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| 1 | Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy显示文摘AIM To compare the efficacy and safety of cold snare polypectomy(CSP) and hot forceps biopsy(HFB) for diminutive colorectal polyps.METHODS This prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. The primary outcome measures were en-bloc resection(endoscopic evaluation) and complete resection rates(pathological evaluation). The secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn't routinely performed.RESULTS Two hundred eight patients were randomized into the CSP(102), HFB(106) and 283 polyps were evaluated(CSP: 148, HFB: 135). The en-bloc resection rate was significantly higher with CSP than with HFB [99.3%(147/148) vs 80.0%(108/135), P < 0.0001]. The complete resection rate was significantly higher with CSP than with HFB [80.4%(119/148) vs 47.4%(64/135), P < 0.0001]. The immediate bleeding rate was similar between the groups [8.6%(13/148) vs 8.1%(11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. The rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6%(71/135) vs 1.3%(2/148), P < 0.0001]. Polyp retrieval failure was encountered CSP(7), HFB(2).CONCLUSION CSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required. | Yoriaki Komeda Hiroshi Kashida Toshiharu Sakurai George Tribonias Kazuki Okamoto Masashi Kono Mitsunari Yamada Teppei Adachi Hiromasa Mine Tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui Tomohiro Watanabe Masayuki Kitano Takaaki Chikugo Yasutaka Chiba Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，2： | 20 |
| 2 | Hepatocyte growth factor/Met system promotes endometrial and endometriotic stromal cell invasion via autocrine and paracrine pathway显示文摘 | Yoshida S Harada T Mitsunari M | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 3 | Role of cytokines in progression of endometriosis显示文摘 | Harada T Enatsu A Mitsunari M | 1999 | Gynecol Obster Inrest1999，47，： | 1 |
| 4 | Progesterone and progestational compounds attenuate tumor necrosis factor alpha-induced interleukin-8 production via nuclear factor kappa B inactivation in endometriotic stromal cells显示文摘 | Harada T Mitsunari M | 2005 | Fertil Steril2005，83，5： | 1 |
| 5 | Hepatocyte growth factor/Met system promotes endometrial and endometriotic stromal cell invasion via autocrine and paracrine pathways显示文摘 | Yoshido S Harada T Mitsunari M | 2004 | Clin Endocrinol Metab2004，89，2： | 1 |
| 6 | 显示文摘 | MITSUNARI I MIDORIKO O YASUYUKI A | 2005 | Inorg Chem2005，44，5： | 1 |
| 7 | Involvement of p38 MAP kinase in lipopolysaccharide - induced production of pro - and antiinflammatory cytokines and prostaglandin E(2 )in human choriodecidua 显示文摘 | Shoji T Yoshida S Mitsunari M | 2007 | J Repred Immuno12007，75，2： | 1 |
| 8 | Involvement of p38 MAP kinase in lipopolysaccharide-induced production of pro- and anti- inflammatory cytokines and prostaglandin E (2) in human choriodecidua 显示文摘 | Shoji T Yoshida S Mitsunari M | 2007 | J Reprod Immunol2007，75，2： | 1 |
| 9 | Involvement of p38 MAP kinase in lipopolysaccharide-induced production of pro- and anti-inflammatory cytokines and prostaglandin E (2) in hu- man choriodeeidua 显示文摘 | Shoji T Yoshida S Mitsunari M | 2007 | J Reprod Immunol2007，75，2： | 1 |
| 10 | Cervical Ureaplasma urealyticum colonization might be associated with increased incidence of preterm delivery in pregnant women without prophlogistic microorganisms on routine examination显示文摘 | Mitsunari M Yoshida S Deura I | 2005 | J Obstet Gynaecol Res2005，31，1： | 1 |
| 11 | Heme oxygenase-1 ex- pression is associated with tumor aggressiveness and outcomes in patients with bladder cancer: a correlation with smoking in- tensity显示文摘 | Miyata Y Kanda S Mitsunari K | 2014 | Transl Res2014，164，6： | 1 |
| 12 | A New Traitor Tracing显示文摘 | Mitsunari S Sakai R Kasahara M | 2002 | IEICE Transactions on Fundamentals of Electronics Communi- cations and Computer Sciences2002，85，2： | 1 |
| 13 | The potential role of stem cell factor and its receptor c-kit in the mouse blastocyst implantation显示文摘 | Mitsunari M Harada T Tanikawa M | 1999 | Mol Hum Reprod1999，5，9： | 1 |
| 14 | A new traitor tracing显示文摘 | S Mitsunari R Sakai M Kasahara | 2002 | IEICE Trans2002，85，2： | 1 |
| 15 | Cervical Ureaplasma Urealyticum colonization might be associated with increased incidence of preterm delivery in pregnant women withont prophlogistic microorganisms on routine examination显示文摘 | Yoshida S Deura I | 2005 | J Obstet Gynaecol Res2005，31，1： | 1 |
| 16 | The potential role of stem cell factor and its receptor c - kit in the mouse blastocyst implantation显示文摘 | Masahiro Mitsunari Tasuku Harada Masahiro Tanikawa | 1999 | Molecular Human Reproduction1999，5，9： | 1 |
| 17 | Cervical Ureaplasma urea- lyticum colonization might be associated with increased incidence of preterm delivery in pregnant women without prophlogistic micro- organisms on routine examination 显示文摘 | Mitsunari M Yoshida S Deura I | 2005 | 10bstet Gynaecol Res2005，31，1： | 1 |
| 18 | A new traitor tracing显示文摘 | MITSUNARI S SAKAI R KASAHARA M | 2002 | IEICE Tran2002，85，2： | 1 |
| 19 | Hepatocyte growth factor/Met system promotes endometrial and endometriotic stromal cell invasion via autocrine and paracrine pathways显示文摘 | Yoshida S Harada T Mitsunari M | 2004 | Clin Endocrinol Metab2004，89，2： | 1 |
| 20 | Hepatocyte growth factor/Met system promotes endometrial and endometriotic stromal cell invasion via autocrine and paracrine pathways显示文摘 | Yoshida S Harada T Mitsunari M | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
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