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64篇 您的检索式:作者名="Mcewan E"
    题名 作者 年代 出处 被引量
1A sting in the tail: the N-terminal domain of the androgen receptor as a drug target显示文摘在前列腺癌症(PCa ) 的开始和前进的雄激素受体(AR ) 的角色很好被建立。AR ligand 有约束力的领域(LBD ) 的竞争抑制是采用在最近的年里与疾病作斗争的 antiandrogen 治疗的主食。然而,他们的功效被抵抗的出现经常限制了,通过点变化,和受体截断调停了。作为结果,为病人与的预后恶意阉割抵抗疾病遗体穷人。AR 的氨基终端的域(NTD ) 被显示了为 AR 功能批评。它的模块化的激活功能(AF-1 ) 在蛋白质蛋白质相互作用为基因规定和参予是重要的。由于领域的内在地混乱的结构,然而,它的潜力在过去被斥为治疗学的干预的一个候选人。小分子 EPI-001 的最近的出现提供了 AR-NTD 能治疗学地被指向的证据,独立于 LBD。AR-NTD 指向有潜力破坏在 AR 和它的 coregulatory 绑定搭挡之间的多重分子间的相互作用,除了在 AR 的领域之间的 intramolecular 串音。直接指向这些蛋白质蛋白质相互作用或 NTD 的治疗学应该也对新兴的 AR 有功效拼接可以在 PCa 起一个作用的变体前进。这评论将在 AR 功能讨论内在的混乱的角色并且说明新兴的治疗怎么可能在 PCa 指向 NTD。Amy E Monaghan Iain J McEwan 2016Asian Journal of Andrology2016,18,5:3
2Crystal structure of the factor XI zymogen reveals a pathway for transactivation显示文摘Papagrigoriou E McEwan PA Walsh PN 2006Nat Struct Mol Biol2006,13,6:1
3Autophagic targetingof Src promotes Cancer cell survival following reduced FAKsignalling显示文摘Sandilands E Serrels B Mcewan DG 2012Nat Cell Biol2012,14,1:1
4World's fastest solid-state digitizer显示文摘McEwan T E Kilkenny J D Dallum G 1994Energy and Technology Review1994,16,:1
5World's fastest solid-state digitizer显示文摘McEwan T E Kilkenny J D Dallum G 1994Energy and Technology Review1994,94,4:1
6Effect of FX dialysers on systemic inflammation and quality of life in chronic haemodialysis patients显示文摘BOUDVILLE N HORNER M McEWAN E 2009Blood Purif2009,27,2:1
716S rDNA library-based analysis of ruminal bacterial diversity 显示文摘EDWARDS J E MCEWAN N R TRAVIS A J 2004Antonie Van Leeuwenhoek2004,,3:1
8Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours显示文摘McEwan C Owen J Stride E 2015J Control Release2015,203,:1
9The patho- logical changes and polymorphonuclear and mast cell responses in the skin of specific pathogen-free lambs following primary and secondary challenge with Orf virus 显示文摘Jenkinson D M Mcewan P E Onwuka S K 1990Vet Dermatol1990,1,:1
1016S rDNA library-based analysis of ruminal bacterial diversity显示文摘Edwards E J McEwan R N Travis J A 2004Antonie Van Leeuwenhoek2004,86,3:1
11Effect of FX dialysers on systemic inflammation and quality of life in chronic haemodialysis patients显示文摘Boudville N Horner M McEwan E 2009Blood Purif2009,27,:1
1216S rDNA library-based analysis of ruminal bacterial diversity 显示文摘EDWARDS J E MCEWAN N R TRAVIS A J 2004Antonie van Leeuwenhoek2004,86,3:1
13The effects of a probiotic yeast on the bacterial diversity and population structure in the rumen of cattle显示文摘Pinloche E N McEwan J P M Bayourthe C 2013PLoS One2013,8,67:1
14Micropower impulse radar 显示文摘Azevedo S McEwan T E 1997Potentials IEEE1997,16,2:1
15World's fastest solid-state digitizer显示文摘 Kilkenny J D Dallum G 1994Energy and Technology Review1994,,4:1
16An NAD+ dependent glutamatede hydrogenase cloned from the ruminal ciliate protozoan,Entodinium caudatum显示文摘Newbold C J McEwan N R Calza R E 2005FEMS Microbiology Letters2005,247,:1
1716S rD- NA library based analysis of ruminal bacterial diversi- ty显示文摘Edwards J E Mcewan N R Travis A J 2004Antonievan Leeuwenhoek2004,3,:1
18Effect of FX dialysers on systemic inflammation and quality of life in chronic hamedialysis patients显示文摘Boudville N Horner M McEwan E 2009Blood Purif2009,27,2:1
19Compact WLAN disc antennas 显示文摘McEwan N J Abd-Alhameed R A Ibrahim E M 2002IEEE Trans Antennas Propag2002,50,12:1
20The effects of a probiotic yeast on the bacterial diversity and population structure in the rumen of cattle显示文摘PINLOCHE E MCEWAN N MARDEN J P 2013PLoS One2013,8,67:1
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