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| 1 | Hepatocyte transplantation program:Lessons learned andfuture strategies显示文摘This review aims to share the lessons we learned over time during the setting of the hepatocyte transplantation(HT) program at the Hepatic Cell Therapy Unit at Hospital La Fe in Valencia. New sources of liver tissue for hepatocyte isolation have been explored. The hepatocyte isolation and cryopreservation procedures have been optimized and quality criteria for assessment of functionality of hepatocyte preparations and suitability for HT have been established. The results indicate that:(1) Only highly viable and functional hepatocytes allow to recover those functions lacking in the native liver;(2) Organs with steatosis(≥ 40%) and from elderly donors are declined since low hepatocyte yields, viability and cell survival after cryopreservation, are obtained;(3) Neonatal hepatocytes are cryopreserved without significant loss of viability or function representing high-quality cells to improve human HT;(4) Cryopreservation has the advantage of providing hepatocytes constantly available and of allowing the quality evaluation and suitability for transplantation; and(5) Our results from 5 adults with acute liver failure and 4 from children with inborn metabolic diseases, indicate that HT could be a veryuseful and safe cell therapy, as long as viable and metabolically functional human hepatocytes are used. | Eugenia Pareja Ibars Miriam Cortes Laia Tolosa Maria JoséGómez-Lechón Slivia López JoséVicente Castell JoséMir | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 2 | Effect of Calcineurin Inhibitors in the Outcome of Liver Transplantation in Hepatitis C Virus-Positive Recipients显示文摘 | Marina Berenguer Victoria Aguilera Fernando San Juan Salvador Benlloch Angel Rubin Rafael López-Andujar Angel Moya Eugenia Pareja Eva Montalva Maria Yago Manuel de Juan José Mir Martín Prieto | 2010 | Transplantation2010，，11： | 3 |
| 3 | Effect of dietary supplementation with either conjugated linoleic acid(CLA)or linoleic acid rich oil on the CLA content of lamb tissues显示文摘 | Mir Z Rushfeldt M L Mir P S | 2000 | Small Rum Res2000，36，： | 1 |
| 4 | Liver transplantation in patients with portal vein thrombosis显示文摘 | Gerardo Manzanet Fernando Sanjuán Paco Orbis Rafael López ángel Moya Manuel Juan Juanjo Vila Josep Asensi Pedro Sendra José Ru??z Mart??n Prieto José Mir | 2001 | Liver Transplantation2001，，2： | 1 |
| 5 | A simple HPL C-UV method for the simultaneous quantification of gefitinib and erlotinib in human plasma 显示文摘 | FAIVRE L GOMO C MIR O | 2011 | J Chromatogr B Analyt Technol Biomed Life Sci2011，879，23： | 1 |
| 6 | Vascular Complications After Orthotopic Liver Transplantation: Hepatic Artery Thrombosis显示文摘 | E. Pareja M. Cortes R. Navarro F. Sanjuan R. López J. Mir | 2010 | Transplantation Proceedings2010，，8： | 1 |
| 7 | Tissue ablation with irreversible eleetroporation显示文摘 | Davalos R V Mir L M Rubinsky B | 2005 | Annals of Biomedical Engineering2005，33，2： | 1 |
| 8 | A simple HPLC-UV method for the simultaneous quantification of gefitinib and erlotinib in human plasma显示文摘 | Faivre L Gomo C Mir O | 2011 | J Chromatogr B Analyt Technol Biomed Life Sci2011，879，23： | 1 |
| 9 | Use of array comparative ge- nomic hybridization (array-CGH) for embryo assessment: clin- ical results显示文摘 | Rubio C Rodrigo L Mir P | 2013 | Fertil Steril2013，99，4： | 1 |
| 10 | Preparation and characterization of n-type conductive (A1, Co) co-doped ZnO thin films deposited by sputtering from aerogel nanopowders 显示文摘 | Mir L E Ayadi Z B Saadoun M | 2007 | Appl Surf Sci2007，254，： | 1 |
| 11 | Preparation and optical characterization of transparent,microporous TiO2 xerogel monoliths显示文摘 | El Mir L Amlouk A Elaloui E | 2008 | Mater Sci Engn B2008，146，： | 1 |
| 12 | TEM, XRD and AFM study of poly (o-ethoxyaniline) films : new evidence for the formation of conducting islands 显示文摘 | Leite F L Alves WF Mir M | 2008 | Applied Physics A2008，，93： | 1 |
| 13 | Introduction of definite amounts of nonpermeant molecules into living cells after eleetropermeabilization, direct access to the eytosol显示文摘 | MIR L M BANOUN H PAOLETT C | 1988 | Exp Cell Res1988，175，1： | 1 |
| 14 | Therapeutic perspectives of in vivo cell electropermeailization显示文摘 | MIR L M | 2001 | Bioelectrocheraistry2001，53，1： | 1 |
| 15 | A simple I-Ir'LtS-UV memoo for the simultaneous quantification of gefitinib and erlotinib in human plasmas显示文摘 | Faivre L Gomo C Mir O | 2011 | Journal of Chromatography B2011，879，23： | 1 |
| 16 | Bleomycin:revieal of an old drug显示文摘 | Mir L M Tounekti O Orlowski S | 1996 | Gen Parmacol1996，27，5： | 1 |
| 17 | Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation 显示文摘 | Mir M Tolosa L Asensio V J | 2008 | J Neuroimmunol2008，204，12： | 1 |
| 18 | Influence of aging factors on the furanic aldehyde contents of matured brandies:aging markers显示文摘 | Quesada Granados J Villalón Mir M Garcia-Serrana L | 1996 | J Agr Food Chem1996，44，： | 1 |
| 19 | TEM, XRD and AFM study of poly ( o - ethoxyaniline) films : new evidence for the formation of conducting islands 显示文摘 | LEITE F L ALVES W F MIR M | 2008 | ApplPhys A2008，93，： | 1 |
| 20 | Electrochemotherapy,a new antitumor treatment:first clinical trial显示文摘 | Belehradek M Domenge C | 1991 | C R Acad Sci Ⅲ1991，313，13： | 1 |
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