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| 1 | 面向21世纪的卒中新定义:美国心脏病学会和美国卒中学会声明显示文摘尽管脑血管病有着全球性影响且对其病理生理学的认识有了很多进步,但是'卒中'这一术语在临床实践、临床研究或公共卫生评估中的定义却不一致。传统的定义依据于临床,却没有考虑到科学技术的进步。美国心脏协会(AHA)和美国卒中协会(ASA)卒中分会组织了写作小组,为21世纪卒中新定义撰写专家共识性声明。中枢神经系统(CNS)梗死,指由缺血所导致的脑、脊髓或视网膜的细胞死亡,是基于持续性损害的神经病理学、神经影像学和(或)临床证据。CNS梗死表现为一个临床谱:缺血性卒中特指伴有明显症状的CNS梗死,而静息性梗死根据定义指未引起已知的症状的梗死。卒中也还包括脑出血和蛛网膜下腔出血。新定义的卒中结合了临床和组织学标准,可被用于实践、研究和公共卫生评估。 | 俞羚 董荃 宋叶平 江静雯 李卉 刘亮贤 苏爱萍 李焰生 Sacco RL Kasner SE Broderick JP Caplan LR Connors JJ Culebras A Elkind MS George MG Hamdan AD Higashida RT Hoh BL Janis LS Kase CS Kleindorfer DO Lee JM Moseley ME Peterson ED Turan TN Valderrama AL Vinters HV | 2013 | 神经病学与神经康复学杂志2013，10，2： | 188 |
| 2 | 肥胖和动脉老化:Whitehall Ⅱ队列主动脉僵硬度纵向研究显示文摘该研究旨在确定肥胖症是否中年后动脉硬化加速的独立预测因子。纳入Whitehall Ⅱ研究受试者男性3789例,女性1383例,平均年龄66岁,均接受颈-股动脉压检测,4年后再次进行测定。一般肥胖状况由体质量指数,中心肥胖由腰围和腰臀比,脂肪含量百分比由身体阻抗来评估。通过线性混合模型,对年龄、性别、种族和平均动脉压进行调整后,所有肥胖症测量指标与主动脉硬化[通过随访的脉搏波传导速度(pulse wave velocity,PWV)较基线增加值来确定]相关。 | 刘莉 叶鹏 Brunner EJ Shipley MJ Ahmadi-Abhari S Tabak AG McEniery CM Wilkinson IB Marmot MG Singh-Manoux A Kivimaki M | 2015 | 中华高血压杂志2015，23，6： | 8 |
| 3 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 4 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 5 | 中年成人平均动脉压的体位改变与动脉硬度的关系:Framingham心脏研究显示文摘Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults:the Framingham heart study. Hyperten- sion,2017,69(4) :685-690.站立位血压稳定调节受损可导致不良结果,包括跌倒、晕厥和定向障碍。平均动脉压(meanarterialpressure,MAP)通常在站立位时增加,然而,站立位MAP增加不足或减少可能导致脑灌注减少。已有研究报道,在动脉硬度增加的老年人中存在体位性低血压,年轻至中年人MAP的体位性改变与动脉硬度的相关性尚未阐明。该研究分析了Framingham心脏研究第3代队列中的受试者3205人(女性1693人,占53%)的直立性血压反应和全面血液动力学数据。 | Torjesen A Cooper LL Rong J Larson MG Hamburg NM Levy D Benjamin EJ Vasan RS Mitchell GF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，3： | 5 |
| 6 | 巨噬细胞、细胞因子和脓毒症显示文摘巨噬细胞激活以及巨噬细胞因子白介素1(IL-1)、白介素6(IL-6)和肿瘤坏死因子(TNF)分泌的增加与脓毒症的发生发展有着密切的联系。采用这些细胞因子的桔抗物(如TNF单抗、消炎痛等)以及用小剂量内毒素诱导内毒素耐受性均能降低巨噬细胞因子分泌反应并提高脓毒症动物的生存率。本文对有关进展作综合介绍。 | Walsh CJ León P O'Riordain MG Ayala A 密磊 | 1993 | 国外医学(创伤与外科基本问题分册)1993，14，1： | 3 |
| 7 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 8 | 基于胱抑素C和肌酐估算的肾小球滤过率差异及衰弱和不良结局的相关性显示文摘在之前的研究和实践中,尚未对基于胱抑素C水平估算的肾小球滤过率(estimated glomerular filtration rate,eGFR,eGFR胱抑素)和基于肌酐水平估算的eGFR(eGFR肌酐)之间差异的临床重要性和相关性进行评估。研究者旨在评估这些差异是否包含衰弱的重要信息。研究设计:一项收缩压干预试验(the systolic blood pressure intervention trial,SPRINT)的队列分析。设置与参与者:SPRINT(9 092例)高血压参与者在基线时检测血清肌酐、胱抑素C和衰弱水平。 | 袁源(摘译) 练桂丽(审校) Potok OA Ix JH Shlipak MG Katz R Hawfield AT Rocco MV Ambrosius WT Cho ME Pajewski NM Rastogi A Rifkin DE | 2021 | 中华高血压杂志2021，29，1： | 2 |
| 9 | Premenopausal bone loss in the lumbar spine and neck of femur: A study of 225 Caucasian women 显示文摘 | Rodin A Murby B Smith MA Caleffi M Fentiman I Chapman MG Fogelman I | 1990 | Bone1990，，11： | 1 |
| 10 | Functional characterization of a novel mutation in KCNA1 in episodic ataxia type 1 associated with epilepsy 显示文摘 | Spauschus A Eunson L Hanna MG | 1999 | Ann NYAcadSci1999，868，3： | 1 |
| 11 | Relationships between endometrial cytology and interval to first ovulation,and pregnancy in postpartum dairy cows in a single herd显示文摘 | Dourey A Colazo MG Barajas PP | 2011 | Res Vet Sci2011，91，3： | 1 |
| 12 | Evidence against an X-linked locus close to DXS7 determining visual loss susceptibility in British and Italian families with Leber hereditary optic neuropathy 显示文摘 | Sweeney MG Davis MB Lashwood A | 1992 | Am J Hum Genet1992，51，： | 1 |
| 13 | SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells显示文摘 | De Falco E Porcelli D Torella AR Straino S Iachininoto MG Orlandi A | 2004 | Blood2004，104，12： | 1 |
| 14 | Management of lung cancer in elder adults显示文摘 | Hurria A Kris MG | 2003 | CA Cancer J Clin2003，53，6： | 1 |
| 15 | Interaction of pseudomonas aeruginos with epithelial cells: identification of differentially regulaterted genes by expression microarray analysis of human cDNA显示文摘 | Ichikawa JK Norris A Bangera MG | 2000 | Proc Natl Acad Sci USA2000，97，17： | 1 |
| 16 | Immunologic aspects of chronic ob- structive pulmonary disease显示文摘 | Cosio MG Saetta M Agusti A | 2009 | N Engl J Meal2009，360，23： | 1 |
| 17 | Clinical and biomechanical assessment of patella resurfacing in total knee arthroplasty 显示文摘 | Berti L Benedetti MG Ensini A | 2006 | Clin Biomech2006，21，： | 1 |
| 18 | Immunologic aspects of chronic obstructive pulmonary disease显示文摘 | Cosio MG Saetta M Agusti A | 2009 | N Engl J Med2009，360，23： | 1 |
| 19 | Endothelin B receptor agonist, IRL- 1620, enhances angiogenesis and neurogenesis following cerebral ischemia in rats显示文摘 | Leonard MG Gulati A | | Brain Res0，1528，： | 1 |
| 20 | Pathophysiological concepts of stroke in hemodynamic risk zones--do hypoperfusion and embolism interact显示文摘 | Forster A Szabo K Hennerici MG | 2008 | Nat Clin Pract Neurol2008，4，4： | 1 |
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