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| 1 | 利用RNA干扰技术抑制水稻淀粉极限糊精酶基因表达显示文摘构建了含极限糊精酶基因片段反向重复结构的RNAi载体,抑制水稻籽粒中极限糊精酶基因表达获得了极限糊精酶基因功能缺失突变体。经酶切及序列测定证实,成功地构建了胚乳特异表达启动子启动的水稻极限糊精酶基因反向重复结构RNAi载体;通过根癌农杆菌(Agrobacterium tumefaciens)介导水稻(Oryza sativa sp.japonica)转化,经PCR及Southern杂交检测,获得28个水稻转基因再生株系;以极限糊精酶抗体对转基因株系胚乳发育期籽粒蛋白质进行Western杂交,并经SDS-PAGE极限糊精酶活性检测,结果显示,该反向重复结构在胚乳发育期表达,减少了极限糊精酶的积累,获得了不同沉默效果的转基因株系。转化株系012的极限糊精酶活性只有野生型的10%,表明该载体可有效地抑制水稻胚乳中极限糊精酶的活性。 | 黄冰艳 李忠谊 吉万全 海燕 Fleming J Morell M Rahman S | 2007 | 农业生物技术学报2007，15，1： | 13 |
| 2 | Sternoclavicular joint dislocation and its management: A review of the literature显示文摘Dislocations of the sternoclavicular joint(SCJ) occur with relative infrequency and can be classified into anterior and posterior dislocation, with the former being more common. The SCJ is inherently unstable due to its lack of articular contact and therefore relies on stability from surrounding ligamentous structures, such as the costoclavicular, interclavicular and capsular ligaments. The posterior capsule has been shown in several studies to be the most important structure in determining stability irrespective of the direction of injury. Posterior dislocation of the SCJ can be associated with life threatening complications such as neurovascular, tracheal and oesophageal injuries. Due to the high mortality associated with such complications, these injuries need to be recognised acutely and managed promptly. Investigations such as x-ray imaging are poor at delineating anatomy at the level of the mediastinum and therefore CT imaging has become the investigation of choice. Due to its rarity, the current guidance on how to manage acute and chronic dislocations is debatable. This analysis of historical and recent literature aims to determine guidance on current thinking regarding SCJ instability, including the use of the Stanmore triangle. The described methods of reduction for both anterior and posterior dislocations and the various surgical reconstructive techniques are also discussed. | Daniel J Morell David S Thyagarajan | 2016 | World Journal of Orthopedics2016，7，4： | 10 |
| 3 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 4 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 5 | Lipid peroxidation products and antioxidants in human disease显示文摘 | Romero F J Morell F B Romero M J | 1998 | Environ Health Perspect1998，106，： | 1 |
| 6 | A review of image denoising algorithms with a new one显示文摘 | Buades A Coll B Morel J M | 2005 | Multiscale Modeling and Simulation:A SIAM Interdisciplinary Journal2005，4，2： | 1 |
| 7 | A review of image denoising algorithms, with a new one 显示文摘 | BUADES A COLL B MOREL J M | 2005 | Multiscale Modeling and Simulation2005，4，2： | 1 |
| 8 | Iodine intoxication after subcutaneous irrigations of povidone-iodine显示文摘 | Labbe G Mahul P Morel J | 2003 | Ann Fr Anesth Reanim2003，22，1： | 1 |
| 9 | ASIFT A new framework for fully affine invariant image comparison显示文摘 | MOREL J M YU G | 2009 | SI- AM Journal on Imaging Sciences2009，2，2： | 1 |
| 10 | A review of image denoising algorithms,with a new one显示文摘 | Buades A Coll B Morel J M | 2005 | Multiscale Model Simul2005，4，2： | 1 |
| 11 | Influence of sludge-amendant or nutrient addition on the biodegradation of the herbicide isoproturon in soil显示文摘 | Perrin-Ganier C Schiavon F Morel J L Schiavon M | 2001 | Chemosphere2001，44，： | 1 |
| 12 | ASIFT:A New Framework for Fully Affine Invariant Image Comparison显示文摘 | Morel J M Yu G | 2009 | SIAM Journal on Imaging Sciences2009，2，2： | 1 |
| 13 | A review of image denoising algorithms,with a new one显示文摘 | Buades A Coll B Morel J | 2005 | Multiscale Modeling and Simulation2005，4，2： | 1 |
| 14 | Image selective smoothing and edge detection by nonlinear diffusion 显示文摘 | Catte F Lions P L Morel J M | 1992 | SIAM Journal on Nu- merical Analysis1992，29，1： | 1 |
| 15 | A non-local algorithm for im- age denoising显示文摘 | Buades A Colt B Morel J M | 2005 | IEEE Computer Vision and Pattern Rec- ognition2005，2，： | 1 |
| 16 | Neighborhood Filters and PDE's显示文摘 | Buades A Coll B Morel J M | 2006 | Numerische Mathematik2006，105，1： | 1 |
| 17 | Nonlocal image and movie denoising 显示文摘 | BUADES A COLL B MOREL J M | 2007 | International Journal of Computer Vision2007，76，2： | 1 |
| 18 | Image selective smoothing and edge detection by nonlinear diffusion显示文摘 | Carte F Lions P L Morel J M | 1992 | SIAM J Numerical Analysis1992，29，1： | 1 |
| 19 | Dual morphology and topography of the corticothalamic terminals originating from the primary,supplementary motor,and dorsal premotor cortical areas in macaque monkeys 显示文摘 | Rouiller EM Tanne J Morel V | 1998 | J Comp Neurol1998，396，： | 1 |
| 20 | Image selective smoothing and edge detection by nonlinear diffusion II 显示文摘 | ALVAREZ L LIONS P L MOREL J M | 1992 | SIAM Journal of Numerical Analysis1992，29，3： | 1 |
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