|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B_(12) status显示文摘AIM:To evaluate joint effects of Methylentetra-hydrofolate reductase(MTHFR) C677T genotypes,and serum folate/vitamin B12 concentrations on promoter methylation of tumor-associated genes among Iranian colorectal cancer patients. METHODS:We examined the associations between MTHFR C677T genotype,and promoter methylation of P16,hMLH1,and hMSH2 tumor-related genes among151 sporadic colorectal cancer patients. The promoter methylation of tumor-related genes was determined by methylation-specific PCR. Eighty six patients from whom fresh tumor samples were obtained and 81 controls were also examined for serum folate and vitamin B12 concentrations by a commercial radioimmunoassay kit. RESULTS:We found 29.1% of cases had tumors with at least one methylated gene promoter. In case-case comparison,we did not find a significant association between methylation in tumors and any single genotype. However,in comparison to controls with the CC genotype,an increased risk of tumor methylation was associated with the CT genotype(OR = 2.5;95% CI,1.1-5.6) . In case-case comparisons,folate/vitamin B12 levels were positively associated with tumor methylation. Adjusted odds ratios for tumor methylation in cases with high(above median) versus low(below median) serum folate/vitamin B12 levels were 4.9(95% CI,1.4-17.7) ,and 3.9(95% CI,1.1-13.9) ,respectively. The frequency of methylated tumors was significantly higher in high methyl donor than low methyl donor group,especially in those with MTHFR CT(P = 0.01) ,and CT/TT(P = 0.002) genotypes,but not in those with the CC genotype(P = 1.0) . CONCLUSION:We conclude that high concentrations of serum folate/vitamin B12 levels are associated with the risk of promoter methylation in tumor-specific genes,and this relationship is modified by MTHFR C677T genotypes. | Pooneh Mokarram Fakhraddin Naghibalhossaini Mehdi Saberi Firoozi Seyed Vahid Hosseini Ahmad Izadpanah Heshmetalah Salahi Seyed Ali Malek-Hosseini Abdoulrasool Talei Mehra Mojallal | 2008 | World Journal of Gastroenterology2008，14，23： | 5 |
| 2 | The extended transverse musculocutaneous gracilis flap vascular anatomy and clinical implications显示文摘 | Wong C Mojallal A Bailey SH | 2011 | Ann Plast Surg2011，67，2： | 1 |
| 3 | Optimization of a culture medium for the differentiation of preadipocytes into adipocytes in a monolayer显示文摘 | Lequeux C Auxenfans C Mojallal A | 2009 | Biomed Mater Eng2009，19，45： | 1 |
| 4 | The five-step lower blephar-oplasty , blending the eyelid-cheekJunction显示文摘 | Rohrich RJ Ghavami A Mojallal A | 2011 | Plast Reconstr Surg2011，128，3： | 1 |
| 5 | Improvement of skin qualityafter fat grafting:clinical observation and an animal study显示文摘 | Mojallal A Lequeux C Shipkov C | 2009 | PlastReconstr Surg2009，124，： | 1 |
| 6 | 五步法下睑成形术:睑-颊结合处的处理显示文摘背景与目的对于下睑成形术而言,如果操作不当或忽视了眼轮匝肌的解剖作用,可能造成显著的远期并发症及达不到美学效果。如此可极大降低手术效果,无法实现出色的眶周年轻化手术治疗。因此,本文充分依据解剖学原则,提出一项简单易行的“五步法”下睑成形术。方法对50例应用五步法行双侧下睑成形术患者的疗效进行回顾性分析,以改进下睑美容手术。应用计算机程序,通过对标准化的数据点测量得到的比例,对50例首次行下睑成形术的患者(100侧下睑;37例女性,13例男性)的数码照片进行测量分析。结果通过对100侧经五步法下睑成形术的100侧下睑分析,发现其并发症发生率低,且数据点测量证实所有美学参数都得到了改善。泪槽宽度及位置、下睑相对于瞳孔的位置、内眦形态都得到了改善。无一例出现下睑位置不佳。结论建立在解剖学基础上的五步法技术可以有效提高下睑成形术的美学效果。下睑成形术的疗效可通过以下途径得到改善:①填充有支撑作用的深层颧脂肪室;②如果需要去除少量脂肪,应当保留下睑眼轮匝肌;③主要支持结构(眼轮匝肌支持韧带)可以选择性地松解;④建立或加强外眦支撑(外眦韧带悬吊);⑤切除少量皮肤。(循证医学临床证据等级:疗法类,Ⅳ级) | RodJ.Rohrich Ashkan Ghavami Ali Mojallal | 2012 | 中国美容整形外科杂志2012，23，9： | 1 |
| 7 | Improvement of skin quality after fat grafting: clinical observation and an ani- mal study 显示文摘 | Mojallal A Lequeux C Shipkov C | 2009 | Plast Reconstr Surg2009，124，3： | 1 |
| 8 | Improvement of skin quality after fat grafting:clinical observation and an animal study 显示文摘 | Mojallal A Lequeux C Shipkov C | 2009 | Plast Reconstr Surg2009，124，3： | 1 |
| 9 | 可用于临床的脂肪组织基础知识概述显示文摘脂肪组织中含有干细胞,这一认识促使我们进一步探索在更广泛的临床状况下利用脂肪和脂肪来源干细胞的可能性。关于脂肪来源干细胞的获取、分离以及分离的脂肪来源干细胞的分化特性的新知识已带来新的研究,这些新研究的研究方向是新的组织工程构建,以及脂肪来源干细胞转化为诱发的多能干细胞。临床上,脂肪移植物和脂肪来源干细胞在美国及全世界范围内的使用急剧增加,同时,以脂肪来源干细胞为基础的治疗方法的安全性和有效性带来的问题也随之增多。当前,FDA还未批准分离的脂肪来源干细胞用于任何临床领域。 | Spencer A. Brown Benjamin Levi Charlotte Lequex Victor W. Wong All Mojallal Michael T. Longaker 魏峰(译) 高景恒(译) 张晨(译) | 2011 | 中国美容整形外科杂志2011，22，7： | 1 |
| 10 | Improvement of skin quality after fat grafting:clinieal observation and an animal study显示文摘 | MOJALLAL A LEQUEUX C SHIPKOV C | 2009 | Hast Reconstr Surg2009，124，3： | 1 |
| 11 | The five-step lower blephar- oplasty: Blending the eyelid-cheek junction 显示文摘 | Rohrich R J Ghavami A Mojallal A | 2011 | Plast Reconstr Surg2011，128，3： | 1 |
| 12 | Stem cells mature adipocytes, and extraeellular scaffold:what dose each contribute to fat graft surviv- al显示文摘 | Mojallal A Lequeux C Shipkov C | 2011 | Aesthetic Plast Surg2011，35，6： | 1 |
| 13 | Foot defect with vascular and neural injury due to freshwater stingray sting:reconstruction with a lesser saphenous vein adipo-fascial flap显示文摘 | Moutran M Mojallal A Chekaroua K | | 0，，02： | 1 |
| 14 | Stem cells,mature adipocytes,and extracellular scaffold:what does each contribute to fat graft survival显示文摘 | Mojallal A Lequeux C Shipkov C | | 0，，06： | 1 |
| 15 | Perforasomes of the DIEP flap : vascular anatomy of the lateral versus medial row perforators and clinical implications显示文摘 | Wong C Saint-Cyr M Mojallal A | 2010 | Plast Reconstr Surg2010，125，3： | 1 |
| 16 | Dorsal aesthetic lines in rhinoplasty: a quantitative outcome-based assessment of the component dorsal reduction technique 显示文摘 | Mojallal A Ouyang D Saint-Cyr M | 2011 | Plast Reconstr Surg2011，128，1： | 1 |
| 17 | Influence of age and body mass index on the yield and proliferation capacity of adipose-derived stem cells显示文摘 | Mojallal A Lequeux C Shipkov C | 2011 | Aesthet Plast Surg2011，35，6： | 1 |
| 18 | Influence of the recipient site on the outcomes of fat grafting in facial reconstructive surgery 显示文摘 | MOJALLAL A SHIPKOV C BRAYE F | 2009 | Plast Reconstr Surg2009，124，2： | 1 |
| 19 | Influence of the recipient site on the outcomes of fat grafting in facial reconstruc- tive surgery显示文摘 | MOJALLAL A SHIPKOV C BRAYE F | 2009 | Plast Reconstr Surg2009，124，2： | 1 |
| 20 | Psychosocial complications of coronary artery disease 显示文摘 | KARIMIMOONAGHI H MOJALLI M KHOSRAVAN S | 2014 | Iran Red Crescent Med J2014，16，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员