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| 1 | Cell Death Mechanisms Induced by Cytotoxic Lymphocytes显示文摘One of the functions of the immune system is to recognize and destroy abnormal or infected cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is a highly organized multifactor process. Here,we reviewed the apoptosis pathways induced by the two main cytotoxic lymphocyte subsets,natural killer(NK) cells and CD8+ T cells. In base to recent experimental evidence,we reviewed NK receptors involved in recognition of target-cell,as well as lytic molecules such as perforin,granzymes-A and-B,and granulysin. In addition,we reviewed the Fas-FasL intercellular linkage mediated pathway,and briefly the cross-linking of tumor necrosis factor(TNF) and TNF receptor pathway. We discussed three models of possible molecular interaction between lytic molecules from effector cytotoxic cells and target-cell membrane to induction of apoptosis. | Chávez-Galán L Arenas-Del Angel MC Zenteno E Chávez R Lascurain R | 2009 | Cellular & Molecular Immunology2009，6，1： | 17 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 4 | Thermal stability of SiC fibers (Nicalon) 显示文摘 | MAH T HECHT N L CULLUM D E Mc | 1984 | J Mater Sci1984，19，4： | 2 |
| 5 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | Osteoarthritis:epidemiology显示文摘 | Arden N Nevitt MC | 2006 | Best Pract Res Clin Rheumatol2006，20，1： | 1 |
| 8 | Chronic fatiguesyndrome:exercise performance related to immune dys-function显示文摘 | Nijs J Meeus M Mc Gregor N R | 2005 | Med Sci Sports Exerc2005，37，10： | 1 |
| 9 | Effect of adsorbents coated with titanium dioxide on the photocatalytic degradation of propoxur 显示文摘 | Lu MC Chen J N Chang K T etal | 1999 | Chemosphere1999，38，： | 1 |
| 10 | Prevalence of Cardiovasicular manifestations In Marfan syndrom显示文摘 | Porciani MC Attanasio N Lepri V | 2004 | Heart J suppl2004，5，8： | 1 |
| 11 | Diabetic gastroparesis in associstion with autonomic neuropathy and microvaxct nauropathy opathy显示文摘 | Kockar MC Kayahan IK Bavbek N | 2002 | Acta Med Okayama2002，56，5： | 1 |
| 12 | The role of ultrasound in renal insufficiency: the essentials显示文摘 | Khati N J Hill MC Kimmel PL | 2005 | Ultrasound Q2005，21，4： | 1 |
| 13 | Influence of arbuscular mycorrhizae and rehizobium on free polyamines and proline levels in water-stress alfalia显示文摘 | GOICOECHEA N SZAI AI G ANTOLIN MC SANCHEZ-DIAZ M PALDI E | 1998 | Journal of Plant Physiology1998，153，： | 1 |
| 14 | Maternal exposure to air pollutionbefore and during pregnancy related to changes in newborn's cordblood lymphocyte subpopulations显示文摘 | Baz N Slama R BénéMC | 2011 | BMC Pregnancy Childbirth2011，11，1： | 1 |
| 15 | Chronic apoptosis of vascular smooth cells accelerates atherosclerosis and promotes ca;cifi cation and medial degeneration显示文摘 | Clarke MC Littlewood TD Figg N | 2008 | Circ Res2008，102，12： | 1 |
| 16 | Late outcomes for aortic valve replacement with the CarpentierEdwards pericardial bioprosthesis:up to 17-year followup in 1,000 patients显示文摘 | Mc Clure RS Narayanasamy N Wiegerinck E | 2010 | Ann Thorac Surg2010，89，5： | 1 |
| 17 | Forces between surfaces in liquids显示文摘 | Israelachvili J N Mc Guiggan P M | 1988 | Science1988，241，： | 1 |
| 18 | Magnetic resonance imaging of the lumbar spine in people without back pain显示文摘 | Jensen MC Brant-Zawadzki MN Obuchowski N | 1994 | N Engl J Med1994，331，2： | 1 |
| 19 | Impact of proteinuria and glo- merular filtration rate on risk of thromboembolism in atrial fibrilla- tion: the anticoagulation and risk factors in atrial fibrillation ( ATRIA ) study 显示文摘 | Go AS Fang MC Udaltsova N | 2009 | Circulation2009，119，10： | 1 |
| 20 | Geometric integration using discrete gradients 显示文摘 | MC LACHLAN R I QUISPEL G R W ROBIDOUX N | 1999 | Phil Trans R Soc Lond A1999，357，： | 1 |
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