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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | Mathematical simulation of radial heat transfer in packed beds by pseudohomogeneous modeling显示文摘Uniform flow regime and constant effective thermal conductivity inside packed beds are commonly accepted in the evaluation of the fluid dynamics and heat transfer in such systems.However,several authors have confirmed the presence of an oscillatory velocity profile caused by the effective contribution of porosity profile in the fluid dynamic behavior of packed beds,which directly influences the heat transfer inside the beds.This paper describes the application of a pseudo-homogeneous mathematical model for describing heat transfer in packed beds with oscillatory profiles of velocity and porosity,using a radius-dependent model for effective thermal conductivity k r.Several temperature profiles were obtained in a packed bed system with thermal source located on the wall.The simulated temperature and effective thermal conductivity obtained from simulations were compared with experimental data and calculation from a model based on uniform k r fitting.The results indicate that the proposed mathematical modeling was capable of better representing the heat transfer in the packed bed. | Rodrigo Béttega Marcos Flávio Pinto Moreira Ronaldo Guimaraes Corrêa José Teixeira Freire | 2011 | Particuology2011，9，2： | 2 |
| 4 | Partial characterization of the acidic and basic polypeptides of glycinin 显示文摘 | Moreira M A Hermodson M A Larkins B A | 1979 | Journal of Biological Chemistry1979，254，： | 1 |
| 5 | SuperheatedSteam impingement drying of tortilla chips显示文摘 | Li Y B Seyed-Yagoobi J Moreira R G | 1999 | DryingTechnology An International Journal1999，，17： | 1 |
| 6 | Themml characterization of an epoxy- I)ast underfill material for flip chip packaging 显示文摘 | He Y Moreira B E Overson A el al | 2000 | llmnnochinfiea Aeta2000，3573，14： | 1 |
| 7 | “What is a good digital library?” – A quality model for digital libraries显示文摘 | Marcos André Gon?alves Bárbara L. Moreira Edward A. Fox Layne T. Watson | 2006 | Information Processing and Management2006，，5： | 1 |
| 8 | Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission fusion proteins显示文摘 | Wang X Su B Siedlak SL Moreira PI Fujioka H Wang Y | 2009 | Proc Natl Acad Sci USA2009，105，19： | 1 |
| 9 | Partial characterization of the acidic and basic polypeptides of glycinin显示文摘 | Moreira M A Hermodson M A Larkins B A | 1979 | Journal of Biochemistry1979，254，： | 1 |
| 10 | Absence of asso- ciation between depression and hypertension : results of a prospec- tively designed population - based study 显示文摘 | WIEHE M FUCHS S C MOREIRA L B | 2006 | J Hum Hypertens2006，30，6： | 1 |
| 11 | Soft-tissue profile growth in patients with repaired complete unilateral cleft lip and palate:A cephalometric comparison with normal controls at ages 7,11,and 18 years显示文摘 | Moreira I Suri S Ross B | 2014 | Am J Orthod Dentofacial Orthop2014，145，3： | 1 |
| 12 | New Processes for the Production of Solar-grade Polycrystalline Silicon:A Review显示文摘 | Braga A F B Moreira S P Zampieri P R | | 0，，： | 1 |
| 13 | Gene expression profile of mesenchymal stem cells from paired umbilical cord units:cord is different from blood stem cell显示文摘 | SECCO M MOREIRA Y B ZUCCONI E | 2009 | Stem Cell Rev2009，5，4： | 1 |
| 14 | Adsorptive striooing voltammetric behavior of UO2(II) complexed with the Schiff base N, N-prime-ethylenebis in 4-( 2-hydrox- ygthyl)-1-piperazine ethanesulfonic acid medium显示文摘 | Bastod M B R Moreira J C Farias P A M | 2000 | Anal Chim Acta2000，408，1： | 1 |
| 15 | New processes for the production of solar-grade polycrystalline silicon: A review显示文摘 | Braga A F B Moreira S P Zampieri P R | 2008 | Solar Energy Materials and Solar Cells2008，92，4： | 1 |
| 16 | Life cycle inventory of medium density fiberboard显示文摘 | Rivela B Moreira M T Feijoo G | 2007 | The International Journal of Life Cycle Assessment2007，12，3： | 1 |
| 17 | Direct determination of paracetamol in powdered pharmaceutical samples by fluorescence spectroscopy显示文摘 | Moreira Altair B Tescarollo I L Neto G O | 2005 | Analytica Chimica Acta2005，539，1： | 1 |
| 18 | Study of the aroma compounds of rose apple (Syzygium jambos Alston) fruit from Brazil显示文摘 | Guedes C M Pinto A B Moreira R F A | 2004 | Eur Food Res Technol2004，219，： | 1 |
| 19 | A freeze -explosion technique for Increasing cellulose hydrolysis显示文摘 | Dale B E Moreira M J | 1982 | Biotechnol Bioeng Symp1982，，12： | 1 |
| 20 | Adsorptive stripping voltammetric behaviour of UO2 (Ⅱ) complexed with the Schiff base N , N - prime - ethylenebis (salicylidenimine) in aqueous 4 - (2 - hydroxyethy) - 1 - piperazme ethanesulfonic acid medium 显示文摘 | Bastos M B R Moreira J C Farias P A M | 2000 | Analytica Chimica Acta2000，408，： | 1 |
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