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| 1 | CD26分子在正常皮肤组织和瘢痕疙瘩组织中成纤维细胞表达的差异分析显示文摘目的探究CD26表面分子在正常皮肤组织和瘢痕疙瘩成纤维细胞中表达的差异。方法正常皮肤成纤维细胞(NFs)组的正常皮肤组织取自接受腹部整形术的10例患者;瘢痕疙瘩成纤维细胞(KFs)组瘢痕疙瘩组织取自此前未经过任何治疗的10例瘢痕疙瘩患者的胸部和腹部。利用酶消化法获得原代KFs和NFs,应用流式分析技术检测CD26表面分子在2组细胞中的表达差异。用流式分选技术对NFs和KFs组中CD26表达阳性(CD26+)与表达阴性(CD26-)细胞进行分选,体外常规培养4 d后对细胞形态进行初步分析。结果 CD26表面分子在KFs和NFs中均可表达,但KFs组表达率(46.65±13.97)%明显高于NFs组(24.75±16.85)%,差异具有统计学意义(P<0.01)。经流式分选后,CD26+与CD26-细胞群在NFs与KFs组中形态均无明显差异。结论 CD26分子在瘢痕疙瘩组织成纤维细胞中的表达率明显高于正常皮肤组织成纤维细胞中的表达率,CD26-和CK26+细胞群在形态上无明显差异。 | 辛宇 Melia Bogari Zin Mar Aung 陈伟 柴岗 张艳 | 2017 | 中国美容整形外科杂志2017，28，1： | 5 |
| 2 | Physical basis for the symmetries in the Friedmann-Robert son-Walker metric显示文摘 | Fulvio Melia | 2016 | Frontiers of physics2016，11，4： | 2 |
| 3 | Intravitreal Ranibizumab for Diabetic Macular Edema with Prompt versus Deferred Laser Treatment显示文摘 | Michael J. Elman Haijing Qin Lloyd Paul Aiello Roy W. Beck Neil M. Bressler Frederick L. Ferris Adam R. Glassman Raj K. Maturi Michele Melia | 2012 | Ophthalmology2012，，11： | 2 |
| 4 | 半侧颜面短小畸形中的下颌骨畸形与外耳畸形的相关性分析显示文摘目的分析半侧颜面短小畸形(Hemifacial Microsomia,HFM)中的下颌骨畸形与外耳畸形之间的统计学相关性。方法以2013年1月至2014年12月来院就诊的118例HFM患儿为研究对象,根据改良的OMENS Plus分类系统进行分型,全部病例行面部多角度拍照、面部三维扫描及头部CT检查。根据照片及面部三维扫描对外耳畸形进行分类,根据头部CT结果进行三维重建,采用Mimics软件进行下颌骨测量并分类。应用逻辑回归模型对下颌骨畸形和外耳畸形进行统计学相关性分析。结果 118例患者中,全部患者都表现为下颌骨畸形,其中M1型27例(22.9%),M2A型45例(38.1%),M2B型41例(34.7%),M3型5例(4.2%)。所有患者都存在耳部轻度到重度畸形,其中E1型20例(16.9%),E2型24例(20.3%),E3型51例(43.2%),E4型23例(19.5%)。相关系数(P=0.647)显示,两者之间没有显著的统计学相关性。结论本组HFM患者中的下颌骨畸形与外耳畸形的严重性没有统计学相关性。 | Andy Tan 辛宇 Melia Bogari 林力 徐海凇 张艳 柴岗 | 2016 | 组织工程与重建外科杂志2016，12，1： | 2 |
| 5 | 聚乙二醇干扰素/利巴韦林治疗丙型肝炎期间发生的感染与绝对淋巴细胞计数下降相关显示文摘虽然聚乙二醇干扰素(PEG-INF)治疗丙型肝炎期间常引起骨髓抑制,但白细胞计数的下降与发生感染风险的关系仍未确定。一项随机、平行、多中心Ⅲ期IDEAL(Individualized Dosing Efficacy vs Flat Dosing to Assess Optimal Pegylated Interferon Therapy)研究,旨在确定PEGINF/利巴韦林治疗丙型肝炎期间感染发生的概率和危险因素。 | Melia MT Brau N Poordad F 何高丽 张菁 | 2015 | 中国感染与化疗杂志2015，15，4： | 2 |
| 6 | Protein and humic acid adsorption on to hydrophilic membrane surfaces: effect of pH and ionic strength 显示文摘 | JONES K L O'MELIA C R | 2000 | J Membrane Sci2000，165，1： | 1 |
| 7 | 显示文摘 | Adler J Baldwin P M Melia C D | 1994 | Starch1994，46，7： | 1 |
| 8 | Another look at safety climate and safety behavior: Deepening the cognitive and social mediator mechanisms显示文摘 | Fugas C S Silva S A Melia J L | 2012 | Accident Analysis & Prevention2012，45，1： | 1 |
| 9 | Hydrodynamics based transfection in normal and fibrotic rats显示文摘AIM: Hydrodynamics based transfection (HBT), the injection of a large volume of naked plasmid DNA in a short time is a relatively simple, efficient and safe method for in vivo transfection of liver cells. Though used for quite some time, the mechanism of gene transfection has not yet been elucidated. METHODS: A luciferase encoding plasmid was injected using the hydrodynamics based procedure into normal and thioacetamide-induced fibrotic Sprague Dawley rats. Scanning and transmission electron microscopy images were taken. The consequence of a dual injection of Ringer solution and luciferase pDNA was followed. Halofuginone, an anti collagen type I inhibitor was used to reduce ECM load in fibrotic rats prior to the hydrodynamic injection. RESULTS: Large endothelial gaps formed as soon as 10’ following hydrodynamic injection; these gradually returned to normal 10 d post injection. Hydrodynamic administration of Ringer 10 or 30 m prior to moderate injection of plasmid did not result in efficient transfection suggesting that endothelial gaps by themselves are not sufficient for gene expression. Gene transfection following hydrodynamic injection in thioacetamide induced fibrotic rats was diminished coinciding with the level of fibrosis. Halofuginone, a specific collagen typeⅠ inhibitor, alleviated this effect. CONCLUSION: The hydrodynamic pressure formedfollowing HBT results in the formation of large endothelial gaps. These gaps, though important in the transfer of DNA molecules from the blood to the space of Disse are not enough to provide the appropriate conditions for hepatocyte transfection. Hydrodynamics based injection is applicable in fibrotic rats provided that ECM load is reduced. | Rita Yeikilis Shunit Gal Natalia Kopeiko Melia Paizi Mark Pines Filip Braet Gadi Spira | 2006 | World Journal of Gastroenterology2006，12，38： | 1 |
| 10 | The Influence of Milk k-Cn and β-Lg Phenotype on Fatty Acid Composition of Milk from Reggiana Cows显示文摘 | MELIA S LOSI G CASTAGNETTI G B | 2009 | Dairy Science Technology2009，89，1： | 1 |
| 11 | Crystal nucleation from aqueous solution显示文摘 | Melia T P | 1965 | Appl Chem1965，15，7： | 1 |
| 12 | Review of limited sys-temic absortion of orlistat, a lipase inhibitor, in healthy humanvolunteers 显示文摘 | ZHI J MELIA AT EGGERS H | 1995 | Clin Pharmacol1995，35，11： | 1 |
| 13 | Kinetics of deposition of colloidal particles in porous media显示文摘 | O'Melia C R | 1990 | American Chemical Society1990，24，： | 1 |
| 14 | Aluminum-fulvic Acid Interactions: Mechanisms and Applications 显示文摘 | Thomas R Hundt Charles R O'Melia | 1988 | American Water Works Association1988，80，4： | 1 |
| 15 | Stoichiometry of coagulation revisited显示文摘 | Shin J Y Spinette R F O'Melia C R | 2008 | Environmental Science and Technology2008，7，： | 1 |
| 16 | Review of limited sys-temic absortion of orlistat, a lipase inhibitor,in healthy humanvolunteers 显示文摘 | ZHI J MELIA AT EGGERS H | 1995 | Clin Pharmacol ’1995，35，11： | 1 |
| 17 | Linear spectral mixture modeling to estimate vegetation amount from optical spectral data显示文摘 | GARCIA-HARO F J GILABERT M A MELIA J | 1996 | International Journal of Remote Sensing1996，17，： | 1 |
| 18 | Water and waste water filtration : concepts and applications 显示文摘 | Yao K-M Habibian M T O'Melia C R | 1971 | Environmental Science and Technology1971，，1： | 1 |
| 19 | Functional cou- pling of human L-type Ca^2+ channel and angiotensin AT1A receptor coexpressed in Xenopus oocytes: Involvement of the carboxylterminal Ca^2+ sensors 显示文摘 | Oz M Melia MT Soldatov N | 1998 | Mol Pharmacol1998，54，6： | 1 |
| 20 | Water and wastewater filtration : Concepts and applications 显示文摘 | Yao K M Holsibian M T Melia C R O | 1971 | Environmental Science and Technology1971，5，： | 1 |
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