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| 1 | Current status of diagnosis and treatment of hepatic echinococcosis显示文摘Echinococcus granulosus(E.granulosus) and Echinococcus multilocularis(E.multilocularis) infections are the most common parasitic diseases that affect the liver.The disease course is typically slow and the patients tend to remain asymptomatic for many years.Often the diagnosis is incidental.Right upper quadrant abdominal pain,hepatitis,cholangitis,and anaphylaxis due to dissemination of the cyst are the main presenting symptoms.Ultrasonography is important in diagnosis.The World Health Organization classification,based on ultrasonographic findings,is used for staging of the disease and treatment selection.In addition to the imaging methods,immunological investigations are used to support the diagnosis.The available treatment options for E.granulosus infection include open surgery,percutaneous interventions,and pharmacotherapy.Aggressive surgery is the first-choice treatment for E.multilocularis infection,while pharmacotherapy is used as an adjunct to surgery.Due to a paucity of clinical studies,empirical evidence on the treatment of E.granulosus and E.multilocularis infections is largely lacking;there are no prominent and widely accepted clinical algorithms yet.In this article,we review the diagnosis and treatment of E.granulosus and E.multilocularis infections in the light of recent evidence. | Memmet Mihmanli Ufuk Oguz Idiz Cemal Kaya Uygar Demir Ozgur Bostanci Sinan Omeroglu Emre Bozkurt | 2016 | World Journal of Hepatology2016，8，28： | 50 |
| 2 | Recent developments and innovations in gastric cancer显示文摘Gastric cancer has an important place in the worldwide incidence of cancer and cancer-related deaths. It can metastasize to the lymph nodes in the early stages, and lymph node metastasis is an important prognostic factor. Surgery is a very important part of gastric cancer treatment. A D2 lymphadenectomy is the standard surgical treatment for c T1N+ and T2-T4 cancers, which are potentially curable. Recently, the TNM classification system was reorganized, and the margins for gastrectomy and lymphadenectomy were revised. Endoscopic, laparoscopic and robotic treatments of gastric cancer have progressed rapidly with development of surgical instruments and techniques, especially in Eastern countries. Different endoscopic resection techniques have been identified, and these can be divided into two main categories: endoscopic mucosal resection and endoscopic submucosal dissection. Minimally invasive surgery has been reported to be safe and effective for early gastric cancer, and it can be successfully applied to advanced gastric cancer with increasing experience. Cytoreductive surgery and hypertherm?c intraper?toneal chemotherapy were developed as a combined treatment modality from the results of experimental and clinical studies. Also, hyperthermia increases the antitumor activity and penetration of chemotherapeutics. Trastuzumab which is a monoclonal antibody interacts with human epidermal growth factor(HER) 2 and is related to gastric carcinoma. The anti-tumor mechanism of trastuzumab is not clearly known, but mechanisms such as interruption of the HER2-mediated cell signaling pathways and cell cycle progression have been reported previously. H. pylori is involved in 90% of all gastric malignancies and Japanese guidelines strongly recommend that all H. pylori infections should be eradicated regardless of the associated disease. In this review, we present innovations discussed in recent studies. | Mehmet Mihmanli Enver Ilhan Ufuk Oguz Idiz Ali Alemdar Uygar Demir | 2016 | World Journal of Gastroenterology2016，22，17： | 29 |
| 3 | Delaying surgery after neoadjuvant chemoradiotherapy improves prognosis of rectal cancer显示文摘AIM To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy(CRT) and surgery in locally advanced rectal cancer.METHODS We evaluated 87 patients with locally advanced mid-or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at ?i?li Hamidiye Etfal Training and Research Hospital,Istanbul between January 2009 and January 2014.Patients were divided into two groups according to the intervalbefore surgery: < 8 wk(group Ⅰ) and ≥ 8 wk(group Ⅱ).Data related to patients,cancer characteristics and pathological examination were collected and analyzed.RESULTS When the distribution of timing between group Ⅰ(n = 45) and group Ⅱ(n = 42) was viewed,comparison of interval periods(median ± SD) of groups showed a significant difference of as 5 ± 1.28 wk in group Ⅰ and 10.1 ± 2.2 wk in group Ⅱ(P < 0.001).The median follow-up period for all patients was 34.5(9.9-81) mo.group Ⅱ had significantly higher rates of pathological complete response(p CR) than group Ⅰ had(19% vs 8.9%,P = 0.002).Rate of tumor regression grade(TRG) poor response was 44.4% in group Ⅰ and 9.5% in group Ⅱ(P < 0.002).A poor pathological response was associated with worse disease-free survival(P = 0.009).The interval time did not show any association with local recurrence(P = 0.79).CONCLUSION Delaying the neoadjuvant CRT-surgery interval may provide nodal down-staging,improve p CR rate,and decrease the rate of TRG poor response. | Mehmet Mihmanli Esin Kabul Gürbulak Ismail Ethem Akgün Mustafa Fevzi Celayir Pinar Yazici Deniz Tuncel Tuba Tülin Bek Ayhan Oz Sinan Omeroglu | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 4 | The risk of hypocalcemia in patients with parathyroid autotransplantation during thyroidectomy显示文摘 | Oran E Yetkin G Mihmanli M | 2016 | Ulusal cerrahi dergisi2016，32，1： | 1 |
| 5 | The use of tumor markers as predictors of prognosis in gastric cancer 显示文摘 | Mihmanli M Dilege E Demir U | 2004 | Hepato-gastroenterology2004，51，59： | 1 |
| 6 | Another face of mirror-image artifact显示文摘 | Cetinkaya S Kurugoglu S | 2001 | European Journal of Ultrasound2001，14，： | 1 |
| 7 | Prognostic value of preoperative CEA and CA 19-9 levels in resectable gastric cancer显示文摘 | Dilege E Mihmanli M Demir U | 2010 | Hepatogastroenterology2010，57，99100： | 1 |
| 8 | Cyclic voiding cys- touretrography without the use of fluoroscopic monitoring 显示文摘 | Kadioglu A Mihmanli I Kantarci F | 2006 | Eur J Radiol2006，57，1： | 1 |
| 9 | Follow-up of ex- traeranial vertebral artery stents with Doppler sonography 显示文摘 | Kantarci F Mihmanli I Albayram M S | 2006 | Am J Roentgenol2006，187，3： | 1 |
| 10 | Prognostic value of preoperative CEA and CA19-9 levels in resectable gastric cancer显示文摘 | Dilege E Mihmanli M Demir U | 2010 | Hepatogastroenterology2010，57，99100： | 1 |
| 11 | Color Doppler Analysis of Vertebral Arteries显示文摘 | Osman Kizilkilie Cem Hurean Ismail Mihmanli | 2002 | American Institute of Ultrasound in Medicine2002，23，： | 1 |
| 12 | The use of tumor markers as predictors of prognosis in gastric cancer 显示文摘 | Mihmanli M Dilege E Demir U | 2004 | Hepatogastroenterology2004，51，59： | 1 |
| 13 | Cephalic vein and hemodialysis fistula: surgeon's observation versus color Doppler ultrasonographic findings显示文摘 | Mihmanli I Besirli K Kurugoglu S | 2001 | J Ultrasound Med2001，20，： | 1 |
| 14 | Prognostic value of preoperative CEA and CA 19-9 levels in resectable gastric cancer 显示文摘 | Dilege E Mihmanli M Demir U | 2010 | Hepatogastroenterology2010，57，99100： | 1 |
| 15 | Prog- nostic value of preoperative CEA and CA 19-9 levels in resectable gastric cancer 显示文摘 | Dilege E Mihmanli M Demir U | 2010 | Hepato- gastroenterology2010，57，99100： | 1 |
| 16 | Prognostic value of preoperative CEA and CA 19-9 levels in reseetable gastric cancer显示文摘 | Dilege E Mihmanli M Demir U | 2010 | Hepatogastroenterology2010，57，99100： | 1 |
| 17 | Islak Follow-up of extracranial vertebral artery stenls with Doppler sonography显示文摘 | Kantarei F Mihmanli I Albayram MS | 2006 | Am J Roentgenol2006，187，3： | 1 |
| 18 | Prognostic value of preop- erative CEA and CA19-9 levels in resectable gastric cancer显示文摘 | Dilege E Mihmanli M Demir U | 2010 | Hepatogastroemerology2010，57，99100： | 1 |
| 19 | Multifocal skeletal tuberculosis显示文摘 | Yilmaz MH Kantarci F Mihmanli I | 2004 | South Med J2004，97，8： | 1 |
| 20 | Giant multiloeular eystadenoma of the prostate: a rare cause of huge cystic pelvic mass 显示文摘 | Olgun DC Onal B Mihmanli I | 2012 | Korean J Urol2012，53，3： | 1 |
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