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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Use of the tumor necrosis factor-blockers for Crohn's disease显示文摘The use of anti-tumor necrosis factor-therapy for inflammatory bowel disease represents the most important advance in the care of these patients since the publication of the National Co-operative Crohn's disease study thirty years ago.The recommendations of numerous consensus groups worldwide are now supported by a wealth of clinical trials and several meta-analyses.In general,it is suggested that tumor necrosis factor-blockers(TNFBs) are indicated(1) for persons with moderately-severe Crohn's disease or ulcerative colitis(UC) who have failed two or more causes of glucocorticosteroids and an acceptably long cause(8 wk to 12 wk) of an immune modulator such as azathioprine or methotrexate;(2) non-responsive perianal disease;and(3) severe UC not responding to a 3-d to 5-d course of steroids.Once TNFBs have been introduced and the patient is responsive,therapy given by the IV and SC rate must be continued.It remains open to definitive evidence if concomitant immune modulators are required with TNFB maintenance therapy,and when or if TNFB may be weaned and discontinued.The supportive evidence from a single study on the role of early versus later introduction of TNFB in the course of a patient's illness needs to be confirmed.The risk/benefit profile of TNFB appears to be acceptable as long as the patient is immunized and tested for tuberculosis and viral hepatitis before the initiation of TNFB,and as long as the long-term adverse effects on the development of lymphoma and other tumors do not prone to be problematic.Because the rates of benefits to TNFB are modest from a population perspective and the cost of therapy is very high,the ultimate application of use of TNFBs will likely be established by cost/benefit studies. | Alan BR Thomson Milli Gupta Hugh J Freeman | 2012 | World Journal of Gastroenterology2012，18，35： | 3 |
| 3 | Fermi-liquid-to-polaron crossover Ⅱ double exchange and the physics of colossal magnetoresistance 显示文摘 | Millis A J Mueller R Shraiman B I | 1996 | Phys Rev B1996，54，： | 2 |
| 4 | Effects of Magnetic Ordering on the Anisotropy and Temperature Dependence of the Optical Conductivity in LaMnO3: A Tight-Binding Approach 显示文摘 | Ahn K H Millis A J | 2000 | Phys Rev2000，61，12： | 2 |
| 5 | Double exchange alone does not explain the resistivity of La1-xSrxMnO3 phys 显示文摘 | Millis A J Littlewood P B Shraiman B I | 1995 | Rev Lett1995，74，： | 2 |
| 6 | Using absorbance and fluorescence spectra to discriminate microalage 显示文摘 | Millie D F Schofield O M Kirkpatryck G J | 2002 | European Journal of Phycology2002，37，3： | 1 |
| 7 | 显示文摘 | Millis A J Boris I Shraiman Mueller R | 1996 | Phys Rev Lett1996，77，： | 1 |
| 8 | Detection of harmful algal blooms using photopigments and absorption signatures: A case study of the florida red tide dinoflagellate, Gymnodinium Breve 显示文摘 | Millie D F Schofield O M Kirkpatryck G J | 1997 | Limnology and Oceanography1997，42，5： | 1 |
| 9 | Double exchange does not explain the resistivity of Lal-x SrxMnO3显示文摘 | Millis A J Littlewood P B Shraiman B I | 1995 | Phys Rev Lett1995，74，： | 1 |
| 10 | Crustal displacements due to continental water loading显示文摘 | Van Dam T Wahr J Milly P C D | 2001 | Geophysical Research Letters2001，28，4： | 1 |
| 11 | Stationarity is dead: Whither water management?显示文摘 | Milly P Betancourt J Falkenmark M | 2008 | Science2008，319，5863： | 1 |
| 12 | Randomized controlled trial to evaluate flush and reperfusion techniques in liver transplantation 显示文摘 | Millis J M Melinek J Csete M | 1997 | Transplantation1997，63，3： | 1 |
| 13 | Government policy and organ trans- plantation in China 显示文摘 | Huang J Mao Y Millis JM | 2008 | Lancet2008，372，： | 1 |
| 14 | A pilot pro- gramme of organ donation after cardiac death in China显示文摘 | Huang J Millis JM Mao Y | 2012 | Lancet2012，379，9818： | 1 |
| 15 | Advances in the physics of high-temperature superconductivity显示文摘 | Orenstein J Millis A J | 2000 | Science2000，288，5521： | 1 |
| 16 | Calorie and protein intake in acute rehabilitation inpatients with trau- matic spinal cord injury versus other diagnoses 显示文摘 | PELLICANE A J MILLIS SR ZIMMERMAN SE | 2013 | Topics in Spinal Cord Injury Rehabilitation2013，19，3： | 1 |
| 17 | Detection of harmful algal blooms using photopigments and absorption signatures:a case study of the Florida red tide dinoflagellate,Gymnodinium breve显示文摘 | MILLIE D F SCHOFIELD O M KIRKPATRICK G J | 1997 | Limnology and Oceanography1997，42，5： | 1 |
| 18 | Double exchange alone does not explain the resistiVity of Latex SrxMnO3 显示文摘 | Millis A J Littlewood P B Shraiman B J | 1995 | Phys Rev Lett1995，74，51： | 1 |
| 19 | Advances in the physics of hightemperature superconductivity 显示文摘 | ORENSTEIN J MILLIS A J | 2000 | Science2000，288，： | 1 |
| 20 | Using absorbance and fluorescence spectra to discriminate microalgae显示文摘 | MILLIE D F SCHOFIELD O M E KIRKPATRICK G J | 2002 | European Journal of Phycology2002，37，： | 1 |
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