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| 1 | Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis显示文摘AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and ascites.METHODS An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of infection.RESULTS Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not significantly different in users or non-users of PPIs in this cohort of cirrhotic with ascites. | Suelen A S Miozzo Jorge A John Marcelo C Appel-da-Silva Isabella A Dossin Cristiane V Tovo Angelo A Mattos | 2017 | World Journal of Hepatology2017，9，35： | 5 |
| 2 | The use of primary stenting or balloon percutaneous tranluminal coronary angioplasty for the treatment of acutely occluded saphenous vein grafts, results from the brazilian national registry- CENIC 显示文摘 | Mattos L A Sousa AGMR Moura Campos Neto C | 2002 | Arq Bras Cardiol2002，76，： | 1 |
| 3 | Steady-state modeling of slurry and bulk propylene polymerizations显示文摘 | Mattos Neto A G Pinto J C | 2001 | Chemical Engineering Science2001，56，13： | 1 |
| 4 | Toxoplasma gondii isolates: muhilocus RFLP-PCR genotyping from human patients in Sao Paulo State, Brazil identified distinct genotypes显示文摘 | Ferreira IM Vidal JE de Mattos Cde C | 2011 | Exp Parasitol2011，129，2： | 1 |
| 5 | Zn-Ni and Zn-Fe alloy deposits modified by P incorporation properties 显示文摘 | ORD1NE AP DIAZ S L MARGARIT l C P MATTOS O R | 2004 | Electroehim Acta2004，49，： | 1 |
| 6 | Relaxing standard hedging assumptions in the presence of downside risk显示文摘 | Mattos F P Garcia P Nelson C | 2008 | Quarterly Review of Economics of Finance2008，48，1： | 1 |
| 7 | Performance of rust converter based in phosphoric and tannic acids显示文摘 | Ocampo L M Margarit I C P Mattos O R | 2004 | Corrosion Science2004，46，6： | 1 |
| 8 | Surface-mediated hydrohalogenation of isoprene: a facile preparation of prenyl halides显示文摘 | de Mattos M C S Sanseverino A M | 2003 | Synthetic Communications2003，33，13： | 1 |
| 9 | A nonlinear transmission line model of the lightning return stroke显示文摘 | Andre M Mattos F Christopoulos C | 1988 | IEEE Trans EMC1988，30，3： | 1 |
| 10 | A spatio-temporal approach for global validation and analysis of MODIS aerosol products 显示文摘 | Ichoku C Chu D A Matto S | 2002 | Geophys Res Lett2002，29，12： | 1 |
| 11 | 显示文摘 | Pinto J C | 2001 | Chem Eng Sci2001，56，13： | 1 |
| 12 | Magnetron sputtered SiC coatings as corrosion protection barriers for steels 显示文摘 | ORDINE A ACHETE C A MATTOS O R | 2000 | Surface and Coatings Technology2000，，11： | 1 |
| 13 | Tri-chloroi80cyanuric acid: An alternate green route for thetransformation of alkenes into epoxides 显示文摘 | Wengert M Sanseverino A M D Mattos M C S | 2002 | J BrazChem Soc2002，13，5： | 1 |
| 14 | Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors显示文摘 | Mattos C Giammona D A Petsko G A Ringe D | | 0，，10： | 1 |
| 15 | Electro Chemical Characterization of Chromate Coatings on Galvanized Steel显示文摘 | Magalh es A A O Margarit I C P Mattos O R | 1999 | Electrochimica Acta1999，44，24： | 1 |
| 16 | Relaxing standard hedging assumptions in the presence of downside risk显示文摘 | Mattos F Gareia P Nelson C | 2008 | Quarterly Review of Economics and Finance2008，48，1： | 1 |
| 17 | Steady-state modeling of slurry and bulk propylene polymerizations显示文摘 | MATTOS A G PINTO J C | 2001 | Chemical Engineering Science2001，56，13： | 1 |
| 18 | Myonuclei and satellite cells in denervated rat muscles: An electron microscopy study显示文摘 | de Castro R A Andreo J C de Mattos Rodrigues S P | 2006 | Microsurgery2006，26，5： | 1 |
| 19 | Toxoplasma gon- dii isolates : muhilocus RFLP-PCR genotyping from human patients in Sao Paulo State, Brazil identified distinct genotypes 显示文摘 | Ferreira I M Vidal J E de Mattos Cde C | 2011 | Exp Parasitol2011，129，2： | 1 |
| 20 | Ostreopsis ovata blooms on Rio de Janeiro coast 显示文摘 | Mattos Nascimento S Oliveira Monteiro P Leite Ferreira C E | 2008 | Harmful Algae News2008，37，： | 1 |
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