:-209 mg/L±14.0 mg/L for(P<0.0001).Moderate decreases in body weight(absolute difference between last control and baseline:mean±SE)were observed for patients in all cohorts(vildagliptin add-on to metformin:-1.4 kg ±0.17 kg;vildagliptin+metformin(SPC):-1.7 kg± 0.09 kg;other OADs:?0.8 kg±0.13 kg).No significant differences in adverse events(AEs)and other safety measures were observed between the cohorts.When performing an additional analysis by age(patients<65 years vs patients≥65 years),there was no relevant difference in the most common AEs between the two age groups and the AE profile was similar to that of the overall patient population.CONCLUSION:Clinical practice confirms that vildagliptin is an effective and well-tolerated treatment in combination with metformin in T2DM patients. | Matthias Blüher Ira Kurz Simone Dannenmaier Markus Dworak | 2012 | World Journal of Diabetes2012，3，9： | 9 |
| 2 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 3 | California Simulation of Evapotranspiration of Applied Water and Agricultural Energy Use in California显示文摘The California Simulation of Evapotranspiration of Applied Water (Cal-SIMETAW) model is a new tool developed by the California Department of Water Resources and the University of California, Davis to perform daily soil water balance and determine crop evapotranspiration (ET c ), evapotranspiration of applied water (ET aw ), and applied water (AW) for use in California water resources planning. ET aw is a seasonal estimate of the water needed to irrigate a crop assuming 100% irrigation efficiency. The model accounts for soils, crop coefficients, rooting depths, seepage, etc. that influence crop water balance. It provides spatial soil and climate information and it uses historical crop and land-use category information to provide seasonal water balance estimates by combinations of detailed analysis unit and county (DAU/County) over California. The result is a large data base of ET c and ET aw that will be used to update information in the new California Water Plan (CWP). The application uses the daily climate data, i.e., maximum (T x ) and minimum (T n ) temperature and precipitation (P cp ), which were derived from monthly USDA-NRCS PRISM data (PRISM Group 2011) and daily US National Climate Data Center (NCDC) climate station data to cover California on a 4 km×4 km change grid spacing. The application uses daily weather data to determine reference evapotranspiration (ET o ), using the Hargreaves-Samani (HS) equation (Hargreaves and Samani 1982, 1985). Because the HS equation is based on temperature only, ET o from the HS equation were compared with CIMIS ET o at the same locations using available CIMIS data to determine correction factors to estimate CIMIS ET o from the HS ET o to account for spatial climate differences. Cal-SIMETAW also employs near real-time reference evapotranspiration (ET o ) information from Spatial CIMIS, which is a model that combines weather station data and remote sensing to provide a grid of ET o information. A second database containing the available soil water holding capacity and soil depth information for all of California was also developed from the USDA-NRCS SSURGO database. The Cal-SIMETAW program also has the ability to generate daily weather data from monthly mean values for use in studying climate change scenarios and their possible impacts on water demand in the state. The key objective of this project is to improve the accuracy of water use estimates for the California Water Plan (CWP), which provides a comprehensive report on water supply, demand, and management in California. In this paper, we will discuss the model and how it determines ET aw for use in water resources planning. | Morteza N Orang Richard L Snyder Shu Geng Quinn J Hart Sara Sarreshteh Matthias Falk Dylan Beaudette Scott Hayes Simon Eching | 2013 | Journal of Integrative Agriculture2013，12，8： | 3 |
| 4 | Comparison of cauliflower-insect-fungus interactions and pesticides for cabbage root fly control显示文摘 | Jaka Razinger Metka Zerjav Meta Zemljic-Urbancic Spela Modic Matthias Lutz Hans-Josef Schroers Jurg Grunder Simon Fellous Gregor Urek | 2017 | Insect Science2017，24，6： | 2 |
| 5 | Information asymmetry and the value of cash显示文摘 | Wolfgang Drobetz Matthias C. Grüninger Simone Hirschvogl | 2010 | Journal of Banking and Finance2010，，9： | 2 |
| 6 | Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia显示文摘 | Anya Pedersen Markus Diedrich Florian Kaestner Katja Koelkebeck Patricia Ohrmann Gerald Ponath Frank Kipp Simone Abel Ansgar Siegmund Thomas Suslow Christof von Eiff Volker Arolt Matthias Rothermundt | 2008 | Progress in Neuropsychopharmacology & Biological Psychiatry2008，，： | 1 |
| 7 | Engineering of Distributed Control Systems显示文摘 | Christian Diedrich Rene Simon Matthias Riedl | 2000 | Advanced Robotics2000，2，11： | 1 |
| 8 | Automatic land cover analysis for Tenerife by supervised classification using remotely sensed data显示文摘 | K Jens M Simone H Matthias | 2003 | Remote Sensing of Environment2003，86，： | 1 |
| 9 | Insular gliomas:the case for surgical managementClinical article显示文摘 | Matthias Simon M D | | 0，，： | 1 |
| 10 | Identification of a functional protein kinase Cβ promoter polymorphism in humans related to insulin resistance显示文摘 | Martin A. Osterhoff Susanne Heuer Michaela Pfeiffer Jelena Tasic Simone Kaiser Frank Isken Joachim Spranger Martin O. Weickert Matthias M?hlig Andreas F.H. Pfeiffer | 2007 | Molecular Genetics and Metabolism2007，，2： | 1 |
| 11 | Predictive impact of MGMT promoter methylation in glioblastoma of the elderly显示文摘 | Guido Reifenberger Bettina Hentschel J?rg Felsberg Gabriele Schackert Matthias Simon Oliver Schnell Manfred Westphal Wolfgang Wick Torsten Pietsch Markus Loeffler Michael Weller | 2012 | Int J Cancer2012，，6： | 1 |
| 12 | Trustworthy software systems显示文摘 | Steffen Becker Wilhelm Hasselbring Alexandra Paul Marko Boskovic Heiko Koziolek Jan Ploski Abhishek Dhama Henrik Lipskoch Matthias Rohr Daniel Winteler Simon Giesecke Roland Meyer Mani Swaminathan Jens Happe Margarete Muhle Timo Warns | 2006 | ACM SIGSOFT Software Engineering Notes2006，，6： | 1 |
| 13 | To Band or Not to Band—Early Results of Banded Sleeve Gastrectomy显示文摘 | W. Konrad Karcz Iwona Karcz-Socha Goran Marjanovic Simon Kuesters Matthias Goos Ulrich T. Hopt Tomasz Szewczyk Tobias Baumann Jodok Matthias Grueneberger | 2014 | Obesity Surgery2014，，4： | 1 |
| 14 | Does Rust Infection of Willow Affect Feeding and Oviposition Behavior of Willow Leaf Beetles显示文摘 | Matthias Simon Monika Hilker | | 0，，： | 1 |
| 15 | Joining by forming—A review on joint mechanisms, applications and future trends显示文摘 | Peter Groche Simon Wohletz Matthias Brenneis Christian Pabst Franziska Resch | 2013 | Journal of Materials Processing Tech2013，，： | 1 |
| 16 | Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette显示文摘 | Matthias Leisegang Boris Engels Peter Meyerhuber Elisa Kieback Daniel Sommermeyer Shao-An Xue Simone Reu? Hans Stauss Wolfgang Uckert | 2008 | Journal of Molecular Medicine2008，，5： | 1 |
| 17 | Trustworthy software systems显示文摘 | Steffen Becker Wilhelm Hasselbring Alexandra Paul Marko Boskovic Heiko Koziolek Jan Ploski Abhishek Dhama Henrik Lipskoch Matthias Rohr Daniel Winteler Simon Giesecke Roland Meyer Mani Swaminathan Jens Happe Margarete Muhle Timo Warns | 2006 | ACM SIGSOFT Software Engineering Notes2006，，6： | 1 |
| 18 | The Influence of Botulinum Toxin A Injections into the Calf Muscles on Genu Recurvatum in Children With Cerebral Palsy显示文摘 | Matthias C. M. Klotz Sebastian I. Wolf Daniel Heitzmann Simone Gantz Frank Braatz Thomas Dreher | 2013 | Clinical Orthopaedics and Related Research?2013，，： | 1 |
| 19 | Interactive blood simulation for virtual surgery based on smuuthed particle hydrodynamics 显示文摘 | Matthias Muller Simon Schinn Matthias Tesclmer | 2004 | Technology and Health Care2004，12，1： | 1 |
| 20 | Inhibition of VCAM-1 expression in endothelial cells by CORM-3: The role of the ubiquitin–proteasome system, p38, and mitochondrial respiration显示文摘 | Claudia Bergstraesser Simone Hoeger Hui Song Linda Ermantraut Maxi Hottenrot Tobias Czymai Marc Schmidt Matthias Goebeler Norbert Ponelies Carsten Stich Ralf Loesel Grietje Molema Marc Seelen Willem van Son Benito A. Yard Neysan Rafat | 2011 | Free Radical Biology and Medicine2011，，4： | 1 |
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