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| 1 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 2 | Active control of flow separation over an airfoil using synthetic jets显示文摘 | You D Moin P | 2008 | J Fluid Struct2008，24，8： | 1 |
| 3 | Active control of flow separation over an airfoil using synthetic jets 显示文摘 | You D Moin P | 2008 | Journal of Fluids and Structures2008，24，8： | 1 |
| 4 | Progress-variable approach for large-eddy simulation of non-premixed turbulent combustion显示文摘 | Pierce C D Moin P | 2004 | Journal of Fluid Mechanics2004，504，： | 1 |
| 5 | A dynamic global-coefficient subgrid- scale eddyviscosity model for large-eddy simulation in complex geometries 显示文摘 | You D Moin P | 2007 | Physics of Fluids2007，19，06： | 1 |
| 6 | Active control of flow separation over an airfoil using synthetic jets显示文摘 | You D Moin P | 2008 | Journal of Fluids and Structures2008，24，8： | 1 |
| 7 | A dynamic global-coefficient subgrid- scale model for large-eddy simulation of turbulent scalar transport in complex geometries显示文摘 | You D Moin P | 2009 | Physics of Fluids2009，21，04： | 1 |
| 8 | NF-кB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome显示文摘 | MOINE P MclNTYRE R SCHWARTZ M D | 2000 | Shock2000，13，2： | 1 |
| 9 | Effects of tip-gap size on the tip-leakage flow in a turbomachinery cascade显示文摘 | You D Wang M Moin P | 2006 | Phys Fluids2006，18，10： | 1 |
| 10 | Turbulence statistics in fully developed channel flow at low Reynolds number显示文摘 | KIM J MOIN P MOSER R D | 1987 | J Fluid Mecb1987，177，： | 1 |
| 11 | Amylase on Pecten maximus (Mollusca, bivalves): protein and cDNA characterization; quantification of the expression in the digestive gland 显示文摘 | Le Moine S Sellos D Moal J | 1997 | Mol Mar Biol Biotechnol1997，6，3： | 1 |
| 12 | Active control of flow separation over an airfoil using synthetic jets 显示文摘 | YOU D MOIN P | 2008 | Journal of Flu- ids and Structures2008，24，8： | 1 |
| 13 | PLGAPEG microspheres of teverelixj influence of polymer type on mierosphere characteristics and on teverelix in vitro release显示文摘 | MALLARDE D BOUTIGNON F MOINE F | 2003 | lnt J Pharm2003，261，12： | 1 |
| 14 | Progress-Variable Approach for Large-Eddy Simulation of Non-Premixed Turbulent Combustion 显示文摘 | Pierce C D Moin P | 2004 | Journal of Fluid Mechanics2004，504，： | 1 |
| 15 | Progress-variable approach for large-eddy simulation of non-premixed turbulent combustion显示文摘 | Pierce C D Moin P | 2004 | Journal of Fluid Mechanics2004，504，： | 1 |
| 16 | The effects of curvature in wall-bounded turbulent flow显示文摘 | MOSER R D MOIN P | 1987 | Journal of Fluid Mechanics1987，175，： | 1 |
| 17 | Effects of hydrophobic surfaces on the drag and lift of a circular cylinder显示文摘 | You D Moin P | 2007 | Physics of Fluids2007，19，8： | 1 |
| 18 | On the representation of backscatter in dynamic localization models 显示文摘 | Carati D Ghosal S Moin P | 1995 | Physics ofFluids1995，7，3： | 1 |
| 19 | Progress-va riable approach for largeeddy simulation of non-premixed turbulent combustion显示文摘 | Pierce C D Moin P | 2004 | Journal of Fluid Mechanics2004，127，： | 1 |
| 20 | On the representation of backscatter in dynamic localization models 显示文摘 | Carati D Ghosal S Moin P | 1995 | Physics of Fluids1995，7，3： | 1 |
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