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| 1 | Safety of endoscopic retrograde cholangiopancreatography in pregnancy: Fluoroscopy time and fetal exposure, does it matter?显示文摘AIM: To estimate the fetal radiation exposure using thermoluminescent dosimeters (TLD's) in pregnant patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and assess its relevance. METHODS: Data on thirty-five therapeutic ERCPs conducted in pregnant patients from 2001 to 2009 were retrieved from a prospective database. Techniques to minimize fluoroscopy time were implemented and the fluoroscopy times captured. TLD's were placed on the mother to estimate the fetal radiation exposure and the results were compared to the maximum allowed dose of radiation to the fetus [0.005 gray (Gy)]. Obstetrics consultations were obtained and the fetus was monitored before and after the ERCP. Fluoroscopy wasperformed at 75 kVp. ERCP was performed with the patients supine by dedicated biliary endoscopists performing more than 500 cases a year. RESULTS: A total of 35 pregnant patients underwent ERCP and biliary sphincterotomy (14 in first trimester, 11 in second trimester, and 10 in third trimester). Mean maternal age was 25 years (range 16-37 years) and mean gestational age was 18.9 wk (range 4-35 wk). Mean fluoroscopy time was 0.15 min (range 0-1 min). For 23 women, the estimated fetal radiation exposure was almost negligible (< 0.0001 Gy) while for 8 women, it was within the 0.0001-0.0002 Gy range. Three women had an estimated fetal radiation exposure between 0.0002 and 0.0005 Gy and 1 woman had an estimated fetal radiation exposure greater than 0.0005 Gy. Complications included 2 post-sphincterotomy bleeds, 2 post-ERCP pancreatitis, and 1 fatal acute respiratory distress syndrome. One patient developed cholecystitis 2 d after ERCP. CONCLUSION: ERCP with modified techniques is safe during pregnancy, and estimating the fetal radiation exposure from the fluoroscopy time or measuring it via TLD's is unnecessary. | Ioana Smith Monica Gaidhane Allen Goode Michel Kahaleh | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 12 |
| 2 | β-酪蛋白与婴幼儿生长和发育显示文摘母乳是婴幼儿的首选营养源。世界卫生组织(WHO)建议婴儿出生后头6个月应完全以母乳喂养。此外,应坚持母乳辅以适当的固体食物喂养至少两年[1]。然而,并非所有婴儿均可得到母乳喂养,一些婴儿也无法获得捐赠母乳。在这种情况下需要用婴幼儿配方奶代替母乳。牛奶含有相对价廉的蛋白质与营养素且来源丰富,因此大多数婴幼儿配方奶均产自牛奶。但是,牛奶与母乳的蛋白质成分差异颇大。如,母乳主要含乳清蛋白,酪蛋白∶乳清蛋白约为40∶60(泌乳早期10∶90,泌乳后期50∶50),而牛奶的酪蛋白∶乳清蛋白则高达80∶20[2]。 | Michele J. Sadler Nicholas Smith | 2014 | 临床儿科杂志2014，32，2： | 7 |
| 3 | Plasma Membrane-Associated SCAR Complex Subunits Promote Cortical F-Actin Accumulation and Normal Growth Characteristics in Arabidopsis Roots显示文摘ARP2/3 建筑群, F 肌动朊聚合的高度保存的 nucleator,和它的使活跃之物, SCAR 建筑群,被显示了在叶起重要作用在 Arabidopsis 的表皮的房间形态发生。然而,疤和 ARP2/3 的细胞内部的地点和功能在植物房间的复杂依赖者的肌动朊聚合仍然保持不清楚。我们证明通常认为的疤建筑群子单元 BRK1 和 SCAR1 在扩展叶子和根的细胞对在细胞生长和墙免职的地点的血浆膜局部性。BRK1 本地化是疤依赖者,提供在在 vivo 的这些蛋白质之间的一个协会的进一步的证据。与疤建筑群子单元的血浆膜本地化一致,在根尖端房间的外皮的 F 肌动朊累积在 brk1 异种被减少。而且,破坏 SCAR 或 ARP2/3 建筑群的变化减少渗透半固体媒介的根和他们的能力的生长率,建议减少的刚硬。变异的根的房间墙在 BRK1 和 SCAR1 在邻近的血浆膜被充实的细胞间的连接展出反常结构和作文。一起拿,我们的结果建议复杂依赖者的肌动朊聚合支持的那个疤和 ARP2/3 在为正常生长和墙汇编是重要的血浆膜处理。 | Julia Dyachok Mon-Ray Shao Kevin Vaughn Andrew Bowling Michelle Facette Stevan Djakovic Lauren Clark Laurie Smith | 2008 | Molecular Plant2008，1，6： | 3 |
| 4 | Impact of RAS and BRAF mutations on carcinoembryonic antigen production and pattern of colorectal metastases显示文摘AIM: To investigate the impact of RAS and BRAF mutations on the pattern of metastatic disease and carcinoembryonic antigen(CEA) production.METHODS: In this retrospective study, we investigated the impact of RAS and BRAF mutational status on pattern of metastatic disease and CEA production. Only patients presenting with a newly diagnosed metastatic colorectal cancer(CRC) were included. Patients' characteristics, primary tumor location, site of metastatic disease and CEA at presentation were compared between those with and without RAS and BRAF mutations.RESULTS: Among 174 patients, mutations in KRAS, NRAS and BRAF were detected in 47%, 3% and 6% respectively. RAS mutations(KRAS and NRAS) were more likely to be found in African American patients(87% vs 13%; P value = 0.0158). RAS mutations were associated with a higher likelihood of a normal CEA(< 5 ng/mL) at presentation. BRAF mutations were more likely to occur in females. We were not able to confirm any association between mutational status and site of metastatic disease at initial diagnosis.CONCLUSION: No association was found between RAS and BRAF mutations and sites of metastatic disease at the time of initial diagnosis in our cohort. Patients with RAS mutations were more likely to present with CEA levels < 5 ng/mL. These findings may have clinical implications on surveillance strategies for RAS mutant patients with earlier stages of CRC. | may cho chie akiba cecilia lau david smith milhan telatar michelle afkhami stephen sentovich kurt melstrom marwan fakih | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 3 |
| 5 | Transcontinental Robot-Assisted Remote Telesurgery: Feasibility and Potential Applications显示文摘 | Jacques Marescaux Joel Leroy Francesco Rubino Michelle Smith Michel Vix Michele Simone Didier Mutter | 2002 | Annals of Surgery2002，，4： | 2 |
| 6 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 7 | Determination of benzene content in food using a novel blender purge and trap GC/MS method显示文摘 | BARSHICH S A SMITH S M MICHELLE V | 1995 | Journal of Food Composition and Analysis1995，25，8： | 1 |
| 8 | 锐钛型钛二氧化物纳米颗粒对小鼠的影响:证据表明短时间而不是长时间的暴露会导致小鼠精子结构和功能的异常显示文摘锐钛型钛二氧化物纳米颗粒(TNPs)广泛应用在商业领域,并且存在于不同的产品中。为明确更小剂量的锐钛型钛二氧化物纳米颗粒(ATNPs)间隔一定距离进入体内到达阴囊后是否能诱导精子缺陷的发生,雄性成年小鼠持续3天腹腔内注射100%ATNP(2.5或5mg/kg),然后在注射后1周、2周、3周或5周(长时间暴露)或者是注射后24小时、48小时或120小时(短时间暴露)处死。透射电镜表明在注射后120小时收集到的阴囊脂肪组织中,附睾组织和附睾液均出现炎症反应。在注射后120小时和3周后,睾丸组织间质间隙增大。利用末端脱氧核糖核酸转移酶介导的缺口末端标记技术发现在注射后的雄鼠体内阳性(即凋亡)精子(P=0.002)和间质细胞(P=O.04)数目均显著增加。与对照组相比,短时间暴露而不是长时间暴露的附睾尾部精子鞭毛异常、过量胞浆残余(ERC)的发生率增加,精子无顶体反应的发生率增加(呈剂量依赖性)。ERC与无顶体反应是否存在相关性目前尚不清楚。与对照组相比,暴露120小时组快速运动精子数量和线粒体膜电位均显著下降(P〈0.05),同时,活性氧水平显著增加(P〈0.00001)。这些结果表明在注射后4.8天,ANTP能够引发不育的精子结构和功能的异常,并且通过氧化应激造成DNA的损伤。同时,在暴露后的10天到5周末检测到精子的异常,这表明精子的这种异常是暂时性的。 | Michelle A Smith Rowan Michael Rolands G Aravindan Soma Dash Syed I Shah Deni S Galileo Patricia A Martin-DeLeon | 2015 | Asian Journal of Andrology2015，17，2： | 1 |
| 9 | Effect of environment on fatigue crack propagation behavior of alloy 718 at elevated temperatures显示文摘 | H. H. Smith D. J. Michel | 1986 | Metallurgical Transactions A1986，，2： | 1 |
| 10 | Multiple independent appearances of the cecal appendix in mammalian evolution and an investigation of related ecological and anatomical factors显示文摘 | Heather F. Smith William Parker Sanet H. Kotzé Michel Laurin | 2012 | Comptes rendus - Palevol2012，，： | 1 |
| 11 | Com-parison of transient and static test methods for chip-to-sink thermal interface characterization显示文摘 | SMITH B BRUNSCHWILER T MICHEL B | 2009 | Microelectronics Journal2009，40，： | 1 |
| 12 | Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model显示文摘 | Monica Gaidhane Ioana Smith Kristi Ellen Jeremy Gatesman Nagy Habib Patricia Foley Christopher Moskaluk Michel Kahaleh Salem Omar | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 13 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 14 | Prospective Randomized Comparison of Conventional Stress Echocardiography and Real-Time Perfusion Stress Echocardiography in Detecting Significant Coronary Artery Disease显示文摘 | Deepak Thomas Feng Xie Lynette M. Smith Edward O’Leary Kara Smith Joan Olson Kevin Nalty Roberta Hess Michelle Graham Stacey Therrien Thomas R. Porter | 2012 | Journal of the American Society of Echocardiography2012，，： | 1 |
| 15 | Tracking Moving Devices with the Cricket Location System 显示文摘 | Adam Smith Hari Balakrishnan Michel Goraczko Nissanka Bodhi Priyantha | 2004 | In: 2nd International Conference on Mobile Systems Applications and Services ( Mobisys 2004 ) Boston MA USA : ACM Press2004，2004，： | 1 |
| 16 | Internal Mammary Nodal Chain Drainage Is a Prognostic Indicator in Axillary Node-Positive Breast Cancer显示文摘 | Michelle S. Yao Brenda F. Kurland Anne H. Smith Erin K. Schubert Lisa K. Dunnwald David R. Byrd David A. Mankoff MD PhD | 2007 | Annals of Surgical Oncology2007，，10： | 1 |
| 17 | Managing intel- lectual property: a strategic point of view显示文摘 | MICHELE SMITH FREDERICK HANSEN | 2002 | Journal of Intel- lectual Capital2002，，34： | 1 |
| 18 | Novel approaches to combat chemoresistance against glioblastomas显示文摘The poor prognosis of glioblastoma multiforme(GBM)patients is in part due to resistance to current standard-of-care treatments including chemotherapy[predominantly temozolomide(TMZ;Temodar)],radiation therapy and an anti-angiogenic therapy[an antibody against the vascular endothelial growth factor(bevacizumab;Avastin)],resulting in recurrent tumors.Several recurrent GBM tumors are commonly resistant to either TMZ,radiation or bevacizumab,which contributes to the low survival rate for GBM patients.This review will focus on novel targets and therapeutic approaches that are currently being considered to combat GBM chemoresistance.One of these therapeutic options is a small molecule called OKlahoma Nitrone 007(OKN-007),which was discovered to inhibit the transforming growth factor β1 pathway,reduce TMZ-resistance and enhance TMZ-sensitivity.OKN-007 is currently an investigational new drug in clinical trials for both newly-diagnosed and recurrent GBM patients.Another novel target is ELTD1(epidermal growth factor,latrophilin and seven transmembrane domain-containing protein 1;alternatively known as ADGRL4,Adhesion G protein-coupled receptor L4),which we used a monoclonal antibody against,where a therapy against it was found to inhibit Notch 1 in a pre-clinical GBM xenograft model.Notch 1 is known to be associated with chemoresistance in GBM.Other potential therapeutic targets to combat GBM chemoresistance include the phosphoinositide 3-kinase pathway,nuclear factor-κB,the hepatocyte/scatter factor(c-MET),the epidermal growth factor receptor,and the tumor microenvironment. | Rheal A.Towner Michelle Zalles Debra Saunders Nataliya Smith | 2020 | Cancer Drug Resistance2020，3，4： | 1 |
| 19 | Structural and Functional Consequences of Mitochondrial Biogenesis in Human Adipocytes in Vitro显示文摘 | Iwona Bogacka Barbara Ukropcova Michele McNeil Jeffrey M. Gimble Steven R. Smith | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，12： | 1 |
| 20 | Colorimetfic method for determination of sugers and related substance显示文摘 | Michel D Gilles K A Fred Smith | 1956 | Anal Chem1956，28，3： | 1 |
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