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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 3 | A simple method for the precise determination of ≥ 40 trace elements in geological samples by ICPMS using enriched isotope internal standardisafion显示文摘 | Eggins S M Woodhead J D Kinsley L P J Mortimer G E Sylvester P McCulloch M T Hergt J M Handler M R | 1997 | Chem Geol1997，134，4： | 1 |
| 4 | Stromal mesenchymal progentor cellsin process citation显示文摘 | Ghilzon R McCulloch CA Zohar R | 1999 | Leuk Lymphoma1999，32，34： | 1 |
| 5 | Chirped Fiber Bragg Grating Detonation Velocity Sensing 显示文摘 | Rodriguez G Sandberg R L McCulloch Q | 2013 | Re- view of Scientific Instruments2013，84，01： | 1 |
| 6 | Mechanisms for the behavior of carbon films during annealing显示文摘 | Mcculloch D G Peng J L Mckenzie D R | 2004 | Phys Rev B2004，70，08： | 1 |
| 7 | Strornal mesenchmal progenitor cells in process Citation显示文摘 | Ghilzon R McCulloch CA Zohar R | 1999 | Leuk Lymphoma1999，32，34： | 1 |
| 8 | Stromal mesenchymal progenitor cells显示文摘 | Ghilzon R McCulloch CA Zohar R | | 0，，3： | 1 |
| 9 | Model-based detection of lung nodules in computed tomography exams显示文摘 | MCCULLOCH C C KAUCIC R A MENDONG P R | 2004 | Acad Radiol2004，11，3： | 1 |
| 10 | Characterization of stromal progenitor cells enriched by flow cytometry显示文摘 | Zohar R Sodek J McCulloch CA | 1997 | Blood1997，90，9： | 1 |
| 11 | Bayesian Anglysis of Antoregressive Time Series Via the Bibbs Sampler显示文摘 | McCulloch R E Tsay R S | 1994 | Journal of Time Series Analysis1994，，15： | 1 |
| 12 | Characterization of stromal progenitor cells enriched by flow cytometry显示文摘 | Zohar R Sodek J McCulloch CA | | 0，，09： | 1 |
| 13 | Adaptive Bayesian wavelet shrinkage显示文摘 | Chipman H A Kolaczyk E D McCulloch R E | 1997 | J Amer Statist Assoc1997，92，： | 1 |
| 14 | Quantifying the pH 'vital effect' in the temperate zooxanthellate coral Cladocora caespitosa: Validation of the boron seawater pH proxy显示文摘 | Trotter J Montagna P McCulloch M Silenzi S Reynaud S Mortimer G Martin S Ferrier-Pags C Gattuso J P Rodolfo- Metalpa R | 2011 | Earth Planet Sci Lett2011，303，34： | 1 |
| 15 | Characterization of stromal ?rogenitor ceils enriched by flow cytometry显示文摘 | Zohar R Sodek J McCulloch CA | 1997 | Blood1997，90，9： | 1 |
| 16 | Adaptive Bayesian wavelet shrinkage显示文摘 | Chipman H A Kolaczyk E D McCulloch R E | 1997 | J Amer Statist Assoc1997，92，440： | 1 |
| 17 | Geochemicaland Nd- Sr isotopic composition of deep- sea turbidites: crustalevolution and plate tectonic associations 显示文摘 | McLennan S M Taylor S R McCulloch M T | 1990 | Geochimica etCosmochimicaActa1990，54，7： | 1 |
| 18 | Statistical analysis of economic time series via Markov switching models 显示文摘 | McCulloch R E Tsay R S | 1994 | Journal of time series analysis1994，15，5： | 1 |
| 19 | Chondrocyte inter- actions with porous titanium alloy and calcium polyphosphate substrates 显示文摘 | Ciolfi V J Pilliar R McCulloch C | 2003 | Biomaterials2003，24，26： | 1 |
| 20 | Adaptive Bayesian wavelet shrinkage 显示文摘 | CHIPMAN H A KOLACZYK E D McCULLOCH R E | 1997 | Journal of the American Statistics Association1997，92，440： | 1 |
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