6篇
您的检索式：作者名="Michael Fay"
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| 1 | Nasal foreign bodies in children显示文摘 | Michael Chi fai Tong Shun Yuen Ying Charles Andrew van Hasselt | 1996 | Intern J Pediatr Otorhinolaryngol1996，35，： | 1 |
| 2 | Identification of nitrated proteins in Alzheimer’s disease brain using a redox proteomics approach显示文摘 | Rukhsana Sultana H. Fai Poon Jian Cai William M. Pierce Michael Merchant Jon B. Klein William R. Markesbery D. Allan Butterfield | 2005 | Neurobiology of Disease2005，，1： | 1 |
| 3 | Transcanal endoscopic assisted skull base endolymphatic sac tumor resection: A rare disease with advanced technology显示文摘Endolymphatic sac tumors(ELSTs) are rare, papillary adenomatous tumors that arise from the endothelium of the endolymphatic sac. We demonstrate a difficult case of endolymphatic sac tumor and how it is managed via transcanal endoscopic assisted technique, with discussion of feasibility of transcanal approach to lateral skull base tumor. | Wai Tsz Chang Ka Yue Tam Hung Yao Kwan Ho Chow Michael Chi Fai Tong | 2020 | Journal of Otology2020，15，1： | 1 |
| 4 | Metalor- ganic deposition of high-Jc Ba2YCu3O7-δ thin films from trifluoroacetate precursor onto (100) SrTiO3 显示文摘 | Paul C McIntyre Michael J Cima Man Fai Ng | 1990 | J Appl Phys1990，68，8： | 1 |
| 5 | Economic Forces in the Lon- don Stock Market显示文摘 | Beenstock Michael Chan Kam - Fai | | 0，，01： | 1 |
| 6 | HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model显示文摘Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic circulation.The aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant glioma.Methods:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer cells.Blood and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse model.Results:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did PVP-HM.Pharmacokinetic study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this level.Cyclodextrin-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(P<0.05).Conclusions:In a mouse orthotopic brain tumor model,the intravenous co-administration of cyclodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans. | Wu Zeng Betty Yuen Kwan Law Vincent Kam Wai Wong Denise So Bik Chan Simon Wing Fai Mok Joyce Jia Ying Gao Rebecca Ka Yan Ho Xu Liang Jia Hao Li Ming Tsung Lee Weng Li Yoon Michael P Smolinski Johnson Yiu Nam Lau Christopher Wai Kei Lam Manson Fok | 2020 | Cancer Biology & Medicine2020，17，4： | 0 |
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