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| 1 | 中医药在巴西的发展现状与分析显示文摘巴西医疗保险以统一医疗体系(Unified Health System,SUS)的免费医疗为主、私人保险为补充,已实现全民享有基本医疗服务。导致该国居民死亡的主要疾病是缺血性心脏病、脑卒中、下呼吸道感染,近年来AD、慢性肾脏病及糖尿病的发病率显著增高。以针灸为代表的中医疗法在19世纪初传入巴西,目前针灸治疗已得到较广泛的认可和应用,被纳入SUS,并在多所高校开设相关课程,但中医药整体特色有待加强,从业人员对中药的理解、运用不足,以及中医药教育缺乏规范等问题限制了中医药在巴西的发展。建议通过发挥中医药治未病的特色,加大中药研发力度并扩大市场,规范中医教育等措施,促进两国在中医药领域的广泛合作,推动中医药在巴西的发展与传播。 | 李皓月 党迎迎 Thaís Salles Araujo Fatima Terezinha Pelachini Farias Jaime Amador Soares Graciela Mendonça da Silva de Medeiros 于涛 魏竞竞 赵静 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，5： | 5 |
| 2 | Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation显示文摘Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding. | Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 3 | Epidemiology of upper gastrointestinal symptoms in Brazil(Epi Gastro):A population-based study according to sex and age group显示文摘AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease(GERD)and dyspepsia in South America.METHODS:A telephone survey was conducted among adult owners of land-based telephones in S?o Paulo,Brazil,using previously validated computer-assisted sampling and survey protocols.The Portugueselanguage survey included(1)sociodemographic characteristics(e.g.,weight,height,smoking)and comorbidities;(2)dietary habits;(3)presence of symptoms consistent with GERD or dyspepsia within the prior 3mo;and(4)use of medications and other therapies to manage symptoms.Data were stratified post-hoc into three homogeneous geographical regions of S?o Paulo according to the Social Exclusion Indices of the districts and postal codes.Survey response data from each respondent were weighted by the numbers of adults and landline telephones in each household.The analyses were weighted to account for sampling design and to be representative of the S?o Paulo population according to city census data.RESULTS:Among 4570 households contacted,an adult from 3050(66.7%)agreed to participate.The nonresponse rate was 33.3%.The mean(SE)respondent age was 42.6(16.0)years.More than half of all respondents were women(53.1%),aged 18 through 49 years(66.7%),married or cohabitating(52.5%),and/or above normal-weight standards(i.e.,35.3%overweight and 16.3%obese).A total of 26.5%of women were perimenopausal.More than 20%of respondents reported highly frequent symptoms consistent with GERD(e.g.,gastric burning sensation=20.8%)or dyspepsia(e.g.,abdominal swelling/distension=20.9%)at least once per month.Prevalences of these symptoms were significantly(approximately 1.5-to 2.0-fold)higher among women than men but did not vary significantly as a function of advancing age.For instance,14.1%of women reported that they experienced stomach burning(symptom of GERD)at least twice per week,compared to 8.4%of men(P=0.012 byχ2 test).A total of 15.7%of women reported that they experienced abdominal swelling(symptom of dyspepsia)at least twice per week,compared to 6.4%of men(P<0.001byχ2 test).Despite frequent manifestations of GERD or dyspepsia,most(≥90%)respondents reported that they neither received prescription medications fromphysicians,nor took behavioral measures(e.g.,dietary modifications),to manage symptoms.CONCLUSION:Symptoms consistent with dyspepsia and GERD are prevalent in Brazil and represent major public-health and clinical challenges. | Maria do Rosário Dias de Oliveira Latorre Aline Medeiros da Silva Décio Chinzon Jaime N Eisig Telma RP Dias-Bastos | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 4 | Phytochemical study guided by the myorelaxant activity of the crude extract, fractions and constituent from stem bark of Hymenaea courbaril L.显示文摘 | Gabrieli Penha Bezerra Roberto Wagner da Silva Góis Teresinha Silva de Brito Francisco José Batista de Lima Mary Anne Medeiros Bandeira Nirla Rodrigues Romero Pedro Jorge Caldas Magalh?es Gilvandete Maria Pinheiro Santiago | 2013 | Journal of Ethnopharmacology2013，，： | 1 |
| 5 | Acute myeloid leukae miain the elderly:a review 显示文摘 | Pollyea DA Kohrt HE Medeiros BC | 2011 | Br J Haematol2011，152，5： | 1 |
| 6 | Malignant fibrous bistio- cytoma of the spermatic cord: report of two cases and review of the literature显示文摘 | Lin BT Harvey DA Medeiros LJ | 2002 | Mod Pathol2002，15，1： | 1 |
| 7 | Quantitative analysis of trigonelline in some Annona species by proton NMR spectroscopy显示文摘A quantitative ^(1)H NMR method(qHNMR)was used to measure the trigonelline content in the leaves of six species of the Annona genus.The methodology employed compared the intensities of the signals at δ9.14(H-2)andδ0.00,the internal standard TSP-d_(4).This measuring method was able to establish the concentration of trigonelline in the range from 0.67 to 10.04 mg·g^(-1) depending on the investigated extract. | Alan Rodrigues Teixeira MACHADO Gisele Avelar LAGE Felipe da Silva MEDEIROS José Dias de Souza FILHO Lúcia Pinheiro Santos PIMENTA | 2013 | Natural Products and Bioprospecting2013，3，4： | 1 |
| 8 | Exercise training reduces insulin resistance and upregulates the roTOR/ p70S6k pathway in cardiac muscle of diet-induced obesity rats 显示文摘 | MEDEIROS C FREDERICO M J DA L G | 2011 | J Cell Physiol2011，226，3： | 1 |
| 9 | Accuracy of CA125 in diagnosis of ovarian tumors: a quantitative systematic review显示文摘 | Medeiros LR Rosa DD Da Rosa MI | 2009 | Eur J Obstet Gynecol Reprod Biol2009，142，2： | 1 |
| 10 | Accuracy of CA 125 in the diagnosis of ovarian tumors: a quantitative systematic review显示文摘 | Medeiros LR Rosa DD da Rosa MI | 2009 | Eur J Obstet Gynecol Reprod Biol2009，142，2： | 1 |
| 11 | miRNAs as biomarkers of atrial fibrillation显示文摘 | Ananí lia Medeiros Gomes da Silva Vivian Nogueira Silbiger | 2014 | Biomarkers2014，，： | 1 |
| 12 | Accuracy of CA 125 in the diagnosis of ovarian tumors:a quantitative systematic review显示文摘 | Medeiros LR Rosa DD da Rosa MI | 2009 | Eur J Obstet Gynecol Reprod Biol2009，142，2： | 1 |
| 13 | Respiratory manifestations of systemic lupus erythematosus:Old and new concepts显示文摘 | Pego-Reigosa JM Medeiros DA Isenberg DA | | 0，，： | 1 |
| 14 | Accuracy of CA 125 in the diagnosis of ovarian tumors: A quantitative systematic review显示文摘 | Lidia Rosi Medeiros Daniela Dornelles Rosa Maria Inês da Rosa Mary Clarisse Bozzetti | 2008 | European Journal of Obstetrics and Gynecology2008，，： | 1 |
| 15 | Airway proteoglycans are differentially altered in fatal asthma 显示文摘 | de Medeiros Matsushita M da Silva LF dos Santos MA | 2005 | J Pathol2005，207，1： | 1 |
| 16 | Management of melon bacterial blotch by plant beneficial bacte- ria 显示文摘 | Medeiros F H V Moraes I S F da Silva Neto E ]3 | 2009 | Phytoparasitica2009，37，5： | 1 |
| 17 | Accuracy of CA 125 in the diagnosis of owtrian tumors: a quantitative systematic review 显示文摘 | Medeiros LR Rosa DD da Rosa MI | 2009 | Eur J ()bstet Gynecol Reprod Biol2009，142，2： | 1 |
| 18 | Pseudoneoplastic lesions of the female genital tract显示文摘 | Medeiros F Bell DA | 2010 | Arch Pathol Lab Med2010，134，3： | 1 |
| 19 | Neutrophils LL-37 migrate to the nucleus during overwhelming infection显示文摘 | Pinheiro da Silva F Medeiros M C Santos A B | 2013 | Tissue Cell2013，45，5： | 1 |
| 20 | Bradykinin B1 receptor expression induced by tissue damage in the rat portal vein:a critical role for mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways 显示文摘 | Medeiros R Cabrini DA Ferreira J | 2004 | Circ Res2004，94，10： | 1 |
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