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| 1 | Potential predictive factors for pathologic complete response after the neoadjuvant treatment of rectal adenocarcinoma:a single center experience显示文摘Objective:To assess the response rate of patients with rectal adenocarcinoma to neoadjuvant therapy and to identify the predictors of histological regression after neoadjuvant radiotherapy(RT)or concurrent chemoradiotherapy(CCRT).Methods:This study recruited 64 patients.The patients had resectable cancer of the lower and the middle rectum(T3/T4 and/or N+)without distant metastasis and received neoadjuvant RT or CCRT followed by radical surgery with total mesorectal excision(TME)between January 2006 and December 2011.The patients were classified into non-response(NR),partial response(PR),and pathologic complete response(p CR)based on the Dworak tumor regression grading system.Results:The median age of patients was 57 years(ranging from 22 to 85).A total of 24 patients were treated with neoadjuvant CCRT,whereas 40 patients were treated with RT alone.Abdominoperineal resection(APR)was performed on 29 patients(45%).Anterior resection with TME was performed on 34 patients(53%).One patient had local resection.Histologically,12(19%),24(73%),and 28(44%)patients exhibited p CR,PR,and NR,respectively.Univariate analysis revealed that the predictors of tumor regression were as follows:the absence of lymph node involvement from initial imaging(c N0)(P=0.021);normal initial carcinoembryonic antigen(CEA)level(P=0.01);hemoglobin level≥12 g/dl(P=0.009);CCRT(P=0.021);and tumor downstaging in imaging(P=0.001).Multivariate analysis showed that the main predictors of p CR were CT combined with neoadjuvant RT,c N0stage,and tumor regression on imaging.Conclusions:Identifying the predictors of p CR following neoadjuvant therapy aids the selection of responsive patients for nonaggressive surgical treatment and possible surveillance. | Feryel Letaief Meher Nasri Mouna Ayadi Khedija Meddeb Amina Mokrani Yosra Yahyaoui Nesrine Chraiet Henda Raies Amel Mezlini | 2017 | Cancer Biology & Medicine2017，14，3： | 3 |
| 2 | Gas conversion to liquid fuels and chemicals: the methanol route- catalysis and processes development显示文摘 | Mokrani T Scurrell M | 2009 | Catalysis Reviews2009，51，： | 1 |
| 3 | The effects of chaotic advection on heat transfer显示文摘 | MOKRANI A CASTELAIN C PEERHOSSAINI H | 1997 | International Journal of Heat and Mass Transfer1997，40，13： | 1 |
| 4 | Experimentalstudy of the influence of the rows of vortex generators onturbulence structure in a tube显示文摘 | Mokrani A Castelain C Peerhossaini H | 2007 | Nuclear Engineering andDesign2007，237，7： | 1 |
| 5 | Fluid flow and convective heat transfer in flat microchannels显示文摘 | Omar Mokrani Brahim Bourouga Cathy Castelain | 2009 | International Journal of Heat and Mass Transfer2009，52，： | 1 |
| 6 | Gas conversion to liquid fuels and chemicals: the methanol route- catalysis and processes development显示文摘 | T Mokrani M Scurrell | 2009 | Catalysis Reviews2009，51，： | 1 |
| 7 | A fuzzy global efficiency optimization of a photovohaic water pumping system 显示文摘 | BENLARBI K MOKRANI L NAIT-SAID M S | 2004 | Solar Energy2004，77，2： | 1 |
| 8 | MRI Images Segmentation by FCM and Neighbor's Statistical Characteristics 显示文摘 | Nadjib Nasri Karim Mokrani Abdenour Mekhmoukh | 2012 | International Journal of Research and Reviews in Soft and Intelligent Computing2012，2，1： | 1 |
| 9 | Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hem- atopoietic progenitors 显示文摘 | Pronier E Almire C Mokrani H | 2011 | Blood2011，118，9： | 1 |
| 10 | Thyroid axis activity and sui- cidal behavior in depressed patients 显示文摘 | Duval F Mokrani MC Lopera FG | 2010 | Psychoneuroendocrinology2010，35，7： | 1 |
| 11 | Experimental study of the influence of the rows of vortex generators on turbulence structure in a tube显示文摘 | Mokrani A Castelain C Peerhossaini H | 2009 | Chemical Engineering and Processing2009，48，2： | 1 |
| 12 | Experimental study of the influence of the rows of vortex generators on turbulence structure in a tube显示文摘 | Mokrani A Castelain C Peerhossaini H | 2009 | Chemical Engineering and Processing2009，48，2： | 1 |
| 13 | The Effect of Chaotic advection on Heat Transfer显示文摘 | MOKRANI A | 1997 | International Journal of Heat and Mass Transfer1997，40，13： | 1 |
| 14 | Anal and anal margin tumors显示文摘 | Chatelain D Mokrani N Flejou J F | 2007 | AnnPathol2007，27，6： | 1 |
| 15 | The challenge of new competition on the world market for Tunisian olive oil exports: a Shift-Share analysis显示文摘 | Mokrani Aicha Sai Mohamed Bechir and Dhehibi Boobaker | 2011 | NEW MEDIT2011，10，4： | 1 |
| 16 | Cortisol hypersecretion in unipolar major depression with melancholic and psychotic features:dopaminergic,noradrenergic and thyroid correlates显示文摘 | Duval F Mokrani MC Monreal-Ortiz JA | 2006 | Psychoneuroendocrinology2006，31，7： | 1 |
| 17 | Relationship between prolactin secretion, and plasma risperidone and 9-hydrox- yrisperidone concentrations in adolescents with schizophreniform disorder显示文摘 | Duval F Guillon MS Mokrani MC | 2008 | Psychnneuroendocrinology2008，33，2： | 1 |
| 18 | Cortisol hypersecretion in unipolar major depression with melancholic and psychotic features: dopaminergic, noradrenergic and thyroid correlates 显示文摘 | Duval F Mokrani M C Monrea-Ortiz J A | 2006 | Psychoneuroendocrinology2006，31，7： | 1 |
| 19 | Electrochemical and photo-electrochemical properties of carbon spheres prepared via chemical vapor deposition 显示文摘 | Boudjemaa A Mokrani T Bachari K | 2015 | Mater Sei Semiconductor Processing2015，30，： | 1 |
| 20 | Modeling,control and power management of hybrid photovoltaic fuel cells with battery bank supplying electric vehicle显示文摘 | Mokrani Z Reki oua D Reki oua T | 2011 | International Journal of Hydrogen Energy2011，39，15： | 1 |
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