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| 1 | Mechanism of diarrhea in microscopic colitis显示文摘AIM: To search the pathophysiological mechanism of diarrhea based on daily stool weights, fecal electrolytes,osmotic gap and pH.METHODS: Seventy-six patients were included: 51 with microscopic colitis (MC) [40 with lymphocytic colitis (LC);11 with collagenous colitis (CC)]; 7 with MC without diarrhea and 18 as a control group (CG). They collected stool for 3 d. Sodium and potassium concentration were determined by flame photometry and chloride concentration by titration method of Schales. Fecal osmotic gap was calculated from the difference of osmolarity of fecal fluid and double sum of sodium and potassium concentration.RESULTS: Fecal fluid sodium concentration was significantly increased in LC 58.11±5.38 mmol/L (P<0.01)and CC 54.14±8.42 mmol/L (P<0.05) than in CG 34.28±2.98 mmol/L. Potassium concentration in LC 74.65±5.29 mmol/L (P<0.01) and CC 75.53±8.78 mmol/L (P<0.05) was significantly less compared to CG 92.67±2.99 mmol/L.Chloride concentration in CC 36.07±7.29 mmol/L was significantly higher than in CG 24.11±2.05 mmol/L (P<0.05).Forty-four (86.7%) patients had a secretory diarrhea compared to fecal osmotic gap. Seven (13.3%) patients had osmotic diarrhea.CONCLUSION: Diarrhea in MC mostly belongs to the secretory type. The major pathophysiological mechanism in LC could be explained by a decrease of active sodium absorption. In CC, decreased Cl/HCO3 exchange rate and increased chloride secretion are coexistent pathways. | Marijana Protic Njegica Jojic Daniela Bojic Svetlana Milutinovic Dusanka Necic Bozidar Bojic Petar Svorcan Miodrag Krstic Obren Popovic | 2005 | World Journal of Gastroenterology2005，11，35： | 5 |
| 2 | Biochemical markers for non-invasive assessment of disease stage in patients with primary biliary cirrhosis显示文摘AIM: To evaluate different biochemical markers and their ratios in the assessment of primary biliary cirrhosis (PBC) stages. METHODS: This study included 112 patients with PBC who underwent a complete clinical investigation. We analyzed the correlation (Spearman's test) between ten biochemical markers and their ratios with different stages of PBC. The discriminative values were compared using areas under receiver operating characteristic (ROC) curves. RESULTS: The mean age of patients included in the study was 53.88 ± 10.59 years, including 104 females and 8 males. We found a statistically significant correlation between PBC stage and Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) to platelet ratio (APRI), ALT/platelet count, AST/ALT, ALT/AST and ALT/Cholesterol ratios, with the values of Spearman's rho of 0.338, 0.476, 0.404, 0.356, 0.351 and 0.325, respectively. The best sensitivity and specificity was shown for AST/ALT, with an area under ROC of 0.660. CONCLUSION: Biochemical markers and their ratios do correlate with different sensitivity to and specificity of PBC disease stage. The use of biochemical markers and their ratios in clinical evaluation of PBC patients may reduce, but not eliminate, the need for liver biopsy. | Tamara Alempijevic Miodrag Krstic Rada Jesic Ivan Jovanovic Aleksandra Sokic Milutinovic Nada Kovacevic Slobodan Krstic Dragan Popovic | 2009 | World Journal of Gastroenterology2009，15，5： | 4 |
| 3 | Investigation of the influence of oil injection upon the screw compressor working process 显示文摘 | Stosi N Milutinovic L Hanjalic K | 1992 | International Journal of Refrigeration1992，15，4： | 2 |
| 4 | How does DNA methyltrans2 ferase cause oncogenic transformation显示文摘 | SzyfM Knox DJ Milutinovic S | 2000 | Ann N YAcad Sci2000，910，： | 1 |
| 5 | An overview of reflective memory systems显示文摘 | Milan Jovanovic Veljko Milutinovic | 1999 | IEEE Parallel & Distributed Technology1999，7，2： | 1 |
| 6 | DNA methyltransferase inhi2 bition induces the transcription of the tumor supp ressor p21(WAF1/CIP1/sdi1)显示文摘 | Milutinovic S Knox JD SzyfM | 2000 | J Biol Chem2000，275，： | 1 |
| 7 | Continuing education of paediatricnurses in Vojvodina,Serbia Original Research Article显示文摘 | Brestovacki B Milutinovic D | 2011 | NurseEducation Today2011，31，5： | 1 |
| 8 | Plasma fibfinogen concentration predict the risk of myocardial infarction differently in varions parts of Europe:effects of 13-Fibfinogen genotype and environmental faetoys 显示文摘 | Poglajien G Kirbis J Milutinovic A | 2004 | Thromb Haemost2004，92，6： | 1 |
| 9 | DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21WAF1显示文摘 | Milutinovic S Knox JD Szyf M | 2000 | J Biol Chem2000，275，9： | 1 |
| 10 | An over- view of reflective memory systems显示文摘 | JOVANOVIC M MILUTINOVIC V | 1999 | Concur- rency1999，7，2： | 1 |
| 11 | Multifocal localization of tumors of Schwann cell origin显示文摘 | Milutinovic Z Vidojevic M Trifkovic Z | 2001 | Srp Arh Celok Lek2001，129，910： | 1 |
| 12 | Specific en-hancement of sarcomeric response to Ca2+ protects murine my-ocardium against ischemia-reperfusion dysfunction 显示文摘 | Arteaga GM Warren CM Milutinovic S | 2005 | Am JPhysiol Heart Circ Physiol2005，289，5： | 1 |
| 13 | Liver cysts in patients with autosomal dominant polycystic kidney disease 显示文摘 | Milutinovic J Fialkow PJ Rudd TG | 1980 | Am J Med1980，68，2： | 1 |
| 14 | Cardiac nitric ox- ide synthases and Na+/K+-ATPase in the rat model of polyeystic ovary syndrome induced by dihydrotestosterone显示文摘 | Tepavcevic S Milutinovic DV Macut D | 2015 | Exp Clin En- docrinol Diabetes2015，123，5： | 1 |
| 15 | An Overview of Retlective Mcmory Systems显示文摘 | Jovanovic M Milutinovic V | 1999 | IEEE Parallel & Distributed Technology1999，7，2： | 1 |
| 16 | Nephrotoxic effects of chronic administration of mierocystins-LR and-YR 显示文摘 | Milutinovic A Zivin M Zorc-Pleskovic R | 2003 | Toxicon2003，42，： | 1 |
| 17 | A postmortem analysis of major causes of early death in patients hospitalized with COPD exacerbation显示文摘 | Zvezdin B Milutinov S Kojicic M | 2009 | Chest2009，136，2： | 1 |
| 18 | DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21 WAF1/CIP1/ sdil 显示文摘 | Milutinovic S Knox JD Szyf M | 2000 | J Biol Chem2000，275，9： | 1 |
| 19 | DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21wAF1/CIP1/sdil显示文摘 | Milutinovic S Knox JD Szyf M | | 0，，： | 1 |
| 20 | clAP1 and clAP2 facilitate cancer cell survival by functioning as E3 ligases that pro- mote RIP1 ubiquitination 显示文摘 | Bertrand MJ Milutinovic S Dickson KM | 2008 | Mol Cell2008，30，6： | 1 |
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