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| 1 | Bile acids:Chemistry,physiology,and pathophysiology显示文摘The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physical-chemical and biological characteristics.They are synthesized by the liver from cholesterol through several complementary pathways that are controlled by mechanisms involving finetuning by the levels of certain bile acid species.Although their best-known role is their participation in the digestion and absorption of fat,they also play an important role in several other physiological processes.Thus,genetic abnormalities accounting for alterations in their synthesis,biotransformation and/or transport may result in severe alterations,even leading to lethal situations for which the sole therapeutic option may be liver transplantation.Moreover,the increased levels of bile acids reached during cholestatic liver diseases are known to induce oxidative stress and apoptosis,resulting in damage to the liver parenchyma and,eventually,extrahepatic tissues.When this occurs during pregnancy,the outcome of gestation may be challenged.In contrast,the physical-chemical and biological properties of these compounds have been used as the bases for the development of drugs and as pharmaceutical tools for the delivery of active agents. | Maria J Monte Jose JG Marin Alvaro Antelo Jose Vazquez-Tato | 2009 | World Journal of Gastroenterology2009，15，7： | 36 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 4 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 5 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 6 | Respiratory muscle and cardiopulmonary function during exercise in very severe COPD显示文摘 | Montes de Oca M Rassulo J Celli BR | 1996 | Am J Respir Crit Care Med1996，154，： | 1 |
| 7 | Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair 显示文摘 | Kuhn B del Monte F Hajjar R J | 2007 | Nat Med2007，13，8： | 1 |
| 8 | On the role of oxygen storage in three-way catalysis显示文摘 | MONTE R D KASPAR J | 2004 | Topics in Catalysis2004，28，14： | 1 |
| 9 | Seasonal patterns ofcarbon dioxide,water vapour and energy fluxes in pin-eapple显示文摘 | JoséJ S Montes R Nikonova N | 2007 | Agricultural and Forest Meteorology2007，147，12： | 1 |
| 10 | Seasonal patterns of carbon dioxide, water vapour and energy fluxes in pineapple显示文摘 | Jos6 J S Montes R Nikonova N | 2007 | Agricultural and Forest Meteorology2007，147，12： | 1 |
| 11 | Influence of particle size on extrapleural talc dissemination after talc slurry pleurodesis显示文摘 | Ferrer J Montes JF Villarino MA | 2002 | Chest2002，122，3： | 1 |
| 12 | Influence of personal mastery on organization- al performance through organizational learning and inno- vation in large firms and SMEs 显示文摘 | Garcia - Morales V J Llor6ns - Montes F J Verd6 - Jover A J | 2007 | Technovation2007，27，： | 1 |
| 13 | A new approach to the differential diagnosis of a regular tachycardia with a wide QRS complex显示文摘 | Brugada P Brugada J Mont L | 1991 | Circulation1991，83，3： | 1 |
| 14 | Enthalpies of combustion, vapour pressures, and enthalpies of sublimation of 8- hydroxyquinoline, 5-nitro-8-hydroxyquinoline, and 2-methyl-8-hydroxyquinoline显示文摘 | Ribeiro Da Silva M A V Monte M J S Matos M A R | 1989 | Chem Thermodyn1989，，21： | 1 |
| 15 | Acute generalized, widespread bleeding, diagnosis and management显示文摘 | ROCHA E PARAMO J A MONTES R | 1998 | Haematologica1998，83，： | 1 |
| 16 | Nitric oxide and ethylene emission in Arabidopsis thaliana 显示文摘 | Magalhaes J R Monte D C Durzan D | 2000 | Physiol Mol Biol Plant2000，6，： | 1 |
| 17 | Dependence of release variables in the shot put显示文摘 | Mont Hubbard Neville J de Mestre John Scott | 2000 | Journal of Biomechanics2000，，134： | 1 |
| 18 | Osteonecrosis of thehip : management in the 21st century 显示文摘 | Lieberman J R Berry D J Mont M A | 2003 | Instr Course Lect2003，52，： | 1 |
| 19 | CPI-extensions:overrings of integral domains with special prime spectrums显示文摘 | Monte B Boisen J R Sheldon P H | 1997 | Can J Math1997，4，： | 1 |
| 20 | Usefulness of high - sensitivity c - reactive protein to predict mortality in patients with atrial fibrillation (from the Atherosclerosis Risk in Communities study) 显示文摘 | HERMIDA J LOPEZ F L MONTES R | 2012 | Am J Cardiol2012，109，1： | 1 |
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