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| 1 | 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系显示文摘血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此类药物是治疗一些慢性病的必须药物,有建议停止使用这些药物. | Mehta N KalraA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) | 2020 | 中华高血压杂志2020，28，5： | 9 |
| 2 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 3 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 4 | Completeness of malaria notification in Tunisia assessed by capture recapture method显示文摘 | N Ben Alaya-Bouafif MK Chahed H El Bez H Bellali L Ayari N Achour | 2011 | Asian Pacific Journal of Tropical Disease2011，，3： | 2 |
| 5 | Germ cell deficient ( gcd ) mouse as a model of premature ovarian failure 显示文摘 | Duncan MK Cummings L Chada K | 1993 | Biol Reprod1993，49，2： | 1 |
| 6 | A clinical model to estimate the pretest probability of lung cancer in patients with solitary pulmonary nodules 显示文摘 | Gould MK Ananth L Barnett PG | 2007 | Chest2007，131，： | 1 |
| 7 | Diffusing capacity predicts morbidity and mortality after pulmonary resection显示文摘 | Ferguson MK Little L Rizzo L | 1988 | Thorac Cardiovasc Surg1988，96，6： | 1 |
| 8 | Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints显示文摘 | Parmar MK Torri V Stewart L | | 0，，24： | 1 |
| 9 | An attachment theory per- spective in the examination of relational processes associated with Coach-Athlete dyads 显示文摘 | Davis L Jowett S Lafreniere MK | 2013 | J Sport Exercise Psy2013，35，2： | 1 |
| 10 | Plant and microbial controls on nitrogen retention and loss in a humid tropical forest显示文摘 | Templer P H Silver W L Pett-Ridge DeAngelis J M K Firestone MK | 2008 | Ecology2008，89，11： | 1 |
| 11 | Mast cells and matrix degradation at sites of tumour invasion in rat mammary ade- nocarcinoma显示文摘 | Dabbous MK Walker R Haney L | 1986 | Br J Cancer1986，54，3： | 1 |
| 12 | Retinoic acid and interferon signaling cross talk in normal and RA-resistant APL cells 显示文摘 | Chelbi Alix MK Pelicano L | 1999 | Leukenia1999，13，8： | 1 |
| 13 | Extracting summary statistics to perform Meta-analysis of the published literature for survival endpoints显示文摘 | Parmar MK Torri V Stewart L | 1998 | Stat Med1998，17，9： | 1 |
| 14 | Effect of Sttin therpy on risk of ventriculr rrhythmi among ptients with coronry rtery disese and implntble crdioverter-defibrilltor显示文摘 | Chiu JH bdelhdi RH Chung MK et l | 2005 | m J Crdiol2005，95，： | 1 |
| 15 | Host mediated effectors of tumor invasion: role of mast cells in matrix degradation显示文摘 | Dabbous MK Woolley DE Haney L | 1986 | Clin Exp Metastasis1986，4，2： | 1 |
| 16 | Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3显示文摘 | Jungnickel MK Marrero H Birnbaumer L | | 0，，05： | 1 |
| 17 | Increased age,high body mass index and low HDL-C levels are related to an echolucent carotid intimamedia:the METEOR study显示文摘 | Peters SA Lind L Palmer MK | | 0，，03： | 1 |
| 18 | Long-term outcone of percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy:a scandinavian muhicenter study 显示文摘 | Jensen MK Almass VM Jacobsson L | 2011 | Circ Cardiovasc in- terv2011，4，3： | 1 |
| 19 | Speckle tracking echocar- diography in pediatric and congenital heart disease 显示文摘 | Forsey J Friedberg MK Mertens L | 2013 | Echocar- diography2013，30，4： | 1 |
| 20 | Host mediated effectors of tumor invasion: role of mast cells in matrix degradation显示文摘 | Dabbous MK Woolley DE Haney L | 1986 | Clin Exp Metastasis1986，4，2： | 1 |
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