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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Eatimation of the Brooks-Corey parameters from water retonfion data显示文摘 | MILLY P C D | 1987 | Water Resource Research1987，23，： | 1 |
| 3 | Using absorbance and fluorescence spectra to discriminate microalage 显示文摘 | Millie D F Schofield O M Kirkpatryck G J | 2002 | European Journal of Phycology2002，37，3： | 1 |
| 4 | Detection of harmful algal blooms using photopigments and absorption signatures: A case study of the florida red tide dinoflagellate, Gymnodinium Breve 显示文摘 | Millie D F Schofield O M Kirkpatryck G J | 1997 | Limnology and Oceanography1997，42，5： | 1 |
| 5 | Crustal displacements due to continental water loading显示文摘 | Van Dam T Wahr J Milly P C D | 2001 | Geophysical Research Letters2001，28，4： | 1 |
| 6 | A simulation analysis of thermal effects on evaporation from soil显示文摘 | Milly P C D | 1984 | Water Resources Research1984，20，8： | 1 |
| 7 | Global pattern of trends in streamflow and water availability in a chang-ing climate显示文摘 | Milly P C C D Dunne K A Vecchia A V | 2005 | Nature2005，438，： | 1 |
| 8 | Global pattern of trends in streamflow and water availability in a chan- ging climate显示文摘 | Milly P C D Dunne K A Vecchia A V | 2005 | Nature2005，438，7066： | 1 |
| 9 | Increasing risk of great floods in a changing climate 显示文摘 | Milly P C D Wetherald R T Dunne K A | 2002 | Nature2002，415，： | 1 |
| 10 | Advances in modeling of water in the unsaturated zone显示文摘 | Milly C D | 1988 | Transport in Porous Media1988，18，3： | 1 |
| 11 | Moisture and heat transport in hysteretic, in homogeneous porous media: A matric head-based formulation and a numerical model 显示文摘 | Milly C P D | 1982 | Water Resources Res1982，18，3： | 1 |
| 12 | Bubble-size Distributions and Flow Fields in Bubble Columns 显示文摘 | Lehr F Millies M Mewes D | 2002 | Fluid Mechanics and TransportPhenomena2002，48，11： | 1 |
| 13 | Detection of harmful algal blooms using photopigments and absorption signatures:a case study of the Florida red tide dinoflagellate,Gymnodinium breve显示文摘 | MILLIE D F SCHOFIELD O M KIRKPATRICK G J | 1997 | Limnology and Oceanography1997，42，5： | 1 |
| 14 | Molecular profiling of infiltrating urothelial carcinoma of bladder and nonblad- der origin 显示文摘 | Millis SZ Bryant D Basu G | 2015 | Clin Genitonrin Cancer2015，13，1： | 1 |
| 15 | Potential evaporation and soil moisture in general circulation modles显示文摘 | Milly P C D | 1992 | Journal of climate1992，5，3： | 1 |
| 16 | Using absorbance and fluorescence spectra to discriminate microalgae显示文摘 | MILLIE D F SCHOFIELD O M E KIRKPATRICK G J | 2002 | European Journal of Phycology2002，37，： | 1 |
| 17 | Open reduction and internal fixation for supracondylar humerus fractures in children显示文摘 | Reitman R D Waters P Millis M | 2001 | J Pe-diatr Orthop2001，21，2： | 1 |
| 18 | Gravity changes due to continental water storage显示文摘 | Van Dam T Wahr J Milly P C D | 2001 | Journal of Geodetic Society of Japan2001，47，1： | 1 |
| 19 | Variants in the plasmacytoma variant translocation gene (PVT1) are asso- ciated with end-stage renal disease attributed to type 1 dia- betes 显示文摘 | Millis MP Bowen D Kingsley C | 2007 | Diabetes2007，56，12： | 1 |
| 20 | Global pattern of trends in streamflow and water availability in a changing climate显示文摘 | Milly P C C D Dunne K A Vecchia A V | 2005 | Nature2005，438，： | 1 |
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