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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 3 | Elevated MMP - 12 protein levels in induced sputum from patients with COPD 显示文摘 | Demedts I K Morel - Montero A Lebecque S Pacheco Y Cataldo D Joos G F Pauwels R A Brusselle G G | 2006 | Thorax2006，61，6： | 1 |
| 4 | Impact of LDL carotenoid and α-tocopherol content on LDL oxidation by endothelial cells in culture显示文摘 | Dugas T R Morel D W Harrison E H | 1998 | J Lipid Res1998，39，5： | 1 |
| 5 | The biogeochemical cycling of elemental mercury-anthropogenic influences 显示文摘 | Mason R P Fitzgerald W F Morel F M M | 1994 | Geochimica et Cosmochimica Acta1994，58，15： | 1 |
| 6 | The organization of genes tightly linked to the Ha locus in Aegilops tauschii the Dgenome donor to wheat显示文摘 | Turnbull K.M Turner M Mukai Y Yamamoto M Morell M.K Appels R and Rahman S | | 0，，02： | 1 |
| 7 | Low densitylipoprotein cytotoxicity induced by free radical perox-idation of lipid显示文摘 | Morel D W Hessler J R Chisolm G M | 1983 | J Lipid Res1983，24，： | 1 |
| 8 | Comparison of right ventricular systolic function in patients with low risk and intermediate-to-high risk pulmonary embolism:a two-dimensional strain imaging study显示文摘 | Descotes-Genon V Chopard R Morel M | 2013 | Echocardiography2013，30，3： | 1 |
| 9 | Urban soil management:a growing concern显示文摘 | MOREL J-L | 2001 | SoilSci2001，65，1： | 1 |
| 10 | Dietary supplementation with β-carotene, but not with lycopene,inhibits endothelial cell-mediated oxidation of low-density lipoprotein显示文摘 | Dugas T R Morel D W Harrison E H | 1999 | Free Radic Biol Med1999，26，910： | 1 |
| 11 | LSD:A fast line segment detector with a false detection control显示文摘 | Gioi R G V Jakubowicz J Morel J M Randall G | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，4： | 1 |
| 12 | Urban soil management a growing concern显示文摘 | De Kmpe C R Morel J L | 2001 | Soil Science2001，165，： | 1 |
| 13 | Circadian clock regulation of starch metabolism establishes GBSSI as a major contributor to amylopectin synthesis in Chlamydomonas reinhardtii 显示文摘 | Ral J Colleoni C Wattebted F Dauville D Nempont C Deschamps P Li Z Morell M Chibbar R Purton S | 2006 | Plant Physiology2006，142，1： | 1 |
| 14 | LSD: A fast line segment detector with a false detection control显示文摘 | von Gioi R G Jakubowicz J Morel J M | 2001 | IEEE Transactions on Pattern Analysis and Machine Intelligence2001，32，4： | 1 |
| 15 | Role of sp2 C Cluster Size on the Field Emission Properties of Sulfur-incorporated Nanocomposite Carbon Thin Films显示文摘 | Gupta S Weiner B R Morell G | 2002 | Appl Phys Lett2002，80，： | 1 |
| 16 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
| 17 | Combustion synthesis, sintering and magnetical properties of nanocristalline Ni-Zn ferrites doped with sa- marium 显示文摘 | Ana Cristina Fm Costa Marcio R Morell Ruth Hga Kim- inami | 2004 | Journal of materials science2004，39，： | 1 |
| 18 | Urban soil management: A growing concern显示文摘 | De Kimpe C R Morel J L | 2000 | Soil Science2000，165，： | 1 |
| 19 | A Model for Predicting Spatially and Time Resolved Convective Heat Transfer in Bowl-in-piston Combustion Chambers显示文摘 | MOREL T KERIBAR R | | SAE0，，： | 1 |
| 20 | soil management: agrow- hag concern 显示文摘 | Kimpe D C R Morel J L Urban | 2000 | Soil Science2000，165，1： | 1 |
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