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| 1 | Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?显示文摘Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and deaths.Alcohol is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and deficiencies.Nutrients can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease pathogenesis.Notably,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene transcription.This review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to ALD.The review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD. | Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain Shirish Barve | 2011 | World Journal of Gastroenterology2011，17，20： | 6 |
| 2 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 3 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 4 | Advances in alcoholic liver disease显示文摘 | Beier J I Arteel G E McClain C J | 2011 | Curt Gastroenterol Rep2011，13，1： | 1 |
| 5 | Increased vascularization in mice overexpressing angiopoietin - 1 显示文摘 | McClain J Thurston G | 1998 | Science1998，282，5388： | 1 |
| 6 | Hepatitis B virus replication is associated with an HBx - dependent mitochondrion-regulated increase in cytosolic calcium levels 显示文摘 | McClain SL Clippinger A J Lizzano R | 2007 | J Virol2007，81，12： | 1 |
| 7 | Oxidative stress induced apoptosis prevented by tronox显示文摘 | Forest V J Kang Y H McClain D E | 1994 | Free Radic Buol Med1994，16，： | 1 |
| 8 | Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery 显示文摘 | Haddow JE Cleary - Goldman J McClain MR | 2010 | Obstet Gynecol2010，116，1： | 1 |
| 9 | Adsorption of N2 and CO2 on zeolite X exchanged with potassium, barium, or lanthanum显示文摘 | Siporin Stacey E McClaine Brian C Davis Robert J | 2003 | Langmuir2003，19，： | 1 |
| 10 | Electrostatic shielding in patterned carbon nanotube field emission arrays 显示文摘 | McClain D Wu J Tavan N | 2007 | J Phys Chem C2007，111，： | 1 |
| 11 | Yhyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery显示文摘 | Haddow J E Cleary-Goldman J McClain M R | 2010 | Obstetrics & Gynecology2010，116，1： | 1 |
| 12 | S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice显示文摘 | SONG Z MCCLAIN C J CHEN T | 2004 | Pharmacology2004，71，： | 1 |
| 13 | Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to children显示文摘 | Kain ZN Maclaren J Mcclain BC | 2007 | Anesthesiology2007，107，4： | 1 |
| 14 | Design of nonionic surfactants for supercritical carbon dioxide 显示文摘 | McClain J B Betts D E Canelas D A | 1996 | Science1996，274，5295： | 1 |
| 15 | Epoch length and accelerometer outputs in children: comparison to direct observation 显示文摘 | MCCLAIN J J ABRAHAM T L BRUSSEAU JR T A | 2008 | Med Sci Sport Exe2008，40，12： | 1 |
| 16 | Biospheric primary production during an ENSO transition 显示文摘 | Behrenfeld M J Randerson J T McClain C R | 2001 | Science2001，291，5513： | 1 |
| 17 | Processes controlling interannual variations in wintertime (Northeast Monsoon) primary productivity in the central Arabian Sea显示文摘 | Wiggert J D Murtugudde R G McClain C R | 2002 | Deep Sea Research Part Ⅱ:Topical Studies in Oceanography2002，49，12： | 1 |
| 18 | Cytokines in alcoholic liver disease显示文摘 | Mcclain C J Brave S Deaciue I | 1999 | Semin Liver Dis1999，19，： | 1 |
| 19 | Organic matter and nutrient dynamics in river corridors of the Amazon basin and their response to anthropogenic change 显示文摘 | Richey J E Wilhelm S R McClain M E | 1997 | Environmental Impact1997，49，12： | 1 |
| 20 | Decreased serum adiponectin:an early event in pediatric nonalco-holic fatty liver disease显示文摘 | Louthan MV Barve S McClain C J | 2005 | J Pediatr2005，147，6： | 1 |
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