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| 1 | T-cell ageing in end-stage renal disease patients:Assessment and clinical relevance显示文摘End-stage renal disease(ESRD) patients have a defective T-cell-mediated immune system which is related to excessive premature ageing of the T-cell compartment.This is likely to be caused by the uremia-associated pro-inflammatory milieu,created by loss of renal function.Therefore,ESRD patients are highly susceptible for infections,have an increased risk for virus-associated cancers,respond poorly to vaccination and have an increased risk for atherosclerotic diseases.Three ageing parameters can be used to assess an immunological T-cell age.First,thymic output can be determined by assessing the T-cell receptor excision circlescontent together with CD31 expression within the naive T cells.Second,the telomere length of T cells and third the T-cell differentiation status are also indicators of T-cell ageing.Analyses based on these parameters in ESRD patients revealed that the immunological T-cell age is increased by on average 20 years compared to the chronological age.After kidney transplantation(KTx) the aged T-cell phenotype persists although the pro-inflammatory milieu is diminished.This might be explained by epigenetic modifications at hematopoietic stem cells level.Assessment of an immunological T-cell age could be an important tool to identify KTx recipients who are at risk for allograft rejection or to prevent over-immunosuppression. | Ruud WJ Meijers Michiel GH Betjes Carla C Baan Nicolle HR Litjens | 2014 | World Journal of Nephrology2014，3，4： | 2 |
| 2 | Comparative study of pressure-induced germination of Bacillus subtilis spores at low and high pressure显示文摘 | WUYTACK E Y BOVEN S MICHIELS C W | 1998 | Applied and Environmental Microbiology1998，64，9： | 1 |
| 3 | Endothelial cell functions 显示文摘 | Michiels C | 2003 | J Cell Physiol2003，196，3： | 1 |
| 4 | Prediction of cancer outcome with microarrays: a multiple random validation strategy 显示文摘 | MICHIELS S KOSCIELNY S HILL C | 2005 | Lancet2005，365，9458： | 1 |
| 5 | Reciprocal influence of the p53 and the hy-poxic pathways显示文摘 | Sermeus A Michiels C | 2011 | Cell Death Dis2011，2，： | 1 |
| 6 | A study on the effects of high pressure and heat on Bacillus subtilis spores at low Ph显示文摘 | Wuytack E Y Michiels C W | 2001 | International Journal of Food Microbiology2001，64，： | 1 |
| 7 | Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes显示文摘 | Michiels C Minet E Mottet D | 2002 | Free Radic Biol Med2002，33，9： | 1 |
| 8 | Importance of the Glutathione Peroxidase, Catalase and Cu/Zn-SOD for Cell Survival against Oxidative Stress 显示文摘 | Michiels C Raes M Toussaaint O | 1994 | Free Radical Bio Med1994，17，： | 1 |
| 9 | Rapidquantification of pharmaceuticals and pesticides in passivesamplers using ultra high performance liquid chromatographycoupled to high resolution mass spectrometry 显示文摘 | KLAAS W MICHIEL C KAREN R | 2011 | JChromatogrA2011，1218，51： | 1 |
| 10 | Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-$ pathway that drives tumor angiogenesis 显示文摘 | Vegran F Boidot R Michiels C | 2011 | Cancer Res2011，71，7： | 1 |
| 11 | Antimicrobial properties of lysozyme in relation to foodborne vegetative bacteria显示文摘 | Masschalk B Michiels C W | 2003 | Critical Reviews in Microbiology2003，29，3： | 1 |
| 12 | Absence of internal ribosome entry site-mediated tissue specificity in the translation of a bicistronic transgene显示文摘 | Shaw - Jackson C Michiel T | 1999 | J Virol1999，73，4： | 1 |
| 13 | Endothelial cell responses to hypoxia:initiation of a cascade of cellular interactions显示文摘 | Michiels C Arnould T Remacle J | 2000 | Biochem Biophys Acta2000，1497，1： | 1 |
| 14 | Anti - cancer activities of pH - or heat - modified pectin 显示文摘 | Leclere L Cutsem P V Michiels C | 2013 | Frontiers in Pharmcacolo- gy2013，4，： | 1 |
| 15 | Comparison of the aneuploidy frequency in embryos derived from testicular sperm extraction in obstructive non-obstructive azooserpmic men显示文摘 | Platteau P Staessen C Michiel A | 2004 | Hum Reprod2004，19，7： | 1 |
| 16 | Increased PMN adherence on endothelial cells after hypoxia:involvement of PAF,CD18/CD11b,and ICAM-1显示文摘 | Arnould T Michiels C Remacle J | 1993 | Am J Physiol1993，264，51： | 1 |
| 17 | A study on the effects of high pressure and heat on Bacillus subtilis spores at low pH显示文摘 | WUYTACK E Y MICHIELS C W | 2001 | International Journal of Food Microbiology2001，64，3： | 1 |
| 18 | Different anthracycline derivates for reducing cardiotoxicity in cancer patients显示文摘 | van-Dalen E C Michiels E M Caron H N | 2006 | Cochrane Database Syst Rev2006，12，5： | 1 |
| 19 | Importance of seglutathione peroxidase,catalase and Cu/Zn-SOD for cell survival againts oxidative stress显示文摘 | Michiels C Raes M Toussaint O | | 0，，03： | 1 |
| 20 | Regulation of gene expression by oxygen: NF-Kappa B and HIF-1, two extremes显示文摘 | Michiels C Miner E Mottet D | 2002 | Free Radic Biol Med2002，33，9： | 1 |
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