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| 1 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Light interception and lint yield of narrow-row cotton显示文摘 | Heithoh J J Pettigrew W T Meredith W R | 1992 | Crop Science1992，32，： | 1 |
| 4 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Hysiol2006，290，： | 1 |
| 5 | Aortic stiffness affects the coronary blood flow response to percutaneous coronary intervention显示文摘 | LEUNG M C MEREDITH I T CAMERON J D | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
| 6 | Role of endothelium in ischemic coronary syndrom显示文摘 | MEREDITH I T ANDERSON T J UEHATA A | 2003 | Am J Cardiol2003，72，8： | 1 |
| 7 | Crop physiology& metabolism, Leaf gas exchange parameters vary among cotton genotypes显示文摘 | Pettigrew W T Meredith W R | 1994 | Crop Sei1994，，34： | 1 |
| 8 | How limiting factors drive agricultural adaptation to climate change显示文摘 | Meredith T N Mark L Margaret B | 2015 | Agriculture Ecosystem&Environment2015，200，： | 1 |
| 9 | Wall teiehoic acid function, biosynthesis, and inhibition显示文摘 | Swoboda J G Campbell J Meredith T C | 2010 | Chem Bio2010，11，2： | 1 |
| 10 | Dry matter production, nutrient uptake, and growth of cotton as affected by potassium fer tilization显示文摘 | Pettigrew W T Meredith W R | 1997 | Plant Nutrition1997，20，： | 1 |
| 11 | Exploring methods for rapid assessmentof woody vegetation in the Batemi Valley,North-central Tanzania显示文摘 | Smith W Meredith T C Johns T | 1999 | Biodiversity and Conservation1999，8，4： | 1 |
| 12 | Decision - tree earlywarning score ( DTEWS) validates the design of the National EarlyWarning Score ( NEWS ) 显示文摘 | Badriyah T Briggs JS Meredith P | 2014 | Resuscitation2014，85，5： | 1 |
| 13 | Light interception and lint yield of narrow-row cotton显示文摘 | HEITHOLT J J PETTIGREW W T MEREDITH W R | 1992 | Crop Science1992，32，： | 1 |
| 14 | Genotypic interactions with potassium and nitrogen in cotton of varied maturity显示文摘 | Pettigrew W T Heitholt J J Meredith W R | 1996 | Agronomy Journal1996，88，： | 1 |
| 15 | Oralerythromycin and the risk of sudden death from cardiac causes显示文摘 | RAY W A MURRAY K T MEREDITH S | 2004 | N Engl J Med2004，51，11： | 1 |
| 16 | Dry matter production,nutrientuptake,and growth of cotton as affected by potassium fertilization显示文摘 | Pettigrew W T Meredith W R | 1997 | Plant Nutrition1997，20，： | 1 |
| 17 | Paraquat poison- ing: clinical features and immediate general management 显示文摘 | Vale J A Meredith T J Buckley B M | 1987 | Hum Toxico1987，6，1： | 1 |
| 18 | Time course of plasma adhesion molecules in acute coronary syndromes显示文摘 | Meredith I T Farouque H M | 2002 | Coron Artery Dis2002，13，： | 1 |
| 19 | Genotypic interac- tions with potassium and nitrogen in cotton of varied maturity显示文摘 | Pettigrew W T Heitholt J J Meredith W R Jr | 1996 | Agronomy Journal1996，88，： | 1 |
| 20 | A Specificity-Enhancing Factor for the ClpXP Degradation Machine显示文摘 | Igor L Meredith S Robert T | 2000 | Science2000，289，： | 1 |
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