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| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | High prevalence of antifungal resistance in Candida spp from patients with AIDS 显示文摘 | Law D Moore C B Wardle H M | 1994 | J Antimicrob Chemother1994，34，5： | 2 |
| 5 | The influence of uncertainty in illness, stress appraisal, and hope on coping in survivors of breast cancer显示文摘 | WONGHONGKUL T MOORE M MUSIL C | 2000 | Cancer Nurs2000，23，6： | 1 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | ARMAX modal parameter identification in the presence of unmeasured excitation-Ⅰ:theoretical background显示文摘 | Moore S M Lai J C S | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 8 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 9 | The Lessons We (don't) Learn : Counterfactual Thinking and Organizational Accountability After a Close Call 显示文摘 | Morris M W Moore P C | 2000 | Administrative Science Quarterly2000，45，12： | 1 |
| 10 | Fiekian diffusion of radionuclides for engineered contain- ment harriers: Diffusion coefficients, porosities, and complicating issues显示文摘 | SHACKELFORD C D MOORE S M | 2013 | Engineering Geolo- gy2013，152，： | 1 |
| 11 | Murine models of puhnonary fi- brosis显示文摘 | Moore B B Hogaboam C M | 2008 | Am J Physiol Lung Cell Mol Physiol2008，294，2： | 1 |
| 12 | A novel tryptase inhibitor, APC 366, inhibits allergeninduced airway and inflammatory responses in allergic sheep 显示文摘 | Clark J M Moore W R Fishman C E | 1995 | Am J Respir Crit Care Med1995，152，6： | 1 |
| 13 | Influence of the glycerol concentration on some physical properties of feather keratin films显示文摘 | MOORE G R MARTELLI S M GANDOLFO C | 2006 | FoodHydrocolloids2006，20，7： | 1 |
| 14 | Finding Community Structure in Very Large Networks显示文摘 | Clauset A Newman M E J Moore C | 2004 | Physical Review E2004，，06： | 1 |
| 15 | Time-dependence of hazard ratios for prognostic factors in primary breast cancer显示文摘 | HILSENBECK S G RAVDIN P M DE MOOR C A | 1998 | Breast Cancer Res Treat1998，52，13： | 1 |
| 16 | ARMAX modal parameter identification in the presence of unmeasured excitation-Ⅱ:numerical and experimental verification显示文摘 | Moore S M Lai J C S | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 17 | De-mand articulation in emerging technologies: intermediary user organisations as co-producers? 显示文摘 | BOON W P C MOORS E H M KUHLMANN S | 2010 | Research Policy2010，40，2： | 1 |
| 18 | Characterization of conservedhuman immunodeficiency virus type I gp120 neutralization epitopes ex-posed upon gp120-CD4 biding显示文摘 | Moore JP Furman C | 1993 | J Virol1993，67，： | 1 |
| 19 | Splicing of precursors to mRNA by the spliceosome显示文摘 | QUERYC C SHARPPA | 1999 | RNA World1999，，： | 1 |
| 20 | Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocareinoma of the uterus 显示文摘 | Moore R G Brown A K Miller M C | 2008 | Gyneeol Oneol2008，110，2： | 1 |
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