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| 1 | 乳腺单纯型大汗腺癌代表一种独特的雄激素受体阳性的三阴型乳腺癌亚型显示文摘乳腺单纯型大汗腺癌在所有乳腺癌中不足1%,是一种胞质内富含嗜酸性颗粒,核圆形,核仁明显的乳腺癌,肿瘤ER、PR及HER-2均阴性,对基于激素和HER-2方案的化疗无效,因此通常被归为三阴型乳腺癌进行治疗,甚至部分病例接受强化化疗。但与其他类型三阴型乳腺癌不同的是,该亚型乳腺癌表达雄激素受体(AR)是大部分非大汗腺分化的三阴型乳腺癌(NA—TNC)所不具有的特征。因此AR可作为乳腺大汗腺癌的一个关键诊断标记及治疗靶点。 | Mills A M E Gottlieb C M Wendorth S 王婷 余英豪 | 2016 | 临床与实验病理学杂志2016，32，11： | 10 |
| 2 | 终末期肾病患者大血管和微血管内皮功能障碍与亚临床心功能不全的关系显示文摘终末期肾病(end-stagerenaldisease,ESRD)患者的心脏衰竭和心血管病死亡率较高,而我们对此缺乏深入透彻的了解,是否存在可变因素导致了这些高危患者发生心功能不全。为了评估血管内皮功能能否作为ESRD患者潜在的心功能不全的可变因素,研究人员应用横断面研究在一个控制良好的ESRD队列中,分析大血管和微血管功能障碍与左、右心功能不全的相关性。 | 刘莉 叶鹏 Dubin RF Guajardo I Ayer A Mills C Donovan C Beussink L Scherzer R Ganz P Shah SJ | 2016 | 中华高血压杂志2016，24，9： | 5 |
| 3 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 4 | Cellular targets in diabetic retinopathy therapy显示文摘Despite the existence of treatment for diabetes,inadequate metabolic control triggers the appearance of chronic complications such as diabetic retinopathy.Diabetic retinopathy is considered a multifactorial disease of complex etiology in which oxidative stress and low chronic inflammation play essential roles.Chronic exposure to hyperglycemia triggers a loss of redox balance that is critical for the appearance of neuronal and vascular damage during the development and progression of the disease.Current therapies for the treatment of diabetic retinopathy are used in advanced stages of the disease and are unable to reverse the retinal damage induced by hyperglycemia.The lack of effective therapies without side effects means there is an urgent need to identify an early action capable of preventing the development of the disease and its pathophysiological consequences in order to avoid loss of vision associated with diabetic retinopathy.Therefore,in this review we propose different therapeutic targets related to the modulation of the redox and inflammatory status that,potentially,can prevent the development and progression of the disease. | María Lucía Rodríguez Iván Millán Ángel Luis Ortega | 2021 | World Journal of Diabetes2021，12，9： | 3 |
| 5 | Presbycusis显示文摘 | George A Gates John H Mills | 2005 | The Lancet . 2005 (9491)2005，，9491： | 2 |
| 6 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 7 | Protein localization in living cells and tissues using FRET and FLIM显示文摘 | Chen Y Mills JD Periasamy A | 2003 | Differentiation2003，，910： | 2 |
| 8 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 9 | HPV E6/E7 mRNA原位杂交诊断宫颈低级别鳞状上皮内病变显示文摘宫颈低级别鳞状上皮内病变(LSIL)[亦称宫颈上皮内瘤变,1级(CIN1)]可带来相当大的诊断挑战,并且与观察者之间重复性较差和过诊断有关。此外,一些辅助性检测项目,如p16免疫组化检查在解析LSIL与正常/反应性鳞状上皮病变的差异作用不大。人类乳头状瘤病毒(HPV)RNA原位杂交(ISH)检测在LSIL的诊断中可能是一种较好的辅助诊断方法,但目前这方面尚没有较大宗病例的研究。 | 解建军 张仁亚 Mills A M Coppock J D Willis B C | 2018 | 临床与实验病理学杂志2018，34，11： | 2 |
| 10 | 显示文摘 | Mills A Hante Le | 1997 | J Photochem Photobiol A1997，108，： | 2 |
| 11 | 乳腺癌错配修复缺陷与PD-L1表达的关系显示文摘错配修复(MMR)缺陷最近被认为与PD-1/PD-L1免疫抑制疗法的敏感性有关。有研究证明,MMR蛋白缺失表达与直肠癌子宫内膜癌肿瘤组织中PDL-1表达存在一定的联系,但在乳腺癌中MMR蛋白与PD-L1表达之间的关系目前尚未见报道,因为乳腺癌中MMR表达缺失较少见。 | Mills A M Dill E A Moskaluk C A 卢菊萍(摘译) 余英豪(审校) | 2019 | 临床与实验病理学杂志2019，35，3： | 2 |
| 12 | Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: Evidence from 2 birth cohorts显示文摘 | Mill J Caspi A Williams BS | 2006 | Arch Gen Psychiatry2006，63，4： | 1 |
| 13 | Calpain activity in the rat brain after transient forebrain ischemia 显示文摘 | NEUMAR R W MENG F H MILLS A M | 2001 | Exp Neurol2001，170，1： | 1 |
| 14 | Nampt/PBEF/Visfatin regu-lates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme显示文摘 | Revollo JR K(o)rner A Mills KF | 2007 | Cell Metab2007，6，5： | 1 |
| 15 | Characterization of flavonoids in cranberry (Vaccinium macrocarpon) powder显示文摘 | VVEDENSKAYA I O ROSEN R T GUIDO J E RUSSELL D J MILLS K A VORSA N | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 16 | Vaccination of Pregnant Dams with Intimin O157 Protects Suckling Piglets from Escherichia coli O157: H7 Infection显示文摘 | Dean-Nystrom E A Gansheroff L J Mills M | 2002 | Infect Immun2002，70，： | 1 |
| 17 | An overview of semiconductor photocatalisis 显示文摘 | Mills A Lehunte S | 1997 | J Photochem Photobiol A : Chem1997，108，1： | 1 |
| 18 | Houdriforming reactions catalytic mechanism显示文摘 | MILLS G A HEINEMANN H MILLIKEN T H OBLAD A G | 1953 | Ind Eng Chem1953，45，： | 1 |
| 19 | Salinity inhibits post transcriptional processing of chloroplast 16S rRNA in shoot cultures of jojoba(Simmondsia chinesis)显示文摘 | Mizrahi-Aviv E Mills D Benzioni A | 2005 | Plant Cell Rep2005，23，1011： | 1 |
| 20 | Collapse of a fish population after exposure to a synthetic estrogen 显示文摘 | KIDD K A BLANCHFIELD P J MILLS K H | 2007 | Pro- ceedings of the National Academy Science2007，104，21： | 1 |
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