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| 1 | 运用PTEN和ERG免疫染色区分针吸活检组织中前列腺导管内癌以及高级别PIN显示文摘前列腺导管内癌和高级别上皮内瘤变(PIN)在治疗方案上有着显著的区别,但二者的针吸活检组织很难区分。在前列腺根治标本中,作者发现运用PTEN和ERG的免疫组化染色可以解决这一难题。作者在实验中进一步验证在针吸标本中这些标志物是否有用。单独或组合的免疫标记法运用于形态学明确的导管内癌、PIN、交界性导管内增生的活检,后者缺乏类似于导管内癌的形态学准则而比PIN更令人担忧。 | Morais C L Han J S Gordetsky J 徐磊 孙咏梅 | 2015 | 临床与实验病理学杂志2015，31，4： | 11 |
| 2 | Methane production and small intestinal bacterial overgrowth in children living in a slum显示文摘AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests.METHODS:This transversal study included 85 children residing in a slum and 43 children from a private school,all aged between 6 and 10 years,in Osasco,Brazil.For characterization of the groups,data regarding the socioeconomic status and basic housing sanitary conditions were collected.Anthropometric data was obtained in children from both groups.All children completed the hydrogen(H 2) and methane(CH 4) breath test in order to assess small intestinal bacterial overgrowth(SIBO).SIBO was diagnosed when there was an increase in H 2 ≥ 20 ppm or CH 4 ≥ 10 ppm with regard to the fasting value until 60 min after lactulose ingestion.RESULTS:Children from the slum group had worse living conditions and lower nutritional indices than children from the private school.SIBO was found in 30.9%(26/84) of the children from the slum group and in 2.4%(1/41) from the private school group(P = 0.0007).Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school(P = 0.007).A higher concentration of hydrogen in the small intestine(P < 0.001) and in the colon(P < 0.001) was observed among the children from the slum group with SIBO when compared to children from the slum group without SIBO.Methane production was observed in 63.1%(53/84) of the children from the slum group and in 19.5%(8/41) of the children from the private school group(P < 0.0001).Methane production was observed in 38/58(65.5%) of the children without SIBO and in 15/26(57.7%) of the children with SIBO from the slum.Colonic production of hydrogen was lower in methaneproducing children(P = 0.017).CONCLUSION:Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane production.Hydrogen is a substrate for methane production in the colon. | Carolina Santos Mello Soraia Tahan Lígia Cristina FL Melli Mirian Silva do Carmo Rodrigues Ricardo Martin Pereira de Mello Isabel Cristina Affonso Scaletsky Mauro Batista de Morais | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 3 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 4 | Examining the role of cognitive and affective image in predicting choice across natural, developed, and theme-park destinations 显示文摘 | Lin C H Morais D B Kerstetter D L | 2007 | Journal of Travel Research2007，46，2： | 1 |
| 5 | Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae显示文摘 | VURALHAN Z MORAIS M A TAI S L | 2003 | Applied and Environmental Microbiology2003，69，8： | 1 |
| 6 | Analysis of solid wood beams strengthened with CFRP laminates of distinct lengths显示文摘 | DE JESUS A M P PINTO J M T MORAIS J J L | 2012 | Construction and Building Materials2012，35，1： | 1 |
| 7 | Primary spinal glioblastoma: A case report and review of the literature 显示文摘 | Morais N Mascarenhas L Soares- Femandes JP | 2013 | Oncol Lett2013，5，： | 1 |
| 8 | Use of advanced oxidation processes to improve the biodegradability of mature landfill leachates显示文摘 | Morais J L D Zamora P P | 2005 | Journal of Hazardous Materials2005，123，123： | 1 |
| 9 | Interactions between the NO-citrulline cycle and brain-derived neurotrophic factor in differentiation of neural stem cells显示文摘 | Lameu C Trujillo C A Schwindt T T Negraes P D Pillat M M Morais K L | | 0，，： | 1 |
| 10 | Combined effects of chemical dip and/or carrageenan coating and/or controlled atmo- sphere on quality of fresh-cut banana显示文摘 | BICO S L S RAPOSO M F J MORAIS R M S C | 2009 | Food Control2009，20，5： | 1 |
| 11 | Nitriding of titanium disks and industrial dental implants using hollow cathode discharge显示文摘 | Jr ALVES C GUERRA NETO C L B MORAIS G H S | 2006 | Surface and Coatings Technology2006，200，： | 1 |
| 12 | Studies on the density,heat capacity,surface tension and infinite dilution diffu-sion with the ionic liquids , , and 显示文摘 | de CASTRO C A N LANGA E MORAIS A L | 2010 | Fluid Phase Equilibria2010，294，12： | 1 |
| 13 | Conventional and high-dose daunorubiein and idarubicin in acute myeloid leukaemia remission induction treatment: a mixed treatment comparison meta-analysis of 7258 patients 显示文摘 | SEKINE L MORAIS V D LIMA K M | 2014 | Hematol On- col2014，，： | 1 |
| 14 | Gene expression of the POU factor Brn3a is regulated by two different promoters显示文摘 | Vassen L Moray T | 2002 | Biochim Biophys Acta2002，1579，23： | 1 |
| 15 | Patient satisfaction following day surgery显示文摘 | Paulo L Ana P Morais G | 2009 | J Clin Anesth2009，21，3： | 1 |
| 16 | Optic nerve enlargement and leukodystrophy: an unusual finding of the infantile form of Krabbe disease显示文摘 | Garcia AM Morais NM Ohlweiler L | 2010 | Arq Neuropsiquiatr2010，68，5： | 1 |
| 17 | The role of community involvement and number/type of visitors on tourism impacts : A controlled comparison of Annapurna, Nepal and Northwest Yunnan, China 显示文摘 | Gyan P N Morais D B Dowler L | 2006 | Tourism Management2006，27，6： | 1 |
| 18 | Strawberry-tree, blackthorn and rose fruits: Detailed characterization, in nutrients and phytochemicals with antioxidant properties显示文摘 | BARROS L CARVALHO A M MORAIS J S | 2010 | Food Chemistry2010，120，1： | 1 |
| 19 | Gastroprotective effect of the ethanolic extract and fractions obtained from Syngonanthus bisulcatus Rul显示文摘 | Batista LM de Almeida ABA de Morais Lima R de Sousa Falc(a)o H Ferreira AL de Pietro Magri L Coelho RG Calvo TR Vilegas W Monteiro Souza Brito AR | | 0，，1： | 1 |
| 20 | Combined effects of chemical dip and/or carrageenan coating and/or contolled atmosphere on quality of fresh-cut banana显示文摘 | BICO S L S RAPOSO M F J MORAIS R M S C | 2009 | Food Control2009，20，： | 1 |
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