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| 1 | Innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis显示文摘BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori(H.pylori)infection and increased risk of gastric cancer.AIM To identify the risk factors associated with H.pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.METHODS We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with H.pylori-induced chronic gastritis,and Group 2–control group.RESULTS Rural area and poor living conditions were significantly associated with H.pylori chronic gastritis(P=0.0042/P<0.0001).Both positive immunoglobulin A anti H.pylori and the rapid urease test were significantly associated with H.pylori infection(P<0.0001).Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with H.pylori chronic gastritis(P=0.111/P=0.284).We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation. | Lorena Elena Meliț Cristina Oana Mărginean Maria Oana Săsăran Simona Mocan Dana Valentina Ghiga Alina Bogliş Carmen Duicu | 2021 | World Journal of Clinical Cases2021，9，23： | 2 |
| 2 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 3 | Plutonium and americium determination in mosses by laser ablation ICP-MS combined with isotope dilution technique显示文摘 | BOULYGA S F DESIDERI D MELI M A | 2003 | International Journal of Mass Spec- trometry2003，226，： | 1 |
| 4 | The dopamine hypothesis of drug addiction:hypodopaminergic state显示文摘 | Melis M Spiga S Diana M | 2005 | Int Rev Neurobiol2005，63，： | 1 |
| 5 | Frequency and initiation of debris flows in Grand Canyon, Arizona 显示文摘 | Griffiths P G Webb R H Melis T S | 2004 | Journal of Geophysical Research2004，，109： | 1 |
| 6 | Seismic Load Tests on Two Story Waffle Flat Plate Structure显示文摘 | RODRIGUEI M E SANTIAGO S MELI S | 1995 | Journal of Structural Engineering ASCE1995，9，12： | 1 |
| 7 | Plasma endothelin-1 levels and albumin excretion rate in normotensive, microalbuminurie type 2 diabetic patients显示文摘 | Bruno CM Meli S Marcinno M | 2002 | Biol Regul Homeost Agents2002，16，2： | 1 |
| 8 | Epidemiologic study of mortality during the Summer 2003 heat wave in Italy显示文摘 | Conti S Meli P Minelli G | | 0，，03： | 1 |
| 9 | Autism and phenylketonuria显示文摘 | Baieli S Pavone L Meli C | 2003 | J Autism Dev Disord2003，33，2： | 1 |
| 10 | Endothelin and diabetic nephropathy: a new pathogenetic factor?显示文摘 | MELI S BRUNO CM | 2001 | Panminerva-Med2001，43，1： | 1 |
| 11 | Effects of chronic administration of Stevia rebaudiana on fertility in rats显示文摘 | MELIS M S | 1999 | Journal of Ethnopharmacology1999，67，2： | 1 |
| 12 | ACTH- and alpha-MSH-induced grooming, stretching, yawning and penileerection in male rats: site of action in the brain and role ofmelanocortin receptors 显示文摘 | Argiolas A Melis M R Murgia S | 2000 | Brain Research Bulletin2000，51，5： | 1 |
| 13 | The state of the Colorado River ecosystem in Grand Canyon: lessons from 10 years of adaptive ecosystem manage- ment 显示文摘 | Lovich J Melis T S | 2007 | International Journal of River Basin Management2007，5，3： | 1 |
| 14 | Reduction of thermal residual stresses in advanced metallic composites based upon a compensating/compliant layer concept 显示文摘 | ARNOLD S M ARYA V K MELIS M E | 1992 | Journal of Composite Materials1992，26，9： | 1 |
| 15 | Plasma endothelinl levels and albumin excretion rate in normotensive, microalbuminuric type 2diabetic patients 显示文摘 | Bruno CM Meli S Marcinno M | 2002 | J Biol Regul Homeost Agents2002，16，2： | 1 |
| 16 | Reduction of Thermal Stresses in Advanced Metallic Composites Based upon a Compensating/Compliant Layer Concept显示文摘 | Arnold S M Arya V K Melis M E | 1992 | J Compos Ma- ter1992，26，9： | 1 |
| 17 | Peptide receptor radionuclide therapy using radiolabeled somatostatin analogs:focus on future developments 显示文摘 | BISON S M KONIJNENBERG M W MELIS M | 2014 | Clin Transl Ima- ging2014，2，1： | 1 |
| 18 | Molecular characteriza- tion of two different strains of haemotropic mycoplas- mas from a sheep flock with fatal haemolytic anaemia and concomitant Anaplasma ovis infection显示文摘 | HORNOK S MELI M L ERDOS A | 2009 | Vet gicrobiol2009，136，34： | 1 |
| 19 | Matrix metalloproteinase-9 in pneumococcal meningitis:activation via an oxidative pathway显示文摘 | Meli D N Christen S Leib S L | 2003 | J Infect Dis2003，187，9： | 1 |
| 20 | First molecular iden- tification of Mycoplasma ovis and'gandidatus haemoo- vis'from goat,with lack of haemoplasma PCR positivity in lice显示文摘 | HORNOK S HAJTO S I MELI M L | 2012 | ActaYetHung2012，60，3： | 1 |
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