|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 2 | 糖尿病性上消化道感觉和运动功能异常显示文摘糖尿病患者胃肠感觉运动功能异常非常常见,其可涉及胃肠道各个部位。糖尿病性胃肠异常经常是亚临床的,庆幸的是罕有严重和危及生命的问题发生。人们尚未完全了解糖尿病性上消化道感觉运动功能异常的发病机制,但是其机制似乎是多源性的。研究表明,糖尿病性自主神经病变和急性血糖异常可损伤感觉运动功能。糖尿病发展过程中胃肠道结构和生物力学特性的重构也可能与感觉运动功能异常有关。本综述只讨论糖尿病性上消化道感觉运动功能异常,同时结合讨论胃肠道结构和生物力学特性的重构在糖尿病性上消化道感觉运动功能异常发展中的作用。 | 赵静波 Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Niels Ejskjaer | 2008 | 医学综述2008，14，23： | 6 |
| 3 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 4 | Imaging of the gastrointestinal tract-novel technologies显示文摘Imaging of the gastrointestinal tract is very useful for research and clinical studies of patients with symptoms arising from the gastrointestinal tract and in visualising anatomy and pathology. Traditional radiological techniques played a leading role in such studies for a long time. However, advances in non-invasive modalities including ultrasound (US), computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), etc, have in the last decades revolutionised the way in which the gastrointestinal tract is studied. The resolution of imaging data is constantly being improved and 3D acquisition, tools for fi ltering, enhancement, segmentation and tissue classif ication are continually being developed. Additional co-registration techniques allow multimodal data acquisition with improved classif ication of tissue pathology. Furthermore, new functional imaging techniques have become available. Altogether, the future of gastrointestinal imaging looks very promising which will be of great benef it in clinical and research studies of gastrointestinal diseases. The purpose of this review is to highlight the capabilities of the newest techniques to explore the detailed morphology, biomechanical properties, function and pathology of the gastrointestinal tract. | Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 5 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 6 | Influence of bilateral skeletonized harvesting on occurrence of deep sternal wound infection in 1 000 consecutive patients undergoing bilateral internal thoracic artery grafting显示文摘 | Mohr R Lev-Run O | 2003 | Ann Surg2003，237，2： | 1 |
| 7 | Distributed performance monitoring: methods, tools, and applications 显示文摘 | Hofmann R Klar P Mohr B | 1994 | IEEE Transactions on Parallel and Distributed Systems1994，5，6： | 1 |
| 8 | Early clinical differentiation of cerebral infarction from severe atherosclerotic stenosis and cardioembolism 显示文摘 | TIMSIT S G SACCO R L MOHR J P | 1992 | Stroke1992，23，4： | 1 |
| 9 | The sensitivity of West African convective line water budgets to land cover显示文摘 | MOHR K I BAKER R D TAO W K | 2003 | J Hydrometeor2003，4，1： | 1 |
| 10 | Characteristics of partnership success: partnership attributes, communication behaviour and conflict resolution techniques显示文摘 | MOHR J SPEKMAN R | 1994 | Strategic Management Journal1994，15，2： | 1 |
| 11 | Collaborative communication in interfirm relationships:moderating effects of integration and control显示文摘 | MOHR J J FISHER R J NEVIN J R | 1996 | Journal of Marketing1996，60，3： | 1 |
| 12 | On Single Scan Line Camera Calibration 显示文摘 | HORAUD R MOHR R LORECKI B | 1993 | IEEE Transactions on Robotics and Automation1993，9，1： | 1 |
| 13 | Collaborative Communication in Interfmn Relationships: Moderating Effects of Integration and Control显示文摘 | Mohr J J Fisher R J Nevin J R | 1996 | Journal of Marketing1996，60，7： | 1 |
| 14 | Semantic'conduction aphasia from a posterior insular cortex infarction显示文摘 | Marshall R Lazar R Mohr J | 1996 | J Neuroimaging1996，6，： | 1 |
| 15 | Evaluation of Interesting Point Detectors显示文摘 | Schmid C Mohr R Banckhage C | 2000 | International Journal of Computer Vision2000，37，2： | 1 |
| 16 | Percutaneous left atrial appendage transeatheter occlusion (PLAATO):planning lollowup using contrast-enhanced MRI显示文摘 | Mohrs O Schraeder R Petersen S | | 0，，2： | 1 |
| 17 | Characteristics of partnership suc- cess: Partnership tributes, communication behavior and conflict resolution techniques 显示文摘 | Mohr J Spekman R | 1994 | Strategic Manage- ment Journal1994，，15： | 1 |
| 18 | Evaluation of interesting point detectors显示文摘 | SCHMID C MOHR R BAUCKHAGE C | 2000 | International Journal of Computer Vision2000，37，2： | 1 |
| 19 | Enzyme biosensor for urea based on a novel pH bulk optode membrane显示文摘 | KONCKI R MOHR G J WOLFBEIS O S | 1995 | Biosens Bioelectron1995，10，8： | 1 |
| 20 | Surgical management of giant pituitary adenomas显示文摘 | Mohr G Hardy J Comtois R | 1990 | Can J Neurol Sci1990，17，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员