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| 1 | 抑制平滑肌的张力收缩:一种治疗勃起功能障碍的新途径显示文摘阴茎海绵体血管的收缩及张力的维持是由钙敏感的RhoA/Rho激酶信号传导途径介导的。以Y 2 76 32抑制海绵体平滑肌细胞的Rho激酶信号系统可促进阴茎勃起 ,表现为海绵体内压 (ICP)明显升高 ,而平均动脉压 (MAP)变化不显著。为什么在血管收缩信号很强的情况下性刺激仍能引发阴茎勃起反应 ?我们设想体内一氧化氮 (NO)能直接抑制RhoA/Rho激酶途径的活性 ,减少血管张力 ,促使血管舒张 ,勃起发生 ,使用Y 2 76 32可以恢复性腺功能低下和高血压病动物ED模型的阴茎勃起功能 ,这表明抑制Rho激酶活性药物具有临床应用的前景。此外 ,我们的结果显示阴茎表面使用Rho激酶抑制剂可能为ED治疗的有效方法之一。 | 戴玉田 Thomas M MILLS Ronald W LEWIS RClinton WEBB | 2002 | 中华男科学杂志2002，8，6： | 8 |
| 2 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 3 | A proposal for an international nomenclature of races of Phytophthora infestans and of genes controlling immunity in Solanum demissum derivaties 显示文摘 | Black W Mastenbrock C Mills W R | 1953 | Enphytica1953，2，3： | 1 |
| 4 | Calpain activity in the rat brain after transient forebrain ischemia 显示文摘 | NEUMAR R W MENG F H MILLS A M | 2001 | Exp Neurol2001，170，1： | 1 |
| 5 | Conformal dome correction with counterrotating phase plates 显示文摘 | SPARROLD S W Mills J P Knapp D J et at | 2000 | Opt Eng2000，39，： | 1 |
| 6 | Dynamic Finite-element Analysis of a Planar High-speed, High-precision Parallel Manipulator with Flexible Links 显示文摘 | Gabriel P Cleghorn W L Mills J K | 2005 | Mechanism and Machine Theory (S0094-114X)2005，40，7： | 1 |
| 7 | The emerging role of lysophosphatidic acid in cancer 显示文摘 | Mills G B Moolenaar W H | 2003 | Nat Rev Cancer2003，3，8： | 1 |
| 8 | Predominance of the ae variant in K88-positive Escherichia coli isolates from swine 显示文摘 | Westerman B Mills W Phillips M | 1988 | Clin Microbiol1988，26，： | 1 |
| 9 | Dynamic modeling and experimental validation of a 3 - PRR parallel manipulator with flexible intermediate links 显示文摘 | Zhang X Mills J K Cleghorn W L | 2007 | Journal of Intelligent and Robotic Systems2007，50，4： | 1 |
| 10 | Review and synthesis of stress intensity factor solution applied to cracks in bolts 显示文摘 | James L A Mills W J | 1988 | Engineering Fracture Mech1988，30，： | 1 |
| 11 | Theory of electron-avalanche breakdown in solid显示文摘 | Sparks M Mills D L Holstein R W T | 1981 | Phys Rev B1981，24，6： | 1 |
| 12 | Predictions of potential human health and ecological risk from power plant discharges of total residual chlorine and chloroform into rivers 显示文摘 | MILLS W B LEW C S LOH J Y | 1998 | Environ Sci Technol1998，32，14： | 1 |
| 13 | Dynamic finite-element analysis of a planar high-speed, high-precision parallel manipulator with flexible links显示文摘 | PIRAS G CLEGHORN W L MILLS J K | 2005 | Mechanism and Machine Theory2005，40，7： | 1 |
| 14 | Experimental implementation on vibration mode control of a moving 3 - PRR flexible parallel manipulator with multiple PZT transducers显示文摘 | Zhang X Mills J K Cleghorn W L | 2010 | Journal of Vibration and Control2010，16，13： | 1 |
| 15 | Urinary diversion 显示文摘 | World Health Organization (WHO) Conference in Bladder Cancer Hautmann RE Abol-Enein H Hafez K Haro I Mansson W Mills RD Montie JD Sagalowsky AI Stein JP Stenzl A Studer UE Volkmer BG | 2007 | Urology2007，，： | 1 |
| 16 | Composition and quality of 'Braeburn' apples under reduced irrigation显示文摘 | Kilili A W Behboudian M H Mills T M | 1996 | Scientia Horticulturae1996，67，： | 1 |
| 17 | A proposal for an international nomenclature of races of Phytophthora infestans and of genes controlling immuunity in Solanum demissum derivaties显示文摘 | Black W Mastenbrock C Mills W R | 1953 | Enphytica1953，2，3： | 1 |
| 18 | Experimen tal Investigation of Heat Transfer in Grinding显示文摘 | Rowe W B Black S C E Mills B | 1995 | CIRP Annals- Manufacturing Technology1995，44，1： | 1 |
| 19 | Temperature Control in cBN Grinding显示文摘 | Rowe W B Black S C E Mills B | 1996 | Advanced Manufaeturing Technology1996，，12： | 1 |
| 20 | Development and validation of a quality-of-life measure for men with nocturia显示文摘 | Abraham L Hareendran A Mills I W | 2004 | Urology2004，63，3： | 1 |
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