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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | Graft copolymerization of 4-vinylpyridine and methyl acrylate onto polyethylene film by radiochemical method显示文摘 | MISRA B N GUPTA A | 1998 | J Appl Polym Sci1998，69，： | 1 |
| 3 | Least square estimation of three parameters of a weibull estimation显示文摘 | SOMAN K P MISRA K B | 1992 | Microelectronics and Reliability1992，32，3： | 1 |
| 4 | Changes in nucleic acids and protein content of Tilapia mossambica exposed to dichlorvos显示文摘 | Rath S Misra B N | 1980 | Indian Journal of Fisheries1980，27，： | 1 |
| 5 | Grafting:A versatile means to modify polymers Techniques,factors and applications显示文摘 | BHATTACHARYA A MISRA B N | 2004 | Progress in Polymer Science2004，29，： | 1 |
| 6 | Development of spray dried liposomal dry powder inhaler of Dapsone显示文摘 | Chougule M Padhi B Misra A | 2008 | AAPS PharmSciTech2008，9，1： | 1 |
| 7 | An Analysis of Generalized Slotted-Aloha Protocols 显示文摘 | Ma R T B Misra V Rubenstein D | 2009 | IEEE/ACM Transactions on Net- working2009，17，3： | 1 |
| 8 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 9 | Effect of long term administration of dietaryβ-glucan on immunity, growth and survival of Labeo rohita fingerlings显示文摘 | Misra C K Das B K Mukherjee S C Pattnaik P | 2006 | Aquaculture2006，255，： | 1 |
| 10 | Extraction of molybdenum from spent catalyst by salt-roasting 显示文摘 | Kar B B Murthy B V R Misra V N | 2005 | In- ternational Journal of Mineral Processing2005，76，3： | 1 |
| 11 | Nano-liposomal dry powder inhaler of tacrolimus: preparation, characterization, and pulmonary pharmacokinetics 显示文摘 | Chougule M Padhi B Misra A | 2007 | lnt JNanomedicine2007，2，4： | 1 |
| 12 | Least Square Estimation of Three Parame-ters of a Weibull Estimation显示文摘 | Soman K P Misra K B | 1992 | Microelectronics and Reliability1992，32，3： | 1 |
| 13 | Enhanced antibacterieidal func- tion of W4 -doped titania-coated nickel ferrite compositenanoparticles : a biomaterial system 显示文摘 | Sunkara B K Misra R D K | 2008 | Acta Biomaterialia2008，2，4： | 1 |
| 14 | An overview ofutilization of slag and sludge from steel industries 显示文摘 | Das B Prakash S Reddy P S R Misra V N | 2007 | Resources Conservation and Recycling2007，50，1： | 1 |
| 15 | Characterization of wool graft copolymers 显示文摘 | MISRA B N MEHTA I K SOOD D S | 1987 | J Appl Polym Sci1987，34，1： | 1 |
| 16 | A new geometric programming formulation for a reliability problem显示文摘 | Misra K B Sharma J | 1973 | International Journal Control1973，18，： | 1 |
| 17 | Remote Raman and fluorescence studies of mineral samples显示文摘 | Bozlee B J Misra A K | 2005 | Spectrochimica Acta Part A2005，，61： | 1 |
| 18 | Modeling and analysis of effects of awareness programs by media on the spread of infectious diseases 显示文摘 | Misra A K Sharma Anupama Shukla J B | 2011 | Mathematical & Computer Modelling2011，53，56： | 1 |
| 19 | Percutaneous management of bile duct strictures and injuries associated with laparoscopic cholecystectomy: a decade of experience显示文摘 | Sanjay Misra Genevieve B Melton J.F Geschwind Anthony C Venbrux John L Cameron Keith D Lillemoe | 2004 | Journal of the American College of Surgeons2004，，2： | 1 |
| 20 | Sigmoid colonic Wstula secondary to PerWx-plug, left inguinal erria repair显示文摘 | Murphy JW Misra DC Silverglide B | 2006 | Hernia2006，10，： | 1 |
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